A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Liuliu Yang; Yuling Han; Benjamin E. Nilsson-Payant; Vikas Gupta; Pengfei Wang; Xiaohua Duan; Xuming Tang; Jiajun Zhu; Zeping Zhao; Fabrice Jaffré; Tuo Zhang; Tae Wan Kim; Oliver Harschnitz; David Redmond; Sean Houghton; Chengyang Liu; Ali Naji; Gabriele Ciceri; Sudha Guttikonda; Yaron Bram; Duc-Huy T. Nguyen; Michele Cioffi; Vasuretha Chandar; Daisy A. Hoagland; Yaoxing Huang; Jenny Xiang; Hui Wang; David Lyden; Alain Borczuk; Huanhuan Joyce Chen; Lorenz Studer; Fong Cheng Pan; David D. Ho; Benjamin R. tenOever; Todd Evans; Robert E. Schwartz; Shuibing Chen

doi:10.1016/j.stem.2020.06.015

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Cell Stem Cell ◽

10.1016/j.stem.2020.06.015 ◽

2020 ◽

Vol 27 (1) ◽

pp. 125-136.e7 ◽

Cited By ~ 68

Author(s):

Liuliu Yang ◽

Yuling Han ◽

Benjamin E. Nilsson-Payant ◽

Vikas Gupta ◽

Pengfei Wang ◽

...

Keyword(s):

Stem Cell ◽

Virus Infection ◽

Pluripotent Stem Cell ◽

Human Cells ◽

Human Pluripotent Stem Cell ◽

Model Virus

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Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Frontiers in Endocrinology ◽

10.3389/fendo.2020.585922 ◽

2020 ◽

Vol 11 ◽

Author(s):

Amin Ardestani ◽

Kathrin Maedler

Keyword(s):

Stem Cell ◽

Virus Infection ◽

Pluripotent Stem Cell ◽

Human Cells ◽

Human Pluripotent Stem Cell ◽

Model Virus

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Human Pluripotent Stem Cell Derived Organoid Models

10.1016/s0091-679x(20)x0006-9 ◽

2020 ◽

Keyword(s):

Stem Cell ◽

Pluripotent Stem Cell ◽

Human Pluripotent Stem Cell

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Regenerative potential of human pluripotent stem cell-derived MSCs in a Gunn rat liver injury model

Zeitschrift für Gastroenterologie ◽

10.1055/s-0035-1568010 ◽

2015 ◽

Vol 53 (12) ◽

Author(s):

LS Spitzhorn ◽

M Megges ◽

C Kordes ◽

I Sawitza ◽

S Götze ◽

...

Keyword(s):

Stem Cell ◽

Liver Injury ◽

Rat Liver ◽

Pluripotent Stem Cell ◽

Human Pluripotent Stem Cell ◽

Gunn Rat ◽

Injury Model

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Faculty Opinions recommendation of Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725876995.793513150 ◽

2016 ◽

Author(s):

Martin Fernandez-Zapico

Keyword(s):

Pancreatic Cancer ◽

Stem Cell ◽

Drug Screening ◽

Pluripotent Stem Cell ◽

Human Pluripotent Stem Cell ◽

Cancer Modeling ◽

Ductal Pancreatic Cancer ◽

Tumor Organoids

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Faculty Opinions recommendation of Extracellular Matrix-Mediated Maturation of Human Pluripotent Stem Cell-Derived Cardiac Monolayer Structure and Electrophysiological Function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726282589.793518038 ◽

2016 ◽

Author(s):

George Truskey

Keyword(s):

Extracellular Matrix ◽

Stem Cell ◽

Pluripotent Stem Cell ◽

Human Pluripotent Stem Cell

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Faculty Opinions recommendation of Functional characterization of human pluripotent stem cell-derived arterial endothelial cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727798197.793534557 ◽

2017 ◽

Author(s):

George Truskey

Keyword(s):

Endothelial Cells ◽

Stem Cell ◽

Pluripotent Stem Cell ◽

Functional Characterization ◽

Human Pluripotent Stem Cell ◽

Arterial Endothelial Cells

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Faculty Opinions recommendation of A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734438486.793570764 ◽

2020 ◽

Author(s):

Warren Grayson

Keyword(s):

Skeletal Muscle ◽

Stem Cell ◽

Cell Line ◽

Pluripotent Stem Cell ◽

Human Pluripotent Stem Cell ◽

Stem Cell Line ◽

Prospective Isolation

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Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

Journal of Hepatology ◽

10.1016/j.jhep.2019.06.030 ◽

2019 ◽

Vol 71 (5) ◽

pp. 970-985 ◽

Cited By ~ 20

Author(s):

Seon Ju Mun ◽

Jae-Sung Ryu ◽

Mi-Ok Lee ◽

Ye Seul Son ◽

Soo Jin Oh ◽

...

Keyword(s):

Stem Cell ◽

Pluripotent Stem Cell ◽

Human Pluripotent Stem Cell ◽

Liver Organoids

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Advanced techniques and awaited clinical applications for human pluripotent stem cell differentiation into hepatocytes

Hepatology ◽

10.1002/hep.31705 ◽

2021 ◽

Author(s):

Eléanor Luce ◽

Antonietta Messina ◽

Jean‐Charles Duclos‐Vallée ◽

Anne Dubart‐Kupperschmitt

Keyword(s):

Stem Cell ◽

Cell Differentiation ◽

Pluripotent Stem Cell ◽

Stem Cell Differentiation ◽

Clinical Applications ◽

Human Pluripotent Stem Cell

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Establishment of an in vitro safety assessment model for lipid-lowering drugs using same-origin human pluripotent stem cell-derived cardiomyocytes and endothelial cells

Acta Pharmacologica Sinica ◽

10.1038/s41401-021-00621-8 ◽

2021 ◽

Author(s):

Xuan Ni ◽

Zhuang-zhuang Yang ◽

Ling-qun Ye ◽

Xing-long Han ◽

Dan-dan Zhao ◽

...

Keyword(s):

Endothelial Cells ◽

Stem Cell ◽

Pluripotent Stem Cell ◽

Safety Assessment ◽

Assessment Model ◽

Lipid Lowering ◽

Human Pluripotent Stem Cell ◽

Lipid Lowering Drugs

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