scholarly journals Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis

2007 ◽  
Vol 1 (4) ◽  
pp. 470-478 ◽  
Author(s):  
Monica Boyle ◽  
Chihunt Wong ◽  
Michael Rocha ◽  
D. Leanne Jones
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Self Renewal ◽  
Drosophila Testis ◽  
Cell Niche

Wnt6 regulates the homeostasis of the stem cell niche via Rac1-and Cdc42-mediated noncanonical Wnt signalling pathways in Drosophila testis

2021 ◽  
Vol 402 (1) ◽  
pp. 112511
Author(s):  
Min Wang ◽  
Xiaojin Luan ◽  
Yidan Yan ◽  
Qianwen Zheng ◽  
Wanyin Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Wnt Signalling ◽  
Signalling Pathways ◽  
Drosophila Testis ◽  
Cell Niche

scholarly journals Lin28 is a critical factor in the function and aging of Drosophila testis stem cell niche

Aging ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 855-873
Author(s):  
Perinthottathil Sreejith ◽  
Wijeong Jang ◽  
Van To ◽  
Yong Hun Jo ◽  
Benoit Biteau ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Critical Factor ◽  
Drosophila Testis ◽  
Cell Niche

scholarly journals Extreme Divergence of Wolbachia Tropism for the Stem-Cell-Niche in the Drosophila Testis

2014 ◽  
Vol 10 (12) ◽  
pp. e1004577 ◽  
Author(s):  
Michelle E. Toomey ◽  
Horacio M. Frydman
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Drosophila Testis ◽  
Cell Niche

scholarly journals Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis

Nature ◽  
2008 ◽  
Vol 454 (7208) ◽  
pp. 1132-1136 ◽  
Author(s):  
Justin Voog ◽  
Cecilia D’Alterio ◽  
D. Leanne Jones
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Somatic Stem Cells ◽  
Drosophila Testis ◽  
Cell Niche

scholarly journals Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Aiguo Tian ◽  
Jin Jiang
Keyword(s):  
Stem Cell ◽  
Intestinal Epithelium ◽  
Stem Cell Niche ◽  
Daughter Cell ◽  
Cell Number ◽  
Bmp Signaling ◽  
Self Renewal ◽  
Type Iv ◽  
Signal Production ◽  
Cell Niche

Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP signaling is asymmetric between ISC and its differentiated daughter cell. Two BMP ligands, Dpp and Gbb, are produced by enterocytes and act in conjunction to promote ISC self-renewal by antagonizing Notch signaling. Furthermore, the basement membrane-associated type IV collagens regulate ISC self-renewal by confining higher BMP signaling to ISCs. The employment of gut epithelia as a niche for stem cell self-renewal may provide a mechanism for direct communication between the niche and the environment, allowing niche signal production and stem cell number to be fine-tuned in response to various physiological and pathological stimuli.

Gastrointestinal Stem Cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity

2006 ◽  
Vol 290 (2) ◽  
pp. G189-G193 ◽  
Author(s):  
Neil D. Theise
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Cell Biology ◽  
Stem Cell Niche ◽  
Progenitor Cell ◽  
Stem Cell Biology ◽  
Cell Plasticity ◽  
Self Renewal ◽  
Cell Niche

This essay will address areas of liver stem/progenitor cell studies in which consensus has emerged and in which controversy still prevails over consensus, but it will also highlight important themes that inevitably should be a focus of liver stem/progenitor cell investigations in coming years. Thus concepts regarding cell plasticity, the existence of a physiological/anatomic stem cell niche, and whether intrahepatic liver stem/progenitor cells comprise true stem cells or progenitor cells (or both) will be approached in some detail.

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