scholarly journals Skeletal Muscle Stem Cells from PSC-Derived Teratomas Have Functional Regenerative Capacity

2018 ◽  
Vol 23 (1) ◽  
pp. 74-85.e6 ◽  
Author(s):  
Sunny Sun-Kin Chan ◽  
Robert W. Arpke ◽  
Antonio Filareto ◽  
Ning Xie ◽  
Matthew P. Pappas ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Regenerative Capacity ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

scholarly journals Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration

Cells ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 183 ◽  
Author(s):  
David Lee ◽  
Akshay Bareja ◽  
David Bartlett ◽  
James White
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Stem Cell ◽  
Muscle Regeneration ◽  
Immune Cell ◽  
Regenerative Capacity ◽  
Adult Skeletal Muscle ◽  
Muscle Stem Cells ◽  
Age Related ◽  
Skeletal Muscle Stem Cells

Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function.

scholarly journals The effect of the muscle environment on the regenerative capacity of human skeletal muscle stem cells

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jinhong Meng ◽  
Maximilien Bencze ◽  
Rowan Asfahani ◽  
Francesco Muntoni ◽  
Jennifer E Morgan
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Human Skeletal Muscle ◽  
Regenerative Capacity ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

scholarly journals Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Mathilde Latil ◽  
Pierre Rocheteau ◽  
Laurent Châtre ◽  
Serena Sanulli ◽  
Sylvie Mémet ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Post Mortem ◽  
Dormant Cell ◽  
Regenerative Capacity ◽  
Muscle Stem Cells ◽  
Cell State ◽  
Skeletal Muscle Stem Cells

897 Inflammatory Bowel Disease Impairs the Regenerative Capacity of Skeletal Muscle Stem Cells

2014 ◽  
Vol 146 (5) ◽  
pp. S-158
Author(s):  
Johanna G. Palmadottir ◽  
Anu Maharjan ◽  
Andrew Draghi ◽  
Francisco A. Sylvester ◽  
Morgan E. Carlson
Keyword(s):  
Skeletal Muscle ◽  
Inflammatory Bowel Disease ◽  
Stem Cells ◽  
Bowel Disease ◽  
Regenerative Capacity ◽  
Muscle Stem Cells ◽  
Inflammatory Bowel ◽  
Skeletal Muscle Stem Cells
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