scholarly journals Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

2008 ◽  
Vol 2 (3) ◽  
pp. 274-283 ◽  
Author(s):  
Heather E. Fleming ◽  
Viktor Janzen ◽  
Cristina Lo Celso ◽  
Jun Guo ◽  
Kathleen M. Leahy ◽  
...  
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Hematopoietic Stem Cell ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Quiescence ◽  
Cell Quiescence

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

Blood ◽  
2013 ◽  
Vol 121 (5) ◽  
pp. 759-769 ◽  
Author(s):  
Catherine E. Forristal ◽  
Ingrid G. Winkler ◽  
Bianca Nowlan ◽  
Valerie Barbier ◽  
Gail Walkinshaw ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Protein Stabilization ◽  
Hematopoietic Stem ◽  
Stem Cell Quiescence ◽  
Key Points ◽  
Cell Quiescence

Key Points HIF-1α protein stabilization increases HSC quiescence in vivo. HIF-1α protein stabilization increases HSC resistance to irradiation and accelerates recovery.

scholarly journals Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo

2019 ◽  
Vol 116 (4) ◽  
pp. 1447-1456 ◽  
Author(s):  
Rong Lu ◽  
Agnieszka Czechowicz ◽  
Jun Seita ◽  
Du Jiang ◽  
Irving L. Weissman
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Hematopoietic Stem Cells ◽  
Hematopoietic Stem Cell ◽  
Lineage Commitment ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Hematopoietic System ◽  
Different Levels

While the aggregate differentiation of the hematopoietic stem cell (HSC) population has been extensively studied, little is known about the lineage commitment process of individual HSC clones. Here, we provide lineage commitment maps of HSC clones under homeostasis and after perturbations of the endogenous hematopoietic system. Under homeostasis, all donor-derived HSC clones regenerate blood homogeneously throughout all measured stages and lineages of hematopoiesis. In contrast, after the hematopoietic system has been perturbed by irradiation or by an antagonistic anti-ckit antibody, only a small fraction of donor-derived HSC clones differentiate. Some of these clones dominantly expand and exhibit lineage bias. We identified the cellular origins of clonal dominance and lineage bias and uncovered the lineage commitment pathways that lead HSC clones to different levels of self-renewal and blood production under various transplantation conditions. This study reveals surprising alterations in HSC fate decisions directed by conditioning and identifies the key hematopoiesis stages that may be manipulated to control blood production and balance.

scholarly journals Cyclin E1 regulates hematopoietic stem cell quiescence

Cell Cycle ◽  
2013 ◽  
Vol 12 (23) ◽  
pp. 3588-3588 ◽  
Author(s):  
Senthil Raja Jayapal ◽  
Philipp Kaldis
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Cyclin E1 ◽  
Stem Cell Quiescence ◽  
Cell Quiescence

Hematopoietic stem cell quiescence and function are controlled by the CYLD–TRAF2–p38MAPK pathway

2015 ◽  
Vol 209 (1) ◽  
pp. 2091OIA63 ◽  
Author(s):  
Melania Tesio ◽  
Yilang Tang ◽  
Katja Müdder ◽  
Massimo Saini ◽  
Lisa von Paleske ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Quiescence ◽  
Cell Quiescence ◽  
P38mapk Pathway ◽  
And Function

Megakaryocytes regulate hematopoietic stem cell quiescence via CXCL4 secretion

2014 ◽  
Vol 42 (8) ◽  
pp. S18 ◽  
Author(s):  
Ingmar Bruns ◽  
Daniel Lucas ◽  
Sandra Pinho ◽  
Jalal Ahmed ◽  
Michele Lambert ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Quiescence ◽  
Cell Quiescence
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