scholarly journals Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

2015 ◽  
Vol 17 (6) ◽  
pp. 663-674 ◽  
Author(s):  
Katarzyna Siudeja ◽  
Sonya Nassari ◽  
Louis Gervais ◽  
Patricia Skorski ◽  
Sonia Lameiras ◽  
...  
Keyword(s):  
Stem Cells ◽  
Somatic Mutation ◽  
Intestinal Stem Cells ◽  
Genetic Mosaicism

scholarly journals Early divergence of mutational processes in human fetal tissues

2019 ◽  
Vol 5 (5) ◽  
pp. eaaw1271 ◽  
Author(s):  
Ewart Kuijk ◽  
Francis Blokzijl ◽  
Myrthe Jager ◽  
Nicolle Besselink ◽  
Sander Boymans ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Fetal Liver ◽  
Mutation Accumulation ◽  
Intestinal Stem Cells ◽  
Adult Liver ◽  
Fetal Tissues ◽  
Genetic Mosaicism ◽  
Human Fetal Tissues ◽  
Mutational Processes

A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were about fivefold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells resembled that of adult intestinal stem cells, while the mutation spectrum of fetal liver stem cells is distinct from stem cells of the fetal intestine and the adult liver. Our analyses indicate that variation in mutational mechanisms, including oxidative stress and spontaneous deamination of methylated cytosines, contributes to the observed divergence in mutation accumulation patterns and drives genetic mosaicism in humans.

scholarly journals Evolution and genomic signatures of spontaneous somatic mutation in Drosophila intestinal stem cells

2021 ◽  
pp. gr.268441.120
Author(s):  
Nick Riddiford ◽  
Katarzyna Siudeja ◽  
Marius van den Beek ◽  
Benjamin Boumard ◽  
Allison J Bardin
Keyword(s):  
Stem Cells ◽  
Somatic Mutation ◽  
Intestinal Stem Cells ◽  
Genomic Signatures

scholarly journals Early divergence of mutational mechanisms drives genetic heterogeneity of fetal tissues

2018 ◽  
Author(s):  
Ewart Kuijk ◽  
Francis Blokzijl ◽  
Myrthe Jager ◽  
Nicolle Besselink ◽  
Sander Boymans ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Stem Cells ◽  
Fetal Liver ◽  
Mutation Accumulation ◽  
Intestinal Stem Cells ◽  
Fetal Tissues ◽  
Dna Mutations ◽  
Genetic Mosaicism ◽  
Human Fetal Development ◽  
Early Human

AbstractA developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were ~5-fold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells resembled that of adult intestinal stem cells, while the mutation spectrum of fetal liver stem cells is distinct from stem cells of the fetal intestine and the adult liver. Our analyses indicate that variation in mutational mechanisms, including oxidative stress and spontaneous deamination of methylated cytosines, contribute to the observed divergence in mutation accumulation patterns and drive genetic mosaicism in humans.One Sentence SummaryLiver and intestinal cells accumulate elevated amounts and diverged types of somatic DNA mutations during early human fetal development

Epithelial Regeneration after Doxorubicin Arises Primarily from Early Progeny of Active Intestinal Stem Cells

2020 ◽  
Author(s):  
Breanna Sheahan ◽  
Ally N. Freeman ◽  
Theresa M. Keeley ◽  
Linda C. Samuelson ◽  
Jatin Roper ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intestinal Stem Cells ◽  
Epithelial Regeneration
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