scholarly journals Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

2014 ◽  
Vol 15 (2) ◽  
pp. 169-184 ◽  
Author(s):  
Leal Oburoglu ◽  
Saverio Tardito ◽  
Vanessa Fritz ◽  
Stéphanie C. de Barros ◽  
Peggy Merida ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Glutamine Metabolism ◽  
Lineage Specification ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage

scholarly journals Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification

2014 ◽  
Vol 15 (5) ◽  
pp. 666-668
Author(s):  
Leal Oburoglu ◽  
Saverio Tardito ◽  
Vanessa Fritz ◽  
Stéphanie C. de Barros ◽  
Peggy Merida ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Glutamine Metabolism ◽  
Lineage Specification ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage

Hematopoietic stem cell lineage specification

2016 ◽  
Vol 23 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Marie Pouzolles ◽  
Leal Oburoglu ◽  
Naomi Taylor ◽  
Valérie S. Zimmermann
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Lineage Specification ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage

The Mouse Hematopoietic Stem Cell Lineage Fails to Develop Beyond the Pro-HSC Stage in the Absence of Blood Flow

2018 ◽  
Vol 64 ◽  
pp. S41-S42
Author(s):  
Emanuele Azzoni ◽  
Vincent Frontera ◽  
Joe Harman ◽  
Sten Eirik Jacobsen ◽  
Marella De Bruijn
Keyword(s):  
Blood Flow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage ◽  
Mouse Hematopoietic Stem Cell

scholarly journals Early ontogenic origin of the hematopoietic stem cell lineage

2012 ◽  
Vol 109 (12) ◽  
pp. 4515-4520 ◽  
Author(s):  
Y. Tanaka ◽  
M. Hayashi ◽  
Y. Kubota ◽  
H. Nagai ◽  
G. Sheng ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage

scholarly journals G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment

2012 ◽  
Vol 26 (22) ◽  
pp. 2499-2511 ◽  
Author(s):  
X. Chen ◽  
K. Skutt-Kakaria ◽  
J. Davison ◽  
Y.-L. Ou ◽  
E. Choi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Lineage Commitment ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage

Epigenetic Mechanisms: Role in Hematopoietic Stem Cell Lineage Commitment and Differentiation

2018 ◽  
Vol 19 (14) ◽  
pp. 1683-1695 ◽  
Author(s):  
Sanjeev Raghuwanshi ◽  
Swati Dahariya ◽  
Ravinder Kandi ◽  
Usha Gutti ◽  
Ram Babu Undi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Lineage ◽  
Lineage Commitment ◽  
Epigenetic Mechanisms ◽  
Hematopoietic Stem ◽  
Stem Cell Lineage

scholarly journals Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

Blood ◽  
2011 ◽  
Vol 118 (5) ◽  
pp. 1264-1273 ◽  
Author(s):  
Melanie G. Cornejo ◽  
Vinciane Mabialah ◽  
Stephen M. Sykes ◽  
Tulasi Khandan ◽  
Cristina Lo Celso ◽  
...  
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Hematopoietic Stem Cell ◽  
Stem Cell Differentiation ◽  
Notch Signaling Pathway ◽  
Developmental Pathways ◽  
Lineage Specification ◽  
Hematopoietic Stem

Abstract The NOTCH signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. However, the molecular basis for its role at the different steps of stem cell lineage commitment is unclear. We recently identified the NOTCH signaling pathway as a positive regulator of megakaryocyte lineage specification during hematopoiesis, but the developmental pathways that allow hematopoietic stem cell differentiation into the erythro-megakaryocytic lineages remain controversial. Here, we investigated the role of downstream mediators of NOTCH during megakaryopoiesis and report crosstalk between the NOTCH and PI3K/AKT pathways. We demonstrate the inhibitory role of phosphatase with tensin homolog and Forkhead Box class O factors on megakaryopoiesis in vivo. Finally, our data annotate developmental mechanisms in the hematopoietic system that enable a decision to be made either at the hematopoietic stem cell or the committed progenitor level to commit to the megakaryocyte lineage, supporting the existence of 2 distinct developmental pathways.

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