Melting point depression of Piroxicam in carbon dioxide+co-solvent mixtures and inclusion complex formation with β-cyclodextrin

2012 ◽  
Vol 71 ◽  
pp. 19-25 ◽  
Author(s):  
Heather E. Grandelli ◽  
John C. Hassler ◽  
Abby Whittington ◽  
Erdogan Kiran
Keyword(s):  
Carbon Dioxide ◽  
Melting Point ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Melting Point Depression ◽  
Solvent Mixtures ◽  
Inclusion Complex Formation

Effect of starch-lipids inclusion complex formation on functional properties of flour in tandoori roti

2000 ◽  
Vol 69 (2) ◽  
pp. 129-133 ◽  
Author(s):  
Narpinder Singh ◽  
Kulwinder Kaur ◽  
Hardeep Singh ◽  
Harmeet Singh
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Functional Properties ◽  
Inclusion Complex Formation

Inclusion Complex Formation of 1,8-Dihydroxyanthraquinone with Cyclodextrins in Aqueous Solution and in Solid State

1988 ◽  
Vol 77 (6) ◽  
pp. 523-526 ◽  
Author(s):  
Giulietta Smulevich ◽  
Alessandro Feis ◽  
Giovanni Mazzi ◽  
Franco F. Vincieri
Keyword(s):  
Aqueous Solution ◽  
Solid State ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complex Formation

Alkalinizing Water-Soluble Local Anesthetic Solutions by Addition of Cyclodextrin

1998 ◽  
Vol 23 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Michio Miyoshi ◽  
Toshiaki Imoto ◽  
Yasutake Hiji
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Water Soluble ◽  
Spectral Change ◽  
Practical Application ◽  
Inclusion Complex Formation ◽  
Physiologic Saline ◽  
Form Inclusion Complex

Background and objectivesThe use of sodium bicarbonate for alkalinization of local anesthetics to improve their efficacy has some disadvantages including decreased stability of the solutions. The present study was performed to evaluate usefulness of cyclodextrins (CDs) in improving the solubility and stability of local anesthetic solutions at near physiologic pH without precipitation.MethodsSolubility of local anesthetics with or without CDs in physiologic saline was investigated by monitoring cloudiness or precipitate formation visually and by recording absorbance at 620 nm. Interaction of anesthetic and CD was also studied spectrophotometrically using spectral change of the drugs associated with the inclusion complex formation.ResultsCyclodextrins improved the solubility and stability of the four local anesthetics studied (dibucaine, tetracaine, bupivacaine, and lidocaine). In the neutral pH region, the effects of the CDs were more significant with dibucaine and tetracaine, which are more hydrophobic than the other two. A type of effective CD was different for each anesthetic depending partly on the tendency to form inclusion complex with local anesthetic. The local anesthetic solutions solubilized by CDs were found to remain clear for more than 72 hours without any visible precipitation or turbidity at neutral pHs.ConclusionsThe improved solubility of local anesthetics by adding CD may be caused by inclusion complex formation of CD with local anesthetics. This new preparation for the alkalinized water-soluble anesthetic solutions may be useful for practical application in the clinical setting, although this awaits further study.

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