scholarly journals Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling

Structure ◽  
2018 ◽  
Vol 26 (2) ◽  
pp. 259-269.e5 ◽  
Author(s):  
Kate L. White ◽  
Matthew T. Eddy ◽  
Zhan-Guo Gao ◽  
Gye Won Han ◽  
Tiffany Lian ◽  
...  
Keyword(s):  
Gpcr Signaling ◽  
Structural Connection

STRUCTURAL CONNECTIONS AND INTERCHANGEABILITY OF ASYMMETRIC TYPES OF THEORETICAL DISTRIBUTIONS

2020 ◽  
Vol 6 (8(77)) ◽  
pp. 13-17
Author(s):  
Azimkhan Kurmankozhayev ◽  
Elmira Seilbekovna Yesbergenova
Keyword(s):  
Weibull Distribution ◽  
Empirical Analysis ◽  
Gamma Distribution ◽  
Statistical Data ◽  
Distribution Patterns ◽  
Structural Relationships ◽  
Statistical Regularities ◽  
Structural Connections ◽  
Characteristic Features ◽  
Structural Connection

Presented the results of evaluation of structural connection, identity and interchangeability of main asymmetric types of theoretical distributions most often acceptable for assessing the distributions of various indicators in geology and technology. The method of empirical analysis and statistical inference was used with the involvement of nonparametric facts according to the distribution patterns. The analysis of the empirical results of the application of the lognormal, gamma distribution and the Weibull distribution with the involvement of extensive statistical data from literary and research sources is carried out. The characteristic features and statistical regularities of distributions inherent to them are revealed, estimated statistical conclusions are obtained, according to which structural relationships between the functions of the lognormal, gamma and Weibull distributions are revealed. The identity and authenticity of the development of probabilistic frequencies in their application have been established, the complex geometric "image" of asymmetry inherent to these types of distributions is generalized. Structural relationships and interchangeability of asymmetric types of distributions are recommended to increase the reliability and credibility of the estimated choice of distribution in conditions of uncertainty and insignificance of statistical data when solving problems associated with forecasts, technological and computer developments.

scholarly journals Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex

2021 ◽  
Vol 7 (21) ◽  
pp. eabg5628
Author(s):  
Julien Bous ◽  
Hélène Orcel ◽  
Nicolas Floquet ◽  
Cédric Leyrat ◽  
Joséphine Lai-Kee-Him ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Antidiuretic Hormone ◽  
Arginine Vasopressin ◽  
Molecular Mechanisms ◽  
Particle Analysis ◽  
Resonance Spectroscopy ◽  
Gpcr Signaling ◽  
Signaling Complex ◽  
Cryo Electron Microscopy ◽  
V2 Receptor

The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2 receptor (V2R) and the Gs protein, promoting kidney water reabsorption. Molecular mechanisms underlying activation of this critical G protein–coupled receptor (GPCR) signaling system are still unknown. To fill this gap of knowledge, we report here the cryo–electron microscopy structure of the AVP-V2R-Gs complex. Single-particle analysis revealed the presence of three different states. The two best maps were combined with computational and nuclear magnetic resonance spectroscopy constraints to reconstruct two structures of the ternary complex. These structures differ in AVP and Gs binding modes. They reveal an original receptor-Gs interface in which the Gαs subunit penetrates deep into the active V2R. The structures help to explain how V2R R137H or R137L/C variants can lead to two severe genetic diseases. Our study provides important structural insights into the function of this clinically relevant GPCR signaling complex.

Chronic alcoholism in relation to attempted or effected suicide. A long-term study

1988 ◽  
Vol 3 (3) ◽  
pp. 181-188 ◽  
Author(s):  
O.M. Lesch ◽  
H. Walter ◽  
R. Mader ◽  
M. Musalek ◽  
K. Zeiler
Keyword(s):  
Suicide Attempts ◽  
Depressive Symptomatology ◽  
Chronic Alcoholism ◽  
Chronic Alcoholic ◽  
Chronic Alcohol Abuse ◽  
Drinking Habits ◽  
Psychiatric Illnesses ◽  
Long Term Study ◽  
Structural Connection

SummaryRushing (1968) offers two hypotheses for the possible structural connection between suicidal and chronic alcoholic case groups : the “processual cause theory” is based on the idea that alcoholism leads through its problematic nature to suicide attempts. In the “common cause theory” alcoholism and suicidai acts are due to mutually shared factors, e.g., social isolation and enforced social integration.Data on suicide and suicide attempts were obtained as a separate aspect of a comprehensive follow-up investigation. All patients from one particular region in Austria, who had been admitted to hospital between 1976 and 1978 for treatment of chronic alcoholism took part in this study. Follow-up time was 4 to 7 years. 101 patients died during this period. 356 patients remained under close follow-up investigation. In addition to information about basic drinking habits, we attempted to identify predictive factors regarding the course of alcoholism and investigated familial circumstances, development and interactions.In contradiction with both theories forwarded by Rushing, we were able to isolate a special subgroup of chronic alcoholics attempting or committing suicide. This group is characterized by a depressive symptomatology (endogeneous-depressive syndrome, according to the Viennese Diagnostic Criteria), as well as by the presence of other psychiatrie disturbances underlying chronic alcohol abuse. Family histories also uncovered evidence of psychiatric illnesses. Cases of negative alteration in social status and problematical partnerships could be found in this subgroup. Drinking habits themselves did not differ from non suicide-prone alcoholics.

scholarly journals GPCR Signaling Rides a Wave of Conformational Changes

Cell ◽  
2016 ◽  
Vol 167 (3) ◽  
pp. 602-603 ◽  
Author(s):  
Louis M. Luttrell
Keyword(s):  
Conformational Changes ◽  
Gpcr Signaling

Poster: CLL-156: Novel CCL22 Mutations Drive Chronic Lymphoproliferative Disorder of NK Cells Through Biased GPCR Signaling

2021 ◽  
Vol 21 ◽  
pp. S222
Author(s):  
Shunsuke Kimura ◽  
Constance Baer ◽  
Mitra S Rana ◽  
Andrew Kleist ◽  
David J. Feith ◽  
...  
Keyword(s):  
Nk Cells ◽  
Lymphoproliferative Disorder ◽  
Gpcr Signaling

scholarly journals Imaging of persistent cAMP signaling by internalized G protein-coupled receptors

2010 ◽  
Vol 45 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Davide Calebiro ◽  
Viacheslav O Nikolaev ◽  
Martin J Lohse
Keyword(s):  
G Protein ◽  
Intracellular Signaling ◽  
Current Model ◽  
Living Cells ◽  
G Protein Coupled Receptors ◽  
Membrane Receptors ◽  
Optical Methods ◽  
Camp Signaling ◽  
Gpcr Signaling ◽  
G Protein Coupled

G protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors. They mediate the effects of several endogenous cues and serve as important pharmacological targets. Although many biochemical events involved in GPCR signaling have been characterized in great detail, little is known about their spatiotemporal dynamics in living cells. The recent advent of optical methods based on fluorescent resonance energy transfer allows, for the first time, to directly monitor GPCR signaling in living cells. Utilizing these methods, it has been recently possible to show that the receptors for two protein/peptide hormones, the TSH and the parathyroid hormone, continue signaling to cAMP after their internalization into endosomes. This type of intracellular signaling is persistent and apparently triggers specific cellular outcomes. Here, we review these recent data and explain the optical methods used for such studies. Based on these findings, we propose a revision of the current model of the GPCR–cAMP signaling pathway to accommodate receptor signaling at endosomes.

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