scholarly journals Quaternary Structure Change as a Mechanism for the Regulation of Thymidine Kinase 1-Like Enzymes

Structure ◽  
2007 ◽  
Vol 15 (12) ◽  
pp. 1555-1566 ◽  
Author(s):  
Dario Segura-Peña ◽  
Joseph Lichter ◽  
Manuela Trani ◽  
Manfred Konrad ◽  
Arnon Lavie ◽  
...  
Keyword(s):  
Thymidine Kinase ◽  
Quaternary Structure ◽  
Structure Change ◽  
Thymidine Kinase 1

High-level expression and purification of human thymidine kinase 1: Quaternary structure, stability, and kinetics

2006 ◽  
Vol 47 (2) ◽  
pp. 506-515 ◽  
Author(s):  
Markus S. Birringer ◽  
Remo Perozzo ◽  
Elvan Kut ◽  
Corinne Stillhart ◽  
Wanda Surber ◽  
...  
Keyword(s):  
Thymidine Kinase ◽  
Quaternary Structure ◽  
Structure Stability ◽  
Expression And Purification ◽  
Thymidine Kinase 1 ◽  
High Level Expression ◽  
High Level

scholarly journals Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer

ESMO Open ◽  
2021 ◽  
Vol 6 (2) ◽  
pp. 100076
Author(s):  
A. Matikas ◽  
K. Wang ◽  
E. Lagoudaki ◽  
B. Acs ◽  
I. Zerdes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Thymidine Kinase ◽  
Early Breast Cancer ◽  
Prognostic Role ◽  
Thymidine Kinase 1 ◽  
Serum Thymidine Kinase 1

Serological thymidine kinase 1 is a prognostic factor in oesophageal, cardial and lung carcinomas

2010 ◽  
Vol 19 (4) ◽  
pp. 313-318 ◽  
Author(s):  
Zhishan Li ◽  
Yinghong Wang ◽  
Jie He ◽  
Jie Ma ◽  
Liang Zhao ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Thymidine Kinase ◽  
Thymidine Kinase 1 ◽  
Lung Carcinomas

Can Serum Thymidine Kinase 1 Detect Small Invisible Malignant Tumours?

2021 ◽  
Author(s):  
Ji Zhou ◽  
Huijun Li ◽  
Cong Fang ◽  
Junye Tan ◽  
Peng Gao ◽  
...  
Keyword(s):  
Thymidine Kinase ◽  
Total Protein ◽  
Magnetic Beads ◽  
Polyclonal Antibodies ◽  
Malignant Tumour ◽  
The Body ◽  
Cell Diameter ◽  
Malignant Tumours ◽  
Thymidine Kinase 1 ◽  
Protein Cell

Abstract Objectives. Early detection of malignant tumour is a prerequisite for a successful treatment. Here we investigate if thymidine kinase 1 is more sensitive than imaging technology to discover small invisible malignant tumours.Material and Methods. The cellular concentration of TK1 was determined by a novel automatic chemiluminescence analyzer of magnetic particle immune sandwich minimum. The primary and secondary antibodies linked to the magnetic beads were chicken anti-human thymidine kinase 1 IgY-polyclonal antibodies (IgY pAb). The minimum number of cells able to be detected by the novel detection technology using an automatic chemiluminescence analyzer were determined based on the cellar TK1 concentration of low and high TK1 cell lines of known cell count.Results. The TK1 concentration of malignant cell was found to be 0.021 pg/cell. Assuming 200 pg of total protein/cell, TK1 corresponds to 0.01 % of the total protein/cell. The concentration of TK1 in human blood serum of malignant patients is in the range of 2-10 pmol/l (pM), corresponding to about 50 x106 growing cells in the body that release TK1 into 5 litre blood. The limit visibility by imaging of a tumour is about 1 mm in diameter, corresponding to about 109cells of a cell diameter of 1µm. Conclusion. TK1 is more sensitive than imaging.

scholarly journals High Serum Thymidine Kinase 1 Level Predicts Poorer Survival in Patients With Chronic Lymphocytic Leukemia

2010 ◽  
Vol 134 (3) ◽  
pp. 472-477 ◽  
Author(s):  
Sergej N. Konoplev ◽  
Herbert A. Fritsche ◽  
Susan O’Brien ◽  
William G. Wierda ◽  
Michael J. Keating ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Thymidine Kinase ◽  
High Serum ◽  
Lymphocytic Leukemia ◽  
Thymidine Kinase 1 ◽  
Serum Thymidine Kinase 1

Usefulness of Serum Thymidine Kinase 1 as a Biomarker for Aggressive Clinical Behavior in B-cell Lymphoma

2016 ◽  
Vol 6 (1) ◽  
pp. 25
Author(s):  
Heyjin Kim ◽  
Hye Jin Kang ◽  
Jin Kyung Lee ◽  
Young Jun Hong ◽  
Seok-Il Hong ◽  
...  
Keyword(s):  
B Cell ◽  
Thymidine Kinase ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Thymidine Kinase 1 ◽  
Clinical Behavior ◽  
Aggressive Clinical Behavior ◽  
Serum Thymidine Kinase 1

scholarly journals Thymidine kinase-1/CD31 double immunostaining for identifying activated tumor vessels

2018 ◽  
Vol 94 (1) ◽  
pp. 60-64 ◽  
Author(s):  
S. Okamura ◽  
T. Osaki ◽  
K. Nishimura ◽  
H. Ohsaki ◽  
M. Shintani ◽  
...  
Keyword(s):  
Thymidine Kinase ◽  
Double Immunostaining ◽  
Thymidine Kinase 1 ◽  
Tumor Vessels
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