scholarly journals Structural Mechanisms Underlying Activity Changes in an AMPA-type Glutamate Receptor Induced by Substitutions in Its Ligand-Binding Domain

Structure ◽  
2019 ◽  
Vol 27 (11) ◽  
pp. 1698-1709.e5
Author(s):  
Masayoshi Sakakura ◽  
Yumi Ohkubo ◽  
Hiraku Oshima ◽  
Suyong Re ◽  
Masahiro Ito ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Structural Mechanisms

scholarly journals Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface

Neuron ◽  
2012 ◽  
Vol 76 (3) ◽  
pp. 565-578 ◽  
Author(s):  
Julien Veran ◽  
Janesh Kumar ◽  
Paulo S. Pinheiro ◽  
Axel Athané ◽  
Mark L. Mayer ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Function ◽  
Dimer Interface

scholarly journals D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2

Structure ◽  
2020 ◽  
Vol 28 (10) ◽  
pp. 1168-1178.e2
Author(s):  
Alfred C. Chin ◽  
Remy A. Yovanno ◽  
Tyler J. Wied ◽  
Ariel Gershman ◽  
Albert Y. Lau
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Ionotropic Glutamate Receptor

Structure and mechanism of the oestrogen receptor

2003 ◽  
Vol 31 (1) ◽  
pp. 56-59 ◽  
Author(s):  
E.H. Kong ◽  
A.C.W. Pike ◽  
R.E. Hubbard
Keyword(s):  
Ligand Binding ◽  
Transcriptional Activation ◽  
Oestrogen Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Pharmacological Properties ◽  
Receptor Ligand ◽  
Structural Mechanisms

We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.

scholarly journals Agonist-induced Isomerization in a Glutamate Receptor Ligand-binding Domain

2000 ◽  
Vol 275 (28) ◽  
pp. 21355-21363 ◽  
Author(s):  
Rupert Abele ◽  
Kari Keinänen ◽  
Dean R. Madden
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Ligand
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