scholarly journals Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

2010 ◽  
Vol 6 (2) ◽  
pp. 141-152 ◽  
Author(s):  
Nikki Charles ◽  
Tatsuya Ozawa ◽  
Massimo Squatrito ◽  
Anne-Marie Bleau ◽  
Cameron W. Brennan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Notch Signaling ◽  
Glioma Cells

scholarly journals CSIG-13. TRPM7 INDUCES TUMORIGENESIS AND STEMNESS THROUGH NOTCH ACTIVATION IN GLIOMA

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii30-ii30
Author(s):  
Jingwei Wan ◽  
Alyssa Guo ◽  
Mingli Liu
Keyword(s):  
Notch Signaling ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Inhibitory Effect ◽  
Notch Signaling Pathway ◽  
Normal Brain ◽  
Diffuse Astrocytoma ◽  
Notch1 Signaling ◽  
Signaling Activation ◽  
Proliferation And Invasion

Abstract Our group found that the inhibitory effect of TRPM7 on proliferation and invasion of human glioma cell is mediated by multiple mechanisms. TRPM7 regulates miR-28-5p expression, which suppresses cell proliferation and invasion in glioma cells by targeting Ras-related protein Rap1b. In particular, our group found that TRPM7 channels regulate glioma stem cell (GSC) growth/proliferation through STAT3 and Notch signaling. However, which Notch component(s) is crucial for its activity regulated by TRPM7, and its relationship with other GSC markers, such as CD133 and ALDH1, remain unclear. In the current project, we elucidate the mechanisms of TRMP7’s regulation of Notch signaling pathway that contribute to the development and progression of glioma and maintenance of self-renewal and tumorigenicity of GSC using multiple glioma cell lines (GC) with different molecular subtypes and GSCs derived from the GC lines. 1) We first analyzed TRPM7 expression using the Oncomine database (https://www.oncomine.org) and found that the TRPM7 mRNA expression is significantly increased in anaplastic astrocytoma, diffuse astrocytoma, and GBM patients compared to that in normal brain tissue controls. 2) TRPM7 is expressed in GBM, and its channel activity is correlated with Notch1 activation. Inhibition of TRPM7 downregulates Notch1 signaling, while upregulation of TRPM7 upregulates Notch1 signaling. 3) GSC markers, CD133 and ALDH1, are correlated with TRPM7 in GBM. 4) Targeting TRPM7 suppresses the growth and proliferation of glioma cells through G1/S arrests and apoptosis of glioma cells. 5) Targeting Notch1 suppresses the TRPM7-induced growth and proliferation of glioma cells, as well as the expression of GSC markers CD133 and ALDH1. In summary, TRPM7 is responsible for sustained Notch signaling activation, enhanced expression of GSC markers, and regulation of glioma stemness, which contribute to malignant glioma cell growth and invasion. Notch1 and ligand DII4 are key components that contribute GSC stemness.

effect of ginsenoside Rd on nitric oxide system induced by lipopolysaccharide plus TNF-α in C6 rat glioma cells

2003 ◽  
Vol 26 (5) ◽  
pp. 375-382 ◽  
Author(s):  
Seong-Soo Choi ◽  
Jin-Koo Lee ◽  
Eun-Jung Han ◽  
Ki-Jung Han ◽  
Han-Kyu Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glioma Cells ◽  
Oxide System ◽  
Rat Glioma ◽  
Ginsenoside Rd ◽  
Tnf Α ◽  
Nitric Oxide System

Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway

2014 ◽  
Vol 54 (11) ◽  
pp. 1363-1375 ◽  
Author(s):  
Meijuan Zou ◽  
Chen Hu ◽  
Qidong You ◽  
Aixia Zhang ◽  
Xuerong Wang ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Glioma Cells ◽  
Notch Signaling Pathway ◽  
Oroxylin A ◽  
Human Malignant Glioma ◽  
Malignant Glioma Cells

Nitric oxide and BCNU chemoresistance in C6 glioma cells: Role of S-nitrosoglutathione

2004 ◽  
Vol 36 (10) ◽  
pp. 1317-1328 ◽  
Author(s):  
Ding-I Yang ◽  
Jiu-Haw Yin ◽  
Tzyh-Chwen Ju ◽  
Long-Shiuh Chen ◽  
Chung Y. Hsu
Keyword(s):  
Nitric Oxide ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells

Induction of Nitric Oxide Synthase in Rat C6 Glioma Cells

2008 ◽  
Vol 62 (1) ◽  
pp. 315-321 ◽  
Author(s):  
Douglas L. Feinstein ◽  
Elena Galea ◽  
Steven Roberts ◽  
Henrik Berquist ◽  
Hong Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Oxide Synthase ◽  
Rat C6 Glioma

Cyclosporine enhances α1-adrenoceptor-mediated nitric oxide production in C6 glioma cells

2000 ◽  
Vol 407 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Hiroaki Ikesue ◽  
Yasufumi Kataoka ◽  
Rikako Kawachi ◽  
Shinya Dohgu ◽  
Hideki Shuto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Nitric Oxide Production ◽  
Oxide Production
Sign in / Sign up

Export Citation Format

Share Document