scholarly journals GTP-Ras Disrupts the Intramolecular Complex of C1 and RA Domains of Nore1

Structure ◽  
2006 ◽  
Vol 14 (5) ◽  
pp. 881-888 ◽  
Author(s):  
Elena Harjes ◽  
Stefan Harjes ◽  
Sabine Wohlgemuth ◽  
Karl-Heinz Müller ◽  
Elmar Krieger ◽  
...  
Keyword(s):  
Intramolecular Complex

Deboronation of New Clarithromycin-Benzo[c][1,2]oxaborole Conjugates

2019 ◽  
Vol 17 (2) ◽  
pp. 99-104
Author(s):  
Gennady B. Lapa ◽  
Elena B. Isakova ◽  
Elena B. Mirchink ◽  
Maria N. Preobrazhenskaya
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Carbonyl Group ◽  
Nucleophilic Attack ◽  
Bacterial Strains ◽  
Antimicrobial Spectrum ◽  
Intramolecular Complex ◽  
Active Fragments ◽  
Proven Method ◽  
Antibacterial Spectrum

<P>Background: The conjugates of antibiotics are new molecules that might show new antibacterial spectrum and overcome resistance of insusceptible bacterial strains. Modification of known antibiotics like Clarithromycin with active fragments is laborious and proven method to overcome resistance of such strains. Methods: The conjugates of Clarithromycin and Benzo[c][1,2]oxaboroles were synthesized using long linkers to extend antimicrobial spectrum of this antibiotic. Results and Discussion: Unexpected intramolecular deboronation of these bioconjugated was found to occur when the linker contained two or more CH2-groups. Molecular modeling was used to understand the source of instability and show a possibility of intramolecular complex of carbonyl group at C-9 in Clarithromycin core and hydroxy-borole moiety. This could facilitate nucleophilic attack of methanol used in reactions to destroy benzo[c][1,2]oxaboroles fragments and leave stable hydroxyl-aryl molecules. Conclusion: The loss of boron from benzo[c][1,2]oxoborole fragments leads to the significant decrease of antimicrobial activity of synthesized antibiotics.</P>

scholarly journals Crystallization and diffraction of an Isl1–Ldb1 complex

2012 ◽  
Vol 68 (11) ◽  
pp. 1398-1401 ◽  
Author(s):  
Morgan S. Gadd ◽  
David A. Jacques ◽  
J. Mitchell Guss ◽  
Jacqueline M. Matthews
Keyword(s):  
Unit Cell ◽  
Homeodomain Protein ◽  
Unit Cell Parameters ◽  
Space Group ◽  
Cell Parameters ◽  
Lim Domains ◽  
Intramolecular Complex ◽  
Orthorhombic Crystals ◽  
Peptide Region ◽  
Lim Homeodomain

A stable intramolecular complex comprising the LIM domains of the LIM-homeodomain protein Isl1 tethered to a peptide region of Ldb1 has been engineered, purified and crystallized. The orthorhombic crystals belonged to space groupP2221, with unit-cell parametersa= 57.2,b= 56.7,c= 179.8 Å, and diffracted to 3.10 Å resolution.

scholarly journals Effect of ionic liquid on the fluorescence of an intramolecular exciplex forming probe

2020 ◽  
Vol 19 (2) ◽  
pp. 251-260 ◽  
Author(s):  
Anita Yadav ◽  
Shruti Trivedi ◽  
V. Haridas ◽  
Jeremy B. Essner ◽  
Gary A. Baker ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Spectroscopic Properties ◽  
Protic Solvents ◽  
Intramolecular Complex

The effects of ionic liquid addition on the spectroscopic properties of a pyrene-tryptophan-containing fluorescent intramolecular complex in polar-aprotic and polar-protic solvents, specifically, acetonitrile and ethanol, are assessed.

Structure of the Tebbe reagent. An intramolecular complex?

1983 ◽  
Vol 2 (3) ◽  
pp. 457-459 ◽  
Author(s):  
Michelle M. Francl ◽  
Warren J. Hehre
Keyword(s):  
Intramolecular Complex

scholarly journals Divalent ligand for intramolecular complex formation to streptavidin

2005 ◽  
Vol 3 (13) ◽  
pp. 2393 ◽  
Author(s):  
Joan-Antoni Farrera ◽  
Pedro Hidalgo-Fernández ◽  
Jurry M. Hannink ◽  
Jurriaan Huskens ◽  
Alan E. Rowan ◽  
...  
Keyword(s):  
Complex Formation ◽  
Intramolecular Complex

A tryptophan-containing fluorescent intramolecular complex as a designer peptidic proton sensor

2016 ◽  
Vol 18 (22) ◽  
pp. 15046-15053 ◽  
Author(s):  
V. Haridas ◽  
Anita Yadav ◽  
Sakshi Sharma ◽  
Siddharth Pandey
Keyword(s):  
Molecular Scaffold ◽  
Intramolecular Complex

Pyrene and tryptophan groups judiciously placed on a molecular scaffold, namely, bispidine exhibited fluorescence due to the formation of an emissive intramolecular complex.

Unfolding and Targeting Thermodynamics of a DNA Intramolecular Complex with Joined Triplex–Duplex Domains

2018 ◽  
Vol 122 (3) ◽  
pp. 1102-1111
Author(s):  
Sarah E. Johnson ◽  
Calliste Reiling-Steffensmeier ◽  
Hui-Ting Lee ◽  
Luis A. Marky
Keyword(s):  
Intramolecular Complex

Photocyclisation of o-Xylylbischromones: Proximity Effect

2005 ◽  
Vol 2005 (11) ◽  
pp. 741-743 ◽  
Author(s):  
Satish C. Gupta ◽  
Mohamad Yusuf ◽  
Mandeep Thakur ◽  
Ramesh C. Kamboj
Keyword(s):  
Complex Formation ◽  
Proximity Effect ◽  
Intramolecular Complex ◽  
Chemical Efficiency

The photocyclisation of thiophene and furan substituted o-xylylbischromones is described. The reaction occurs through a 1,4-biradical species. The proximity of the two chromophores due to intramolecular complex formation affects the chemical efficiency of the reaction.

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