scholarly journals Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators

2016 ◽  
Vol 19 (4) ◽  
pp. 530-543 ◽  
Author(s):  
Lev Silberstein ◽  
Kevin A. Goncalves ◽  
Peter V. Kharchenko ◽  
Raphael Turcotte ◽  
Youmna Kfoury ◽  
...  
Keyword(s):  
Single Cell ◽  
Progenitor Cell ◽  
Single Cell Analysis ◽  
Cell Analysis

scholarly journals Single-cell analysis identifies EpCAM+/CDH6+/TROP-2− cells as human liver progenitors

2018 ◽  
Author(s):  
Joe M Segal ◽  
Daniel J Wesche ◽  
Maria Paola Serra ◽  
Bénédicte Oulès ◽  
Deniz Kent ◽  
...  
Keyword(s):  
Single Cell ◽  
Progenitor Cell ◽  
Healthy Adult ◽  
Single Cell Analysis ◽  
Cell Analysis ◽  
Adult Tissue ◽  
Adult Liver ◽  
Lineage Differentiation ◽  
Liver Progenitor Cell

AbstractThe liver is largely composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists as to whether a liver stem/progenitor cell capable of renewing both hepatocytes and BECs exists. Single cell RNA sequencing of freshly isolated human foetal and healthy adult liver identified hepatocyte, hepatoblast and liver progenitor cell (hLPC) populations. hLPCs, found at the interface between hepatocytes and bile ducts in both foetal and adult tissue, were distinguishable from BECs by their negative expression of TROP-2. Prospective isolation followed by in vitro culture demonstrated their potential for expansion and bi-lineage differentiation. The hLPC expression signature was also conserved within expanded cell populations specific to certain cases of liver injury and cancer. These data support the idea of a true progenitor existing within healthy adult liver that can be activated upon injury. Further work to define the mechanisms regulating hLPC behaviour could advance understanding of human development and disease.

scholarly journals Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney

Development ◽  
2018 ◽  
Vol 145 (16) ◽  
pp. dev164038 ◽  
Author(s):  
Rajasree Menon ◽  
Edgar A. Otto ◽  
Austin Kokoruda ◽  
Jian Zhou ◽  
Zidong Zhang ◽  
...  
Keyword(s):  
Single Cell ◽  
Progenitor Cell ◽  
Single Cell Analysis ◽  
Cell Analysis ◽  
Fetal Kidney ◽  
Lineage Specification ◽  
Cell Dynamics ◽  
Human Fetal Kidney

scholarly journals Multimodal single‐cell analysis reveals distinct radioresistant stem‐like and progenitor cell populations in murine glioma

Glia ◽  
2020 ◽  
Vol 68 (12) ◽  
pp. 2486-2502
Author(s):  
Jes Alexander ◽  
Quincey C. LaPlant ◽  
Siobhan S. Pattwell ◽  
Frank Szulzewsky ◽  
Patrick J. Cimino ◽  
...  
Keyword(s):  
Single Cell ◽  
Progenitor Cell ◽  
Single Cell Analysis ◽  
Cell Populations ◽  
Cell Analysis ◽  
Murine Glioma

Author response for "Immunocyte single cell analysis of vaccine‐induced narcolepsy"

2020 ◽  
Author(s):  
Alexander Lind ◽  
Falastin Salami ◽  
Anne‐Marie Landtblom ◽  
Lars Palm ◽  
Åke Lernmark ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Author Response ◽  
Cell Analysis
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