scholarly journals Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor

Structure ◽  
2019 ◽  
Vol 27 (4) ◽  
pp. 703-712.e3 ◽  
Author(s):  
Sangbae Lee ◽  
Anita K. Nivedha ◽  
Christopher G. Tate ◽  
Nagarajan Vaidehi
Keyword(s):  
G Protein ◽  
Adenosine A2a Receptor ◽  
Active State ◽  
A2a Receptor ◽  
Adenosine A2a

The Controversial Role of Adenosine A2A Receptor Antagonists as Neuro-protective Agents

2004 ◽  
Vol 4 (1) ◽  
pp. 35-45 ◽  
Author(s):  
Patrizia Popoli ◽  
David Blum ◽  
Annita Pintor ◽  
Maria Tebano ◽  
Claudio Frank ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Antagonists ◽  
Protective Agents ◽  
Adenosine A2a Receptor Antagonists ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals The Role of Adenosine A2A Receptor Signaling in Bronchiolitis Obliterans

2009 ◽  
Vol 88 (4) ◽  
pp. 1071-1078 ◽  
Author(s):  
Christine L. Lau ◽  
Yunge Zhao ◽  
Irving L. Kron ◽  
Mark H. Stoler ◽  
Victor E. Laubach ◽  
...  
Keyword(s):  
Bronchiolitis Obliterans ◽  
Adenosine A2a Receptor ◽  
Receptor Signaling ◽  
A2a Receptor ◽  
Adenosine A2a

Role of adenosine A2A receptor signaling in the nicotine-evoked attenuation of reflex cardiac sympathetic control

2011 ◽  
Vol 254 (3) ◽  
pp. 229-237 ◽  
Author(s):  
Mahmoud M. El-Mas ◽  
Sahar M. El-gowilly ◽  
Mohamed A. Fouda ◽  
Evan I. Saad
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Signaling ◽  
Sympathetic Control ◽  
A2a Receptor ◽  
Adenosine A2a

Parkinsonism-like disease induced by rotenone in rats: Treatment role of curcumin, dopamine agonist and adenosine A2A receptor antagonist

2021 ◽  
Vol 14 ◽  
Author(s):  
Asmaa Fathy Aboul Naser ◽  
Wessam Magdi Aziz ◽  
Yomna Rashad Ahmed ◽  
Wagdy Khalil Bassaly Khalil ◽  
Manal Abdel Aziz Hamed
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Inflammatory Mediator ◽  
Adenosine A2a Receptor ◽  
Control Group ◽  
A2a Receptor ◽  
Adenosine A2a

Background: Parkinsonism is a neurodegenerative disorder that affects elderly people worldwide. Methods: Curcumin, adenosine A2AR antagonist (ZM241385) and Sinemet® (L-dopa) were evaluated against Parkinson’s disease (PD) induced by rotenone in rats and comparativelyrelatively compared with our previous study on mice model. Results: Rats injected with rotenone showed severe alterations in adenosine A2A receptor gene expression, oxidative stress markers, inflammatory mediator, energetic indices, apoptotic marker and DNA fragmentation levels as compare with the control group. Treatments with curcumin, ZM241385, and Sinemet® restored all the selected parameters. The brain histopathological features of cerebellum regions confirmed our results. By comparing our results with the previous results on mice, we noticed that mice respond to rotenone toxicity and treatments more than rats regarding to behavioral observation, A2AR gene expression, neurotransmitter levels, inflammatory mediator and apoptotic markers, while rats showed higher response to treatments regarding to oxidative stress and energetic indices. Conclusion: Curcumin succeeded to attenuate the severe effects of Parkinson’s disease in rat model and can be consider as a potential dietary supplement. Adenosine A2AR antagonist has almost the same pattern of improvement as Sinemet® and may be considered as a promising therapy against PD. By comparing the role of animal species in response to PD symptoms and treatments, our previous report on mice explore the response of mice to rotenone toxicity than rats, while rats showed higher response to treatments. Therefore, no animal model can perfectly recapitulate all the pathologies of PD.

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