scholarly journals FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

2014 ◽  
Vol 2 (4) ◽  
pp. 414-426 ◽  
Author(s):  
Suchitra D. Gopinath ◽  
Ashley E. Webb ◽  
Anne Brunet ◽  
Thomas A. Rando
Keyword(s):  
Stem Cells ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Adult Muscle

Stem Cell Function, Self-Renewal, Heterogeneity, and Regenerative Potential in Skeletal Muscle Stem Cells

2012 ◽  
Vol 2 (1) ◽  
pp. 11-21
Author(s):  
Silvia Cristini ◽  
Giulio Alessandri ◽  
Francesco Acerbi ◽  
Daniela Tavian ◽  
Eugenio A. Parati ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Function ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

Stem Cell Function, Self-Renewal, Heterogeneity, and Regenerative Potential in Skeletal Muscle Stem Cells

2012 ◽  
Vol 2 (1) ◽  
pp. 11-21
Author(s):  
Silvia Cristini ◽  
Giulio Alessandri ◽  
Francesco Acerbi ◽  
Daniela Tavian ◽  
Eugenio A. Parati ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Function ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

scholarly journals Myogenin regulates a distinct genetic program in adult muscle stem cells

2008 ◽  
Vol 322 (2) ◽  
pp. 406-414 ◽  
Author(s):  
Eric Meadows ◽  
Jang-Hyeon Cho ◽  
Jesse M. Flynn ◽  
William H. Klein
Keyword(s):  
Stem Cells ◽  
Genetic Program ◽  
Muscle Stem Cells ◽  
Adult Muscle

An oscillatory network controlling self-renewal of skeletal muscle stem cells

2021 ◽  
pp. 112933
Author(s):  
Ines Lahmann ◽  
Yao Zhang ◽  
Katharina Baum ◽  
Jana Wolf ◽  
Carmen Birchmeier
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Self Renewal ◽  
Muscle Stem Cells ◽  
Oscillatory Network ◽  
Skeletal Muscle Stem Cells

scholarly journals APC is required for muscle stem cell proliferation and skeletal muscle tissue repair

2015 ◽  
Vol 210 (5) ◽  
pp. 717-726 ◽  
Author(s):  
Alice Parisi ◽  
Floriane Lacour ◽  
Lorenzo Giordani ◽  
Sabine Colnot ◽  
Pascal Maire ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Cycle Progression ◽  
Cell Types ◽  
Double Knockout ◽  
Muscle Stem Cells ◽  
Adult Muscle ◽  
Canonical Wnt

The tumor suppressor adenomatous polyposis coli (APC) is a crucial regulator of many stem cell types. In constantly cycling stem cells of fast turnover tissues, APC loss results in the constitutive activation of a Wnt target gene program that massively increases proliferation and leads to malignant transformation. However, APC function in skeletal muscle, a tissue with a low turnover rate, has never been investigated. Here we show that conditional genetic disruption of APC in adult muscle stem cells results in the abrogation of adult muscle regenerative potential. We demonstrate that APC removal in adult muscle stem cells abolishes cell cycle entry and leads to cell death. By using double knockout strategies, we further prove that this phenotype is attributable to overactivation of β-catenin signaling. Our results demonstrate that in muscle stem cells, APC dampens canonical Wnt signaling to allow cell cycle progression and radically diverge from previous observations concerning stem cells in actively self-renewing tissues.

scholarly journals Myf5-Positive Satellite Cells Contribute to Pax7-Dependent Long-Term Maintenance of Adult Muscle Stem Cells

2013 ◽  
Vol 13 (6) ◽  
pp. 769
Author(s):  
Stefan Günther ◽  
Johnny Kim ◽  
Sawa Kostin ◽  
Christoph Lepper ◽  
Chen-Ming Fan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Satellite Cells ◽  
Muscle Stem Cells ◽  
Adult Muscle ◽  
Term Maintenance

scholarly journals Self-renewal and expansion of single transplanted muscle stem cells

Nature ◽  
2008 ◽  
Vol 456 (7221) ◽  
pp. 502-506 ◽  
Author(s):  
Alessandra Sacco ◽  
Regis Doyonnas ◽  
Peggy Kraft ◽  
Stefan Vitorovic ◽  
Helen M. Blau
Keyword(s):  
Stem Cells ◽  
Self Renewal ◽  
Muscle Stem Cells
Sign in / Sign up

Export Citation Format

Share Document