scholarly journals Wip1 Phosphatase Regulates p53-Dependent Apoptosis of Stem Cells and Tumorigenesis in the Mouse Intestine

2007 ◽  
Vol 1 (2) ◽  
pp. 180-190 ◽  
Author(s):  
Oleg N. Demidov ◽  
Oleg Timofeev ◽  
Hnin N.Y. Lwin ◽  
Calvina Kek ◽  
Ettore Appella ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wip1 Phosphatase ◽  
Mouse Intestine

scholarly journals Protein arginine methyltransferase 1 regulates cell proliferation and differentiation in adult mouse adult intestine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lu Xue ◽  
Lingyu Bao ◽  
Julia Roediger ◽  
Yijun Su ◽  
Bingyin Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Intestinal Epithelium ◽  
Adult Stem Cells ◽  
Adult Mouse ◽  
Intestinal Development ◽  
Arginine Methyltransferase ◽  
Mouse Intestine ◽  
Protein Arginine Methyltransferase 1 ◽  
Crypt Base

Abstract Background Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of their development remain poorly understood in mammals. Earlier studies suggest that the formation of adult mouse intestinal stem cells takes place during the first few weeks after birth, the postembryonic period when plasma thyroid hormone (T3) levels are high. Furthermore, deficiency in T3 signaling leads to defects in adult mouse intestine, including reduced cell proliferation in the intestinal crypts, where stem cells reside. Our earlier studies have shown that protein arginine methyltransferase 1 (PRMT1), a T3 receptor coactivator, is highly expressed during intestinal maturation in mouse. Methods We have analyzed the expression of PRMT1 by immunohistochemistry and studied the effect of tissue-specific knockout of PRMT1 in the intestinal epithelium. Results We show that PRMT1 is expressed highly in the proliferating transit amplifying cells and crypt base stem cells. By using a conditional knockout mouse line, we have demonstrated that the expression of PRMT1 in the intestinal epithelium is critical for the development of the adult mouse intestine. Specific removal of PRMT1 in the intestinal epithelium results in, surprisingly, more elongated adult intestinal crypts with increased cell proliferation. In addition, epithelial cell migration along the crypt-villus axis and cell death on the villus are also increased. Furthermore, there are increased Goblet cells and reduced Paneth cells in the crypt while the number of crypt base stem cells remains unchanged. Conclusions Our finding that PRMT1 knockout increases cell proliferation is surprising considering the role of PRMT1 in T3-signaling and the importance of T3 for intestinal development, and suggests that PRMT1 likely regulates pathways in addition to T3-signaling to affect intestinal development and/or homeostasis, thus affecting cell proliferating and epithelial turn over in the adult.

scholarly journals Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

2016 ◽  
Vol 151 (4) ◽  
pp. 684-697.e12 ◽  
Author(s):  
Martijn A.J. Koppens ◽  
Gergana Bounova ◽  
Gaetano Gargiulo ◽  
Ellen Tanger ◽  
Hans Janssen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Polycomb Repressive Complex ◽  
Polycomb Repressive Complex 2 ◽  
Mouse Intestine

scholarly journals Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity

Oncogene ◽  
2014 ◽  
Vol 34 (24) ◽  
pp. 3164-3175 ◽  
Author(s):  
P Riemer ◽  
A Sreekumar ◽  
S Reinke ◽  
R Rad ◽  
R Schäfer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Transgenic Expression ◽  
Mouse Intestine

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Repair of deep skin burn defects with cultured epidermal stem cells and acellular amniotic membranes

2010 ◽  
Vol 34 (8) ◽  
pp. S39-S39
Author(s):  
Dewu Liu ◽  
Honglan Xiong ◽  
Yuangui Mao ◽  
Peixin Huang ◽  
Jianping Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Epidermal Stem Cells ◽  
Skin Burn ◽  
Amniotic Membranes

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent

Preliminary research of the aldosterone synthesized by bone morrow stem cells of adult male ratsin vitro

2010 ◽  
Vol 34 (8) ◽  
pp. S43-S43
Author(s):  
Wei‑ying Zou ◽  
Bei Yang ◽  
Xiuli Ni ◽  
Da‑lei Zhang ◽  
Lei Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adult Male ◽  
Preliminary Research ◽  
Bone Morrow
Sign in / Sign up

Export Citation Format

Share Document