Separation of enantiomers by diastereomeric salt formation and precipitation in supercritical carbon dioxide

2007 ◽  
Vol 40 (1) ◽  
pp. 67-73 ◽  
Author(s):  
A. Martín ◽  
M.J. Cocero
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Salt Formation ◽  
Separation Of Enantiomers ◽  
Supercritical Carbon

scholarly journals Resolution of ibuprofen with primary amine carbamates in supercritical carbon dioxide

2019 ◽  
Vol 63 (2) ◽  
pp. 312-317
Author(s):  
László Lőrincz ◽  
Zsolt Hovonyecz ◽  
János Madarász ◽  
Erzsébet Varga ◽  
Edit Székely
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Crystalline Phase ◽  
Primary Amine ◽  
Salt Formation ◽  
Formation Reaction ◽  
Resolving Agents ◽  
Short Times ◽  
Supercritical Carbon

Three new, successful resolving agents, namely (S)-2-phenylglycinol, (R)-1-phenylethanaminium (R)-(1-phenylethyl) carbamate and (S)-2-hydroxy-1-phenylethanaminium (S)-(2-hydroxy-1-phenylethyl) carbamate of ibuprofen are presented. The carbamate salts are stable white crystals, they can be easily stored and handled. All salt forming resolution were performed in supercritical carbon dioxide as the only solvent. The enantioseparations were efficient (approx. 50 % enantiomeric purities, > 90 % yields in the crystalline phase) and robust. Unlike previous experiences with primary amine resolving agents, the diastereomeric salt formations and resolutions were competed in short times, even within one hour suggesting that the carbamates are intermediates of the salt formation reaction.

Diastereomer salt formation of ibuprofen in supercritical carbon dioxide

2012 ◽  
Vol 69 ◽  
pp. 113-116 ◽  
Author(s):  
György Bánsághi ◽  
Edit Székely ◽  
David Méndez Sevillano ◽  
Zoltán Juvancz ◽  
Béla Simándi
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Salt Formation ◽  
Supercritical Carbon
Sign in / Sign up

Export Citation Format

Share Document