scholarly journals HIV/gp120 Decreases Adult Neural Progenitor Cell Proliferation via Checkpoint Kinase-Mediated Cell-Cycle Withdrawal and G1 Arrest

2007 ◽  
Vol 1 (2) ◽  
pp. 230-236 ◽  
Author(s):  
Shu-ichi Okamoto ◽  
Yeon-Joo Kang ◽  
Christopher W. Brechtel ◽  
Elisa Siviglia ◽  
Rossella Russo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
G1 Arrest ◽  
Checkpoint Kinase ◽  
Progenitor Cell Proliferation ◽  
Hiv Gp120

scholarly journals Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin

2017 ◽  
Vol 216 (7) ◽  
pp. 1975-1992 ◽  
Author(s):  
Yanxin Li ◽  
Jianwei Jiao
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Progenitor Cell ◽  
Neural Progenitor Cells ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Histone Chaperone ◽  
Epigenetic Mechanism ◽  
Progenitor Cell Proliferation ◽  
Early Neurogenesis

Histone cell cycle regulator (HIRA) is a histone chaperone and has been identified as an epigenetic regulator. Subsequent studies have provided evidence that HIRA plays key roles in embryonic development, but its function during early neurogenesis remains unknown. Here, we demonstrate that HIRA is enriched in neural progenitor cells, and HIRA knockdown reduces neural progenitor cell proliferation, increases terminal mitosis and cell cycle exit, and ultimately results in premature neuronal differentiation. Additionally, we demonstrate that HIRA enhances β-catenin expression by recruiting H3K4 trimethyltransferase Setd1A, which increases H3K4me3 levels and heightens the promoter activity of β-catenin. Significantly, overexpression of HIRA, HIRA N-terminal domain, or β-catenin can override neurogenesis abnormities caused by HIRA defects. Collectively, these data implicate that HIRA, cooperating with Setd1A, modulates β-catenin expression and then regulates neurogenesis. This finding represents a novel epigenetic mechanism underlying the histone code and has profound and lasting implications for diseases and neurobiology.

scholarly journals Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation

2006 ◽  
Vol 296 (2) ◽  
pp. 396-408 ◽  
Author(s):  
Zhongxian Jiao ◽  
Zheng Gang Zhang ◽  
Thomas J. Hornyak ◽  
Ann Hozeska ◽  
Rui Lan Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Dopachrome Tautomerase ◽  
Progenitor Cell Proliferation

FGF‐4 regulates neural progenitor cell proliferation and neuronal differentiation

2006 ◽  
Vol 20 (9) ◽  
pp. 1484-1485 ◽  
Author(s):  
Nobuyoshi Kosaka ◽  
Maho Kodama ◽  
Hideo Sasaki ◽  
Yusuke Yamamoto ◽  
Fumitaka Takeshita ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Neuronal Differentiation ◽  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Progenitor Cell Proliferation
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