scholarly journals Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

2009 ◽  
Vol 4 (6) ◽  
pp. 559-567 ◽  
Author(s):  
Inga Hofmann ◽  
Elizabeth H. Stover ◽  
Dana E. Cullen ◽  
Junhao Mao ◽  
Kelly J. Morgan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hedgehog Signaling ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Murine Hematopoietic Stem Cell

scholarly journals Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

2009 ◽  
Vol 4 (6) ◽  
pp. 548-558 ◽  
Author(s):  
Jie Gao ◽  
Stephanie Graves ◽  
Ute Koch ◽  
Suqing Liu ◽  
Vladimir Jankovic ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hedgehog Signaling ◽  
Cell Function ◽  
Hematopoietic Stem

scholarly journals ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells

Blood ◽  
2017 ◽  
Vol 130 (5) ◽  
pp. 619-624 ◽  
Author(s):  
Brian S. Garrison ◽  
Adrian P. Rybak ◽  
Isabel Beerman ◽  
Balthasar Heesters ◽  
Francois E. Mercier ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Human Cells ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Murine Hematopoietic Stem Cell

Key Points ZFP521 regulates HSC self-renewal and differentiation. ZFP521 facilitates leukemogenesis in an MLL-AF9–mediated leukemia model.

scholarly journals Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function

2017 ◽  
Vol 1 (26) ◽  
pp. 2520-2528 ◽  
Author(s):  
Safa F. Mohamad ◽  
Linlin Xu ◽  
Joydeep Ghosh ◽  
Paul J. Childress ◽  
Irushi Abeysekera ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Murine Hematopoietic Stem Cell

Key Points OM, osteoblast, and megakaryocyte interactions regulate HSC function in the niche. OMs differ functionally and phenotypically from BM-derived macrophages.

Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo

2017 ◽  
Vol 55 ◽  
pp. 34-44.e2 ◽  
Author(s):  
Matilda Billing ◽  
Emma Rörby ◽  
Maria Dahl ◽  
Ulrika Blank ◽  
Silja Andradottír ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Murine Hematopoietic Stem Cell

scholarly journals Prostaglandin E2 Enhances Aged Hematopoietic Stem Cell Function

2021 ◽  
Author(s):  
Andrea M. Patterson ◽  
P. Artur Plett ◽  
Carol H. Sampson ◽  
Edward Simpson ◽  
Yunlong Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Prostaglandin E2 ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem

scholarly journals Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease

Anemia ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Elisabeth H. Javazon ◽  
Mohamed Radhi ◽  
Bagirath Gangadharan ◽  
Jennifer Perry ◽  
David R. Archer
Keyword(s):  
Cell Cycle ◽  
Lipid Peroxidation ◽  
Bone Marrow ◽  
Stem Cell ◽  
Sickle Cell Disease ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Cell Disease ◽  
Hematopoietic Progenitor ◽  
Hematopoietic Stem

Previous studies have shown that the sickle environment is highly enriched for reactive oxygen species (ROS). We examined the oxidative effects of sickle cell disease on hematopoietic stem cell function in a sickle mouse model.In vitrocolony-forming assays showed a significant decrease in progenitor colony formation derived from sickle compared to control bone marrow (BM). Sickle BM possessed a significant decrease in the KSL (c-kit+, Sca-1+, Lineage−) progenitor population, and cell cycle analysis showed that there were fewer KSL cells in the G0phase of the cell cycle compared to controls. We found a significant increase in both lipid peroxidation and ROS in sickle-derived KSL cells.In vivoanalysis demonstrated that normal bone marrow cells engraft with increased frequency into sickle mice compared to control mice. Hematopoietic progenitor cells derived from sickle mice, however, demonstrated significant impairment in engraftment potential. We observed partial restoration of engraftment by n-acetyl cysteine (NAC) treatment of KSL cells prior to transplantation. Increased intracellular ROS and lipid peroxidation combined with improvement in engraftment following NAC treatment suggests that an altered redox environment in sickle mice affects hematopoietic progenitor and stem cell function.

Loss of FancC Function Results in Decreased Hematopoietic Stem Cell Repopulating Ability

Blood ◽  
1999 ◽  
Vol 94 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Laura S. Haneline ◽  
Troy A. Gobbett ◽  
Rema Ramani ◽  
Madeleine Carreau ◽  
Manuel Buchwald ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Genetic Disorder ◽  
Test Cell ◽  
Hematopoietic Stem ◽  
Murine Homologue ◽  
Complex Genetic Disorder

Fanconi anemia (FA) is a complex genetic disorder characterized by progressive bone marrow (BM) aplasia, chromosomal instability, and acquisition of malignancies, particularly myeloid leukemia. We used a murine model containing a disruption of the murine homologue ofFANCC (FancC) to evaluate short- and long-term multilineage repopulating ability of FancC −/− cells in vivo. Competitive repopulation assays were conducted where “test”FancC −/− or FancC +/+ BM cells (expressing CD45.2) were cotransplanted with congenic competitor cells (expressing CD45.1) into irradiated mice. In two independent experiments, we determined that FancC −/− BM cells have a profound decrease in short-term, as well as long-term, multilineage repopulating ability. To determine quantitatively the relative production of progeny cells by each test cell population, we calculated test cell contribution to chimerism as compared with 1 × 105 competitor cells. We determined that FancC −/− cells have a 7-fold to 12-fold decrease in repopulating ability compared with FancC +/+cells. These data indicate that loss of FancC function results in reduced in vivo repopulating ability of pluripotential hematopoietic stem cells, which may play a role in the development of the BM failure in FA patients. This model system provides a powerful tool for evaluation of experimental therapeutics on hematopoietic stem cell function.

scholarly journals 193Normal hematopoietic stem cell function in mice following treatment with bortezomib

2003 ◽  
Vol 9 (2) ◽  
pp. 121 ◽  
Author(s):  
M. Pitzgerald ◽  
C. Fraser ◽  
I. Webb ◽  
D. Schenkein ◽  
D. Esseltine ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem

scholarly journals Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis

2018 ◽  
Vol 22 (2) ◽  
pp. 277 ◽  
Author(s):  
Maria Kleppe ◽  
Matthew H. Spitzer ◽  
Sheng Li ◽  
Corinne E. Hill ◽  
Lauren Dong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem
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