Extraction of antioxidant compounds from blackberry (Rubus sp.) bagasse using supercritical CO2 assisted by ultrasound

2014 ◽  
Vol 94 ◽  
pp. 223-233 ◽  
Author(s):  
José Luis Pasquel Reátegui ◽  
Ana Paula da Fonseca Machado ◽  
Gerardo F. Barbero ◽  
Camila A. Rezende ◽  
Julian Martínez
Keyword(s):  
Supercritical Co2 ◽  
Antioxidant Compounds

scholarly journals Supercritical Antisolvent Fractionation of Antioxidant Compounds from Salvia officinalis

2021 ◽  
Vol 22 (17) ◽  
pp. 9351
Author(s):  
Raquel Mur ◽  
Juan I. Pardo ◽  
M. Rosa Pino-Otín ◽  
José S. Urieta ◽  
Ana M. Mainar
Keyword(s):  
Antioxidant Activity ◽  
Rosmarinic Acid ◽  
Supercritical Co2 ◽  
Qsar Model ◽  
Salvia Officinalis ◽  
Training Dataset ◽  
Antioxidant Compounds ◽  
Supercritical Antisolvent ◽  
Pure Compounds ◽  
Co2 Flow

The increasing interest towards greener antioxidants obtained via natural sources and more sustainable processes encourages the development of new theoretical and experimental methods in the field of those compounds. Two advanced separation methods using supercritical CO2 are applied to obtain valuable antioxidants from Salvia officinalis, and a first approximation to a QSAR model relating molecular structure with antioxidant activity is explored in order to be used, in the future, as a guide for the preselection of compounds of interest in these processes. Separation experiments through antisolvent fractionation with supercritical CO2 were designed using a Response Surface Methodology to study the effect of pressure and CO2 flow rate on both mass yields and capability to obtain fractions enriched in three antioxidant compounds: chlorogenic acid, caffeic acid and rosmarinic acid which were tracked using HPLC PDA. Rosmarinic acid was completely retained in the precipitation vessel while chlorogenic and caffeic acids, though distributed between the two separated fractions, had a major presence in the precipitation vessel too. The conditions predicted for an optimal overall yield and enrichment were 148 bar and 10 g/min. Although a training dataset including much more compounds than those now considered can be recommended, descriptors calculated from the σ-profiles provided by COSMO-RS model seem to be adequate for estimating the antioxidant activity of pure compounds through QSAR.

scholarly journals Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 96
Author(s):  
Raquel Mur ◽  
Elisa Langa ◽  
M. Rosa Pino-Otín ◽  
José S. Urieta ◽  
Ana M. Mainar
Keyword(s):  
Supercritical Co2 ◽  
Computational Study ◽  
Skin Permeability ◽  
Antioxidant Compounds ◽  
Calendula Officinalis ◽  
Permeability Model ◽  
Cosmetic Industry ◽  
Stratum Spinosum ◽  
Co2 Flow ◽  
Supercritical Technologies

The growing interest in the cosmetic industry in using compounds of natural and sustainable origin that are safe for humans is encouraging the development of processes that can satisfy these needs. Chlorogenic acid (CHA), caffeic acid (CAF) and ferulic acid (FA) are three compounds widely used within the cosmetic industry due to their functionalities as antioxidants, collagen modifiers or even as radiation protectors. In this work, two advanced separation techniques with supercritical CO2 are used to obtain these three compounds from Calendula officinalis, and these are then evaluated using a computational skin permeability model. This model is encompassed by the COSMO-RS model, the calculations of which make it possible to study the behaviour of the compounds in the epidermis. The results show that both CAF and FA are retained in the stratum corneum, while CHA manages to penetrate to the stratum spinosum. These compounds were concentrated by antisolvent fractionation with super-critical CO2 using a Response Surface Methodology to study the effect of pressure and CO2 flow rate. CHA, CAF and FA were completely retained in the precipitation vessel, with concentrations between 40% and 70% greater than in the original extract. The conditions predicted that the optimal overall yield and enrichment achieved would be 153 bar and 42 g/min.

Antioxidant compounds extracted from Diaporthe schini using supercritical CO2 plus cosolvent

2019 ◽  
Vol 43 (1) ◽  
pp. 133-141 ◽  
Author(s):  
Barbara Vargas da Rosa ◽  
Kátia Regina Kuhn ◽  
Gustavo Andrade Ugalde ◽  
Giovani Leone Zabot ◽  
Raquel Cristine Kuhn
Keyword(s):  
Supercritical Co2 ◽  
Antioxidant Compounds

Supercritical CO2 to recover extracts enriched in antioxidant compounds from beetroot aerial parts

2019 ◽  
Vol 19 ◽  
pp. 101169 ◽  
Author(s):  
Heloísa Fabian Battistella Lasta ◽  
Lucas Lentz ◽  
Natália Mezzomo ◽  
Sandra Regina Salvador Ferreira
Keyword(s):  
Supercritical Co2 ◽  
Antioxidant Compounds ◽  
Aerial Parts

Anti-diabetic properties of non-polar Toona sinensis Roem extract prepared by supercritical-CO2 fluid

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
YH Tsai ◽  
TJ Hsieh ◽  
MC Liao ◽  
PJ Lien ◽  
CC Sun ◽  
...  
Keyword(s):  
Supercritical Co2 ◽  
Toona Sinensis ◽  
Supercritical Co2 Fluid

Effect of climatic conditions and soil type on antioxidant compounds in organic and conventional blueberries (Vaccinium corymbosum L.)

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
MD López ◽  
P Jara ◽  
S Fischer ◽  
R Wilckens ◽  
H Serri ◽  
...  
Keyword(s):  
Soil Type ◽  
Vaccinium Corymbosum ◽  
Climatic Conditions ◽  
Antioxidant Compounds

Study of the radiomodifier effect of Pityrocarpa moniliformis extract

2019 ◽  
Vol 7 (2A) ◽  
Author(s):  
João Victor Torres de Moraes ◽  
Ricardo Luiz Calazans Luna Filho ◽  
Williams Nascimento de Siqueira ◽  
Hianna Arely Milca Fagundes Silva ◽  
Dewson Rocha Pereira ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cellular Response ◽  
Biomphalaria Glabrata ◽  
Toxicity Tests ◽  
Antioxidant Compounds ◽  
Blastula Stage ◽  
Natural Substances ◽  
60Co Source ◽  
60Co Gamma ◽  
60Co Gamma Radiation

Ionizing radiation has been applied in several areas of knowledge, among them the study of the radiomodifier activity of natural substances. These substances can modify the cellular response to the damage induced by the radiation. Therefore, this work aimed to evaluate the radiomodifier action of Pityrocarpa moniliformis extract on Biomphalaria glabrata embryos exposed to 60Co gamma radiation. Initially, toxicity tests were performed on the extract against the B. glabrata embryos for the choice of concentration that did not cause death and embryonic malformation. Then, the antioxidant activity of the P. moniliformis extract with flavonoids and phenolic compounds was evaluated by means of the ABTS method. To evaluate the radiomodifier activity of the extract, embryos were selected in the blastula stage and irradiated with 7.5 Gy in a 60Co source (gammacell-Co60). Then, the embryos were exposed for 24 h to the extract of P. moniliformis at a concentration of 250 μg/mL. The results showed that the extract of P. moniliformis presents flavonoids and enzymatic inhibition by ABTS, which demonstrates the presence of antioxidant compounds. However, the tests of the radiomodifier activity did not present radioprotective effect for embryos exposed to ionizing radiation.

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