scholarly journals Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities

2018 ◽  
Vol 23 (2) ◽  
pp. 210-225.e6 ◽  
Author(s):  
Austin I. McDonald ◽  
Aditya S. Shirali ◽  
Raquel Aragón ◽  
Feiyang Ma ◽  
Gloria Hernandez ◽  
...  
Keyword(s):  
Endothelial Regeneration ◽  
Biphasic Process ◽  
Large Vessels

Diagnostics of kidney damage in the medium and large vessels vasculitis - review and presentation of three cases

2020 ◽  
Vol 22 (1) ◽  
pp. 108-130
Author(s):  
E.V. Zakharova ◽  
◽  
T.A. Makarova ◽  
E.S. Leonova ◽  
E.S. Stolyarevich ◽  
...  
Keyword(s):  
Kidney Damage ◽  
Large Vessels

scholarly journals Endometrial Perivascular Progenitor Cells and Uterus Regeneration

2021 ◽  
Vol 11 (6) ◽  
pp. 477
Author(s):  
Shiyuan Li ◽  
Lijun Ding
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Embryo Implantation ◽  
Endometrial Receptivity ◽  
Perivascular Cells ◽  
Asherman’S Syndrome ◽  
Outermost Layer ◽  
Adventitial Cells ◽  
Structure And Functions ◽  
Large Vessels

Ovarian steroid-regulated cyclical regeneration of the endometrium is crucial for endometrial receptivity and embryo implantation, and it is dependent on the dynamic remodeling of the endometrial vasculature. Perivascular cells, including pericytes surrounding capillaries and microvessels and adventitial cells located in the outermost layer of large vessels, show properties of mesenchymal stem cells, and they are thus promising candidates for uterine regeneration. In this review, we discuss the structure and functions of the endometrial blood vasculature and their roles in endometrial regeneration, the main biomarkers and characteristics of perivascular cells in the endometrium, and stem cell-based angiogenetic therapy for Asherman’s syndrome.

scholarly journals POS0821 THE DIFFERENT SUBTYPES OF GIANT CELL ARTERITIS BY ULTRASOUND: RESULTS FROM A FAST-TRACK CLINIC

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 664.3-664
Author(s):  
I. Monjo ◽  
E. Fernández-Fernández ◽  
J. Ortega ◽  
E. De Miguel
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Fast Track ◽  
Carotid Arteries ◽  
Imaging Techniques ◽  
Vascular Involvement ◽  
Temporal Arteries ◽  
Halo Sign ◽  
Cranial Vessels ◽  
Large Vessels

Background:Giant cell arteritis (GCA) is a vasculitis that affects the medium and large vessels (LV). Although cranial artery involvement is better known, awareness of the importance of LV involvement is increasing. Imaging techniques currently constitute the basis for the diagnosis of LV-GCA and have improved its diagnosis and prevalence. In recent years, differences in clinical patterns and different inflammatory and etiopathogenic mechanisms of the disease have been suggested. Therefore, improving sensitivity to diagnosis is essential to improve the knowledge and care of our population.Objectives:The aim of this study was to know the prevalence of the different ultrasound patterns of GCA in our area.Methods:Retrospective records of available data were collected from all patients referred to our ACG fast track clinic in the past three years. The clinical and laboratory characteristics were evaluated at the time of referral. All patients underwent an ultrasound scan of cranial vessels (superficial temporal arteries (TA) and their frontal and parietal branches) and large vessels (axillary, subclavian and carotid arteries). The doctor confirmed the GCA diagnosis after at least six months of follow-up. The OMERACT definitions of halo sign with a hypoechoic wall thickness ≥ 0.34 mm were used for TA pathology for the ultrasound diagnosis of GCA and for axillary, subclavian and carotid arteries and homogeneous hypoechoic thicknesses ≥ 1 mm of the arterial wall were applied. Atherosclerosis lesions were evaluated to detect this disease as a possible false positive halo sign. An Esaote Mylab Twice with a 13 MHz probe in BT and 22 MHz for cranial vessels in 2017-2019 and an Esaote Mylab X8plus with a 15 MHz probe for BT and a 24 MHz probe for cranial arteries in 2019-2020 were used by two rheumatologist with long experience in ACG ultrasound.Results:A total of 261 patients (180 women / 81 men) with suspected GCA were evaluated in our fast track clinic. The mean age (± SD) was 76 ± 9.2 years and CRP at diagnosis was 75.7 ± 68.6 mg/L. The time elapsed since the first symptoms was less than 6, 6-12, 12-24 or >24 weeks in 37.5%, 19.9%, 12.3% and 15.7% respectively. Of the 261 cases explored, 160 had GCA, of which 102 were women and 58 men, and had a mean age of 77.21 ± 7.9 years. The ultrasound patterns of GCA were: 71 patients had exclusive involvement of the TA (cranial-GCA), 54 had a mixed pattern with involvement of both TA and LV (mixed-CGA), and 35 had isolated involvement of the LV (LV-GCA). That is, 125 patients had cranial involvement with or without LV involvement and 89 had LV-GCA associated or not with cranial involvement (Figure 1).Figure 1.Ultrasound patters of GCAConclusion:Ultrasound is a useful tool for the screening of GCA and its different subtypes of vascular involvement. The isolated cranial subtype or associated with LV-GCA is the most common (78% of cases), but LV-GCA is also very common (55.6% of cases of GCA) and 21.9% presents as an isolated LV-GCA standard. The LV arteries should be included in the ultrasound examination for suspected GCA.Disclosure of Interests:Irene Monjo Speakers bureau: Roche, Novartis, UCB, Gedeon Richter, Consultant of: Roche, Elisa Fernández-Fernández: None declared, Javier Ortega: None declared, Eugenio de Miguel Speakers bureau: AbbVie, Novartis, Pfizer, MSD, BMS, UCB, Roche, Grunental, Janssen, Sanofi, Paid instructor for: Janssen, Novartis, Roche, Consultant of: AbbVie, Novartis, Pfizer, Galapagos, Grant/research support from: Abbvie, Novartis, Pfizer

scholarly journals Silk Fibroin Films for Corneal Endothelial Regeneration: Transplant in a Rabbit Descemet Membrane Endothelial Keratoplasty

2017 ◽  
Vol 58 (9) ◽  
pp. 3357 ◽  
Author(s):  
Natalia Vázquez ◽  
Carlos A. Rodríguez-Barrientos ◽  
Salvador D. Aznar-Cervantes ◽  
Manuel Chacón ◽  
José L. Cenis ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Endothelial Keratoplasty ◽  
Descemet Membrane Endothelial Keratoplasty ◽  
Descemet Membrane ◽  
Endothelial Regeneration

scholarly journals Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury

Gene Therapy ◽  
2006 ◽  
Vol 14 (5) ◽  
pp. 396-404 ◽  
Author(s):  
R Cooney ◽  
S O Hynes ◽  
F Sharif ◽  
L Howard ◽  
T O'Brien
Keyword(s):  
Gene Delivery ◽  
Intimal Hyperplasia ◽  
Balloon Injury ◽  
Endothelial Regeneration ◽  
Nos Isoforms
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