scholarly journals Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila

Structure ◽  
2015 ◽  
Vol 23 (8) ◽  
pp. 1459-1469 ◽  
Author(s):  
Andrew T. Quaile ◽  
Malene L. Urbanus ◽  
Peter J. Stogios ◽  
Boguslaw Nocek ◽  
Tatiana Skarina ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Legionella Pneumophila ◽  
Functional Divergence

scholarly journals Molecular characterization of a virulence-associated epitope on the lipopolysaccharide ofLegionella pneumophilaserogroup 1

1995 ◽  
Vol 115 (1) ◽  
pp. 71-78 ◽  
Author(s):  
J. H. Helbig ◽  
P. C. Lück ◽  
Y. A. Knirel ◽  
W. Witzleb ◽  
U. Zähringer
Keyword(s):  
Monoclonal Antibodies ◽  
Molecular Characterization ◽  
Legionella Pneumophila ◽  
Reactivity Pattern ◽  
Virulence Marker ◽  
Nonulosonic Acid ◽  
Acetyl Group

SummaryFor identification of lipopolysaccharide (LPS)-associated epitopes ofLegionella pneumophilaserogroup 1, LPS of strain Philadelphia 1 was investigated using monoclonal antibodies (MAbs). The O-specific chain of LPS is a homopolymer of 5-acetamidino-7-acetamido-8-O-acetyl-3,5,7,9-tetradeoxy-D-glycero-L-galacto-nonulosonic acid. At least four immunoaccessible epitopes were recognized by different MAbs on the intact LPS. AfterO-deacetylation of LPS, the reactivity of one of the MAbs (MAb 3/1) was lost, indicating thus that the corresponding epitope is associated with the 8-O-acetyl group. Since the reactivity pattern of the MAb 3/1 is identical with those of the MAb 2 which was considered as a virulence marker for serogroup 1, this epitope may be involved in mediating virulence inL. pneumophila. Four MAbs specific to strains of serogroup 1 other than the monoclonal subtype Philadelphia recognized epitopes on theO-deacetylated LPS of strain Philadelphia 1 and, therefore, the virulence-associated epitope blocks recognition of the immunodeterminants that are accessible on the intact LPS of the strains lacking this epitope.

scholarly journals Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells

2010 ◽  
Vol 10 (1) ◽  
pp. 1 ◽  
Author(s):  
Reika Takamatsu ◽  
Hiromitsu Teruya ◽  
Eriko Takeshima ◽  
Chie Ishikawa ◽  
Kunihiro Matsumoto ◽  
...  
Keyword(s):  
T Cells ◽  
Molecular Characterization ◽  
Legionella Pneumophila ◽  
Interleukin 8

scholarly journals Retraction: Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells

2011 ◽  
Vol 11 (1) ◽  
pp. 127
Author(s):  
Reika Takamatsu ◽  
Hiromitsu Teruya ◽  
Eriko Takeshima ◽  
Chie Ishikawa ◽  
Kunihiro Matsumoto ◽  
...  
Keyword(s):  
T Cells ◽  
Molecular Characterization ◽  
Legionella Pneumophila ◽  
Interleukin 8

Molecular characterization of clinical and environmental isolates of Legionella pneumophila in Norway, 2001–2008

2012 ◽  
Vol 45 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Elisabeth Wedege ◽  
Karin Bolstad ◽  
Katrine Borgen ◽  
Elisabeth Fritzsønn ◽  
Dominique A. Caugant
Keyword(s):  
Molecular Characterization ◽  
Legionella Pneumophila ◽  
Environmental Isolates

1446: Molecular Characterization of Cyclooxygenase-2 in a Stimulated Prostate Stroma Cells

2006 ◽  
Vol 175 (4S) ◽  
pp. 467-467
Author(s):  
Victor K. Lin ◽  
Shih-Ya Wang ◽  
Claus G. Roehrbom
Keyword(s):  
Molecular Characterization ◽  
Cyclooxygenase 2 ◽  
Prostate Stroma
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