scholarly journals Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm

2015 ◽  
Vol 16 (2) ◽  
pp. 148-157 ◽  
Author(s):  
Gregory L. Szot ◽  
Mahesh Yadav ◽  
Jiena Lang ◽  
Evert Kroon ◽  
Justin Kerr ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Tolerance Induction ◽  
Diabetes In Mice

scholarly journals A Combination of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Transplant with LDHA-Repressing miRNA Can Attenuate High-Fat Diet Induced Type II Diabetes in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Yunya Chen ◽  
Xiujie Wang ◽  
Xinyu Shao
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
High Fat Diet ◽  
Type Ii Diabetes ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
High Fat ◽  
Diabetes In Mice

Type II diabetes mellitus (T2D) is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. The deficit and dysfunction of insulin secretingβ-cell are signature symptom for T2D. Additionally, in pancreaticβ-cell, a small group of genes which are abundantly expressed in most other tissues are highly selectively repressed. Lactate dehydrogenase A (LDHA) is one of such genes. Upregulation of LDHA is found in both human T2D and rodent T2D models. In this study, we identified a LDHA-suppressing microRNA (hsa-miR-590-3p) and used it together with human embryonic stem cell (hESC) derived pancreatic endoderm (PE) transplantation into a high-fat diet induced T2D mouse model. The procedure significantly improved glucose metabolism and other symptoms of T2D. Our findings support the potential T2D treatment using the combination of microRNA and hESC-differentiated PE cells.

scholarly journals Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Diabetes ◽  
2012 ◽  
Vol 61 (8) ◽  
pp. 2016-2029 ◽  
Author(s):  
A. Rezania ◽  
J. E. Bruin ◽  
M. J. Riedel ◽  
M. Mojibian ◽  
A. Asadi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Pancreatic Progenitors ◽  
Diabetes In Mice

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

2020 ◽  
Author(s):  
Wamaitha SE ◽  
Grybel KJ ◽  
Alanis-Lobato G ◽  
Gerri C ◽  
Ogushi S ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Self Renewal
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