Comment on: Superior weight loss and lower HbA1c three years after duodenal switch compared to Roux-en-Y gastric bypass—a randomized controlled trial

2012 ◽  
Vol 8 (3) ◽  
pp. 343-345
Author(s):  
Mitchell S. Roslin
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Gastric Bypass ◽  
Duodenal Switch ◽  
Controlled Trial ◽  
Randomized Controlled

scholarly journals Different Limb Lengths in Gastric Bypass Surgery: Study Protocol for A Swiss Multicenter Randomized Controlled Trial (SLIM)

2020 ◽  
Author(s):  
Marko Kraljević ◽  
Romano Schneider ◽  
Bettina Wölnerhanssen ◽  
Marco Bueter ◽  
Tarik Delko ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Body Mass Index ◽  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Gastric Bypass ◽  
Body Mass ◽  
Controlled Trial ◽  
Morbidly Obese ◽  
Randomized Controlled ◽  
Multicenter Randomized Controlled Trial

Abstract Background Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions. In morbidly obese patients, bariatric operations lead to sustained weight loss and relief of comorbidities in the majority of patients. Laparoscopic Roux-Y-gastric bypass (RYGB) is one of the most frequently performed operations, but it is still unknown why some patients respond better than others. Therefore, a number of variations of this operation have been introduced. Recent evidence suggests that a longer bypassed biliopancreatic limb (BPL) has the potential to be more effective compared to the standard RYGB with a shorter BPL length. This article describes the design and protocol of a randomized controlled trial comparing the outcome of a RYGB operation with a long versus short BPL.Methods/Design The trial is designed as a multicenter, randomized, patient and observer blinded trial. The relevant ethics committee has approved the trial protocol. To demonstrate that long BPL RYGB is superior compared to short BPL RYGB in terms of weight loss and resolution of T2DM the study is conducted as a superiority trial. Postoperative percent excess body mass index loss (%EBMIL) is the primary endpoint, whereas morbidity, mortality, remission of obesity related comorbidities and quality of life are secondary endpoints. Eight hundred patients, between 18 and 65 years and with a body mass index (BMI) from 35 to 60 kg/m2 who meet the regulatory rules for bariatric surgery in Switzerland will be randomized. The endpoints and baseline measurements will be assessed pre-, intra- and postoperatively.Discussion With its high number of patients and a 5-year follow-up this study will answer questions about effectiveness and safety of long BPL RYGB and provide level I evidence for improvement of the standard RYGB. These findings might therefore potentially influence global bariatric surgery guidelines.Trial registration This trial was registered on ClinicalTrials.gov under the identifier NCT04219787, on January 7th, 2020.

scholarly journals Different limb lengths in gastric bypass surgery: study protocol for a Swiss multicenter randomized controlled trial (SLIM)

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Marko Kraljević ◽  
Romano Schneider ◽  
Bettina Wölnerhanssen ◽  
Marco Bueter ◽  
Tarik Delko ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Gastric Bypass ◽  
Gastric Bypass Surgery ◽  
Controlled Trial ◽  
Morbidly Obese ◽  
Randomized Controlled ◽  
Number Of Patients ◽  
Multicenter Randomized Controlled Trial

Abstract Background Obesity and type 2 diabetes mellitus are reaching epidemic proportions. In morbidly obese patients, bariatric operations lead to sustained weight loss and relief of comorbidities in the majority of patients. Laparoscopic Roux-Y-gastric bypass (RYGB) is one of the most frequently performed operations, but it is still unknown why some patients respond better than others. Therefore, a number of variations of this operation have been introduced. Recent evidence suggests that a longer bypassed biliopancreatic limb (BPL) has the potential to be more effective compared to the standard RYGB with a shorter BPL length. This article describes the design and protocol of a randomized controlled trial comparing the outcome of a RYGB operation with a long versus short BPL. Methods/design The trial is designed as a multicenter, randomized, patient- and observer-blinded trial. The relevant ethics committee has approved the trial protocol. To demonstrate that long BPL RYGB is superior compared to short BPL RYGB in terms of weight loss and resolution of T2DM, the study is conducted as a superiority trial. Postoperative percent total weight loss and nutritional deficiency rate are the primary endpoints, whereas morbidity, mortality, remission of obesity-related comorbidities and quality of life are secondary endpoints. Eight hundred patients, between 18 and 65 years and with a body mass index (BMI) from 35 to 60 kg/m2 who meet the regulatory rules for bariatric surgery in Switzerland, will be randomized. The endpoints and baseline measurements will be assessed pre-, intra-, and postoperatively. Discussion With its high number of patients and a 5-year follow-up, this study will answer questions about effectiveness and safety of long BPL RYGB and provide level I evidence for improvement of the standard RYGB. These findings might therefore potentially influence global bariatric surgery guidelines. Trial registration ClinicalTrials.gov NCT04219787. Registered on 7 January 2020.

Maximal weight loss after banded and unbanded laparoscopic Roux-en-Y gastric bypass: a randomized controlled trial

2008 ◽  
Vol 4 (4) ◽  
pp. 507-511 ◽  
Author(s):  
Ricardo Arceo-Olaiz ◽  
María Nayví España-Gómez ◽  
Jorge Montalvo-Hernández ◽  
David Velázquez-Fernández ◽  
Juan Pablo Pantoja ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Gastric Bypass ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Maximal Weight

Supervised Physical Training Improves Weight Loss After Roux-en-Y Gastric Bypass Surgery: A Randomized Controlled Trial

Obesity ◽  
2018 ◽  
Vol 26 (5) ◽  
pp. 828-837 ◽  
Author(s):  
Lene Hymøller Mundbjerg ◽  
Charlotte Røn Stolberg ◽  
Stefano Cecere ◽  
Else-Marie Bladbjerg ◽  
Peter Funch-Jensen ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Gastric Bypass ◽  
Physical Training ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Controlled Trial ◽  
Randomized Controlled

A randomized controlled trial of matching of deposit contracts to promote weight loss

2013 ◽  
Author(s):  
Jeffrey T. Kullgren ◽  
Andrea B. Troxel ◽  
George Loewenstein ◽  
Laurie A. Norton ◽  
Dana Gatto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Promote Weight Loss ◽  
Randomized Controlled ◽  
Deposit Contracts
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