scholarly journals Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury

2011 ◽  
Vol 8 (5) ◽  
pp. 468-475 ◽  
Author(s):  
Frédéric Bretzner ◽  
Frédéric Gilbert ◽  
Françoise Baylis ◽  
Robert M. Brownstone
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Stem Cell Research ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Embryonic Stem Cell Research ◽  
Target Populations ◽  
Cord Injury

scholarly journals Human Embryonic Stem Cell–derived Neural Crest Cells Promote Sprouting and Motor Recovery Following Spinal Cord Injury in Adult Rats

2021 ◽  
Vol 30 ◽  
pp. 096368972098824
Author(s):  
Iwan Jones ◽  
Liudmila N. Novikova ◽  
Mikael Wiberg ◽  
Leif Carlsson ◽  
Lev N. Novikov
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Neural Crest ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Neural Crest Cells ◽  
Cell Based Therapy ◽  
Cord Injury

Spinal cord injury results in irreversible tissue damage and permanent sensorimotor impairment. The development of novel therapeutic strategies that improve the life quality of affected individuals is therefore of paramount importance. Cell transplantation is a promising approach for spinal cord injury treatment and the present study assesses the efficacy of human embryonic stem cell–derived neural crest cells as preclinical cell-based therapy candidates. The differentiated neural crest cells exhibited characteristic molecular signatures and produced a range of biologically active trophic factors that stimulated in vitro neurite outgrowth of rat primary dorsal root ganglia neurons. Transplantation of the neural crest cells into both acute and chronic rat cervical spinal cord injury models promoted remodeling of descending raphespinal projections and contributed to the partial recovery of forelimb motor function. The results achieved in this proof-of-concept study demonstrates that human embryonic stem cell–derived neural crest cells warrant further investigation as cell-based therapy candidates for the treatment of spinal cord injury.

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