scholarly journals Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

2015 ◽  
Vol 16 (5) ◽  
pp. 517-532 ◽  
Author(s):  
Kazuki Kurimoto ◽  
Yukihiro Yabuta ◽  
Katsuhiko Hayashi ◽  
Hiroshi Ohta ◽  
Hiroshi Kiyonari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Chromatin Remodeling ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Cell Specification ◽  
Germ Cell Specification

scholarly journals Primordial Germ Cell Specification from Embryonic Stem Cells

PLoS ONE ◽  
2008 ◽  
Vol 3 (12) ◽  
pp. e4013 ◽  
Author(s):  
Wei Wei ◽  
Tingting Qing ◽  
Xin Ye ◽  
Haisong Liu ◽  
Donghui Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Embryonic Stem ◽  
Cell Specification ◽  
Germ Cell Specification

scholarly journals Post-meiotic male germ cell differentiation of mouse embryonic stem cells by exposure to conditioned medium

2019 ◽  
Vol 112 (3) ◽  
pp. e101-e102
Author(s):  
Aysha Trout ◽  
Philip Xie ◽  
Alessandra Parrella ◽  
Zev Rosenwaks ◽  
Gianpiero D. Palermo
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Conditioned Medium ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Male Germ Cell ◽  
Germ Cell Differentiation

scholarly journals Reconstitution of male germline cell specification from mouse embryonic stem cells using defined factors in vitro

2019 ◽  
Vol 26 (10) ◽  
pp. 2115-2124 ◽  
Author(s):  
Na Li ◽  
Wentao Ma ◽  
Qiaoyan Shen ◽  
Mengfei Zhang ◽  
Zhaoyu Du ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Germline Cell ◽  
Cell Specification ◽  
Male Germline

scholarly journals Resf1 supports embryonic stem cell self-renewal and effective germline entry

2021 ◽  
Author(s):  
Matus Vojtek ◽  
Ian Chambers
Keyword(s):  
Stem Cells ◽  
Germ Cell ◽  
Germ Line ◽  
Primordial Germ Cell ◽  
Embryonic Stem ◽  
Cell Specification ◽  
Self Renewal ◽  
Downstream Target ◽  
Germ Cell Specification

Retroelement silencing factor 1 (Resf1) interacts with the key regulators of mouse embryonic stem cells (ESCs) Oct4 and Nanog, and its absence results in sterility of mice. However, the function of Resf1 in ESCs and germ line specification is poorly understood. In this study, we used Resf1 knockout cell lines to determine the requirements of RESF1 for ESCs self-renewal and for in vitro specification of ESCs into primordial germ cell-like cells (PGCLCs). We found that deletion of Resf1 in ESCs cultured in serum and LIF reduces self-renewal potential whereas episomal expression of RESF1 has a modest positive effect on ESC self-renewal. In addition, RESF1 is not required for the capacity of NANOG and its downstream target ESRRB to drive self-renewal in the absence of LIF. However, Resf1 deletion reduces efficiency of PGCLC differentiation in vitro. These results identify Resf1 as a novel player in the regulation of pluripotent stem cells and germ cell specification.

scholarly journals Induction of Primordial Germ Cell-Like Cells From Mouse Embryonic Stem Cells by ERK Signal Inhibition

Stem Cells ◽  
2014 ◽  
Vol 32 (10) ◽  
pp. 2668-2678 ◽  
Author(s):  
Tohru Kimura ◽  
Yoshiaki Kaga ◽  
Hiroshi Ohta ◽  
Mika Odamoto ◽  
Yoichi Sekita ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells

Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation

2010 ◽  
Vol 392 (3) ◽  
pp. 311-316 ◽  
Author(s):  
Noriko Yamano ◽  
Tohru Kimura ◽  
Shoko Watanabe-Kushima ◽  
Takashi Shinohara ◽  
Toru Nakano
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Primordial Germ Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Akt Activation
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