scholarly journals Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

2017 ◽  
Vol 8 (2) ◽  
pp. 226-234 ◽  
Author(s):  
Tadahiro Shinozawa ◽  
Koki Nakamura ◽  
Masanobu Shoji ◽  
Maya Morita ◽  
Maya Kimura ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Qt Prolongation ◽  
Drug Induced ◽  
Individual Susceptibility

scholarly journals An explainable algorithm for detecting drug-induced QT-prolongation at risk of torsades de pointes (TdP) regardless of heart rate and T-wave morphology

2021 ◽  
Vol 131 ◽  
pp. 104281
Author(s):  
Alaa Alahmadi ◽  
Alan Davies ◽  
Jennifer Royle ◽  
Leanna Goodwin ◽  
Katharine Cresswell ◽  
...  
Keyword(s):  
At Risk ◽  
Heart Rate ◽  
Torsades De Pointes ◽  
Qt Prolongation ◽  
Drug Induced ◽  
T Wave ◽  
Wave Morphology

Peripheral Autonomic Potentials in Primary Headache and Drug-Induced Headache

Cephalalgia ◽  
1998 ◽  
Vol 18 (4) ◽  
pp. 216-221 ◽  
Author(s):  
S Evers ◽  
H Voss ◽  
B Bauer ◽  
P Sörös ◽  
I-W Husstedt
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Drug Abuse ◽  
Healthy Subjects ◽  
Primary Headache ◽  
Tension Type Headache ◽  
Low Back ◽  
Drug Induced ◽  
Type Headache ◽  
Drug Induced Headache

Autonomic functions of different primary headache types have been investigated in several studies, most of them analyzing cardiovascular reflex mechanisms or biochemical changes. The results are contradictory; only in tension-type headache and in cluster headache has a sympathetic hypofunction been shown in a preponderance of studies. We analyzed the peripheral autonomous potentials (PAPs) in different primary headache types and in drug-induced headache and compared the results with those of healthy subjects and of patients with low back pain. Latencies of PAPs were significantly increased in all headache types but not in low back pain; amplitudes of PAPs did not show significant differences compared to healthy subjects. Patients with a long duration of drug abuse had increased PAP latencies, whereas patients with a high number of migraine attacks per year had decreased latencies. Our data suggest that sympathetic hypo-function as measured by PAP latencies is a general phenomenon in headache but not in all pain syndromes. Drug abuse leads to an increase of this hypofunction. While measuring PAPs is not an appropriate method by which to differentiate between headache disorders, it allows assessment of autonomic disturbances in primary and drug-induced headache.

Drug-induced QT Prolongation Atlas (DIQTA) for enhancing cardiotoxicity management

2021 ◽  
Author(s):  
Shihai Li ◽  
Zili Xu ◽  
Mingkun Guo ◽  
Menglong Li ◽  
Zhining Wen
Keyword(s):  
Qt Prolongation ◽  
Drug Induced
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