An Understanding of Low-Carbohydrate, High-Fat Diets and Cancer

2006 ◽  
Vol 2 (3) ◽  
pp. 136-140
Author(s):  
Vasundara Venkateswaran ◽  
Ahmed Q. Haddad ◽  
Laurence H. Klotz ◽  
Rob Nam ◽  
Neil E. Fleshner
Keyword(s):  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

A Systematic Review of Low-Carbohydrate High-Fat Diets: Does the Research Evidence Support Practice?

2018 ◽  
Vol 118 (10) ◽  
pp. A126
Author(s):  
L. Ross ◽  
J. Musial ◽  
R. Hay ◽  
A. Cawte ◽  
D. McDermid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Research Evidence ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Very low-carbohydrate high-fat diets are superior to low-fat diets in improving cardiovascular markers: meta-analysis of large, long-term randomised controlled trials

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Teuta Gjuladin-Hellon ◽  
Ian Davies ◽  
Jackie Fealey ◽  
Alexander Montasem ◽  
Katie Lane
Keyword(s):  
Total Cholesterol ◽  
Randomised Controlled Trials ◽  
Fasting Glucose ◽  
Meta Analysis ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Randomised Controlled ◽  
Fat Diets

AbstractOur recent study (1) showed that the amount of dietary carbohydrates in obesity interventions has differential effects on cardiovascular risk markers (CVM) and effects magnitude depends on intervention duration. Very-low carbohydrate high-fat diets (VLCD) were superior in ameliorating lipid markers compared to high-carbohydrate low-fat diets (LFD).We updated our systematic review and meta-analysis to include long-term effects of VLCD (< 50 g /day) on weight, glucose, total cholesterol, insulin and blood pressure (BP) among overweight/obese adults in comparison to LFD.Medline, PubMed, Cochrane Central, and CINAHLPlus were searched to identify large (n > 100) randomised controlled trials (RCT) with duration ≥ 6 months. Risk of bias, a random effects model and subgroup analyses based on duration of follow-up were performed using Review Manager. Results were reported according to PRISMA.Four open label RCT (n = 723; 362 VLCD; 361 LFD) with some form of behavioral intervention and duration 6–24 months were identified. VLCD showed more favorable effects on diastolic BP at 6 months (-1.96; 95%CI, -2.99 to 00.93; P = 0.0002) and 24 months (-2.69; 95%CI, -4.87 to -0.51; P = 0.001), near significant level at 12 months (-1.79; 95%CI, -3.56 to 0.04; P = 0.05) and an overall total favourable effect (-1.98; 95%CI, -2.73 to -1.22). The decrease in systolic BP was greater among VLCD for the whole period and the overall total effect reached the level of significance (-1.76; 95%CI, -3.56 to 0.04; P = 0.05). VLCD showed beneficial effect on total cholesterol level at 6 and 12 months (-0.01 mmol/L; 95%CI, -0.01 to –0.00; P = 0.002 and -0.01 mmol/L; 95%CI, -0.01 to –0.00; P = 0.005, respectively). The mean changes in weight, and fasting glucose and insulin levels revealed non-significant differences between both diets at any measured time, although these parameters decreased within both groups compared to baseline.VLCD led to significant total weighted mean decrease of diastolic BP and near significant decrease of systolic BP independent of changes in body weight, fasting glucose or insulin levels. The present data on decreased levels of diastolic BP and total cholesterol, combined with our recently published results on increased HDL-cholesterol, decreased triglycerides and no significant effect on LDL-cholesterol (1) provide evidence that VLCD are superior to LFD in improving traditional CVM in longer term.

Adipose tissue metabolism of obese mice on standard and high-fat diets

1961 ◽  
Vol 201 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Serene Lochaya ◽  
Nicole Leboeuf ◽  
Jean Mayer ◽  
Bernard Leboeuf
Keyword(s):  
Adipose Tissue ◽  
Obese Mice ◽  
High Fat ◽  
Carbon Incorporation ◽  
Adipose Tissue Metabolism ◽  
Glucose Carbon ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets ◽  
Fat Feeding

Adipose tissue metabolism in vitro was studied, after substitution for several weeks of synthetic low-carbohydrate, high-fat (saturated or unsaturated) diets for the standard chow diet, in obese hyperglycemic mice and in their nonobese littermates. In tissue from nonobese mice fed the high-fat diets, glucose metabolism to CO2 and to fatty acids was diminished in the absence of added hormone, while glucose carbon incorporation to glyceride-glycerol was increased. Under insulin (0.1 unit/ml) stimulation, total glucose uptake was relatively decreased by the diets, as was glucose metabolism to CO2, to fatty acids, and to glycogen; however, glucose carbon incorporation to glyceride-glycerol was unaltered. Under epinephrine stimulation, the sum of glucose carbon recovery was less after high-fat feeding. No effect of high-fat feeding was detected on base-line rates of free fatty acid release nor on the effects of insulin or epinephrine on this process. No differences were found between the effects of saturated- or unsaturated-fat diets on any parameters. The metabolism of adipose tissue from obese mice was slightly, if at all, affected by high-fat feeding. These results are discussed in reference to the normal adaptation to low-carbohydrate, high-fat diets and to the metabolic abnormalities present in obese hyperglycemic mice.

scholarly journals Effects of Low-Carbohydrate, High-Fat Diets on Body and Skeletal Muscle Weights in Mice

2020 ◽  
Vol 67 (4) ◽  
pp. 128-133
Author(s):  
Kanako Oshita ◽  
Yurie Hara ◽  
Nakamichi Watanabe
Keyword(s):  
Skeletal Muscle ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats

2009 ◽  
Vol 25 (2) ◽  
pp. 275-284 ◽  
Author(s):  
Maximilian Bielohuby ◽  
Maiko Matsuura ◽  
Nadja Herbach ◽  
Ellen Kienzle ◽  
Marc Slawik ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Mineral ◽  
High Fat ◽  
Mineral Density ◽  
Short Term ◽  
Short Term Exposure ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

Consumption of low-carbohydrate/high fat diets impairs glucose tolerance in rats independent of changes in body composition

2013 ◽  
Author(s):  
Maximilian Bielohuby ◽  
Ayse Zengin ◽  
Amon Horngacher ◽  
Sarina Meurer ◽  
Martin Bidlingmaier
Keyword(s):  
Body Composition ◽  
Glucose Tolerance ◽  
High Fat ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets
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