Nanoparticle formation in rapid expansion of water-in-supercritical carbon dioxide microemulsion into liquid solution

2005 ◽  
Vol 34 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Mohammed J. Meziani ◽  
Pankaj Pathak ◽  
Frank Beacham ◽  
Lawrence F. Allard ◽  
Ya-Ping Sun
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Liquid Solution ◽  
Rapid Expansion ◽  
Nanoparticle Formation ◽  
Supercritical Carbon

scholarly journals Micronization of Cetirizine Using Rapid Expansion of Supercritical Carbon Dioxide

OALib ◽  
2015 ◽  
Vol 02 (04) ◽  
pp. 1-14 ◽  
Author(s):  
Ali Zeinolabedini Hezave ◽  
Mostafa Lashkarbolooki ◽  
Feridun Esmaeilzadeh
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Rapid Expansion ◽  
Supercritical Carbon

Preparation of Semi-Conducting Polymeric Nanoparticles by Supercritical Carbon Dioxide RESOLV Process

2008 ◽  
Vol 8 (9) ◽  
pp. 4707-4710 ◽  
Author(s):  
Hullathy Subban Ganapathy ◽  
Jun Ho Kim ◽  
Seung-Soo Hong ◽  
Kwon Taek Lim
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Polymeric Nanoparticles ◽  
High Surface ◽  
Sodium Dodecyl ◽  
Rapid Expansion ◽  
Environmentally Benign ◽  
Spherical Nanoparticles ◽  
Average Size ◽  
Supercritical Carbon

The rapid expansion of supercritical carbon dioxide solutions into a liquid solvent (RESOLV) technique with environmentally benign supercritical carbon dioxide was used to produce semi-conducting polymeric nanoparticles of fluoroalkyl ester substituted thiophenes. When the supercritical solutions of the conjugated polymer, poly[2-(3-thienyl) acetyl-3,3,4,4,5,5,6,6,7,7,8,8,8, tridecafluoro-1-octanate] (PSFTE) were expanded into aqueous solutions through a small capillarynozzle (150 μm), spherical nanoparticles in the range of 50–100 nm were obtained. However, after 15 min of expansion, the particles tended to aggregate to form larger objects due to the high surface energy of the polymeric nanoparticles. In order to prevent the agglomeration of particles, a relatively low concentration of sodium dodecyl sulphate (SDS) or NaCl was used as a stabilizing agent in aqueous solution. While NaCl did not give enough stabilization to the system, uniform spherical nanoparticles of PSFTE having an average size of 45 nm were successfully obtained by SDS stabilization.

scholarly journals Microencapsulation and Nanoencapsulation Using Supercritical Fluid (SCF) Techniques

Pharmaceutics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 21 ◽  
Author(s):  
Soon Hong Soh ◽  
Lai Yeng Lee
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Fluid ◽  
Supercritical Co2 ◽  
Drug Loading ◽  
Particle Morphology ◽  
Operating Conditions ◽  
Rapid Expansion ◽  
Comprehensive Overview ◽  
Supercritical Carbon

The unique properties of supercritical fluids, in particular supercritical carbon dioxide (CO2), provide numerous opportunities for the development of processes for pharmaceutical applications. One of the potential applications for pharmaceuticals includes microencapsulation and nanoencapsulation for drug delivery purposes. Supercritical CO2 processes allow the design and control of particle size, as well as drug loading by utilizing the tunable properties of supercritical CO2 at different operating conditions (flow ratio, temperature, pressures, etc.). This review aims to provide a comprehensive overview of the processes and techniques using supercritical fluid processing based on the supercritical properties, the role of supercritical carbon dioxide during the process, and the mechanism of formulation production for each process discussed. The considerations for equipment configurations to achieve the various processes described and the mechanisms behind the representative processes such as RESS (rapid expansion of supercritical solutions), SAS (supercritical antisolvent), SFEE (supercritical fluid extraction of emulsions), PGSS (particles from gas-saturated solutions), drying, and polymer foaming will be explained via schematic representation. More recent developments such as fluidized bed coating using supercritical CO2 as the fluidizing and drying medium, the supercritical CO2 spray drying of aqueous solutions, as well as the production of microporous drug releasing devices via foaming, will be highlighted in this review. Development and strategies to control and optimize the particle morphology, drug loading, and yield from the major processes will also be discussed.

l-Menthol crystal micronized by rapid expansion of supercritical carbon dioxide

2012 ◽  
Vol 18 (3) ◽  
pp. 904-908 ◽  
Author(s):  
Nara Suankaew ◽  
Yukihiko Matsumura ◽  
Isara Saramala ◽  
Uracha R. Ruktanonchai ◽  
Apinan Soottitantawat ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Rapid Expansion ◽  
Supercritical Carbon
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