Highly sensitive and selective electrochemical cortisol sensor using bifunctional protein interlayer-modified graphene electrodes

2017 ◽  
Vol 242 ◽  
pp. 1121-1128 ◽  
Author(s):  
Kwang Su Kim ◽  
Sung Ryeol Lim ◽  
Sung-Eun Kim ◽  
Jun Young Lee ◽  
Chan-Hwa Chung ◽  
...  
2012 ◽  
Vol 711 ◽  
pp. 246-252 ◽  
Author(s):  
Owen J. Guy ◽  
Gregory Burwell ◽  
Zari Tehrani ◽  
Ambroise Castaing ◽  
Kelly Ann Walker ◽  
...  

Biosensor diagnostics based on bio-functionalized semiconductor devices are an important development in ultrasensitive sensors for early detection of disease biomarkers. Electrochemical devices using chemically modified graphene (CMG) channels are excellent candidates for nanobiosensors. This paper presents the development of novel antibody functionalized epitaxial graphene devices for bio-sensing applications. Epitaxial graphene has been grown on silicon carbide (SiC) substrates under high vacuum and high temperature conditions (1200 – 1700°C). A generic electrochemical surface functionalisation chemistry, which can be used to attach a variety of “bio-receptors” to graphitic surfaces, has been developed. The attached bio-receptors are capable of specific and selective interaction with disease biomarkers. When a target biomarker molecule interacts with the “bio-receptor” functionalized surface, the charge density at that surface is affected. This change can be detected as an electrical signal from the biosensor, enabling highly sensitive (nM) detection of biomarker analytes. This paper reports the fabrication of graphene channel sensors for detection of disease biomarkers.


2020 ◽  
pp. 128692
Author(s):  
Francesca Bettazzi ◽  
Chiara Ingrosso ◽  
Patrick Severin Sfragano ◽  
Valentina Pifferi ◽  
Luigi Falciola ◽  
...  

2015 ◽  
Vol 7 (21) ◽  
pp. 9254-9260 ◽  
Author(s):  
Engin Er ◽  
Hüseyin Çelikkan ◽  
M. Levent Aksu ◽  
Nevin Erk

An electrochemical sensing platform based on high-quality graphene was developed to detect hydrochlorothiazide (HCT) with a highly satisfactory electrochemical activity.


2021 ◽  
Author(s):  
Zhaolin Ai ◽  
Liqian Wang ◽  
Qianying Guo ◽  
Derong Kong ◽  
Yungen Wu ◽  
...  

Direct and sensitive short-wavelength ultraviolet (UVC) dosimeters could enable safer disinfection environment against virus. We develop direct, quantitative, specific and highly sensitive UVC dosimeters based on DNA nanostructure-modified graphene field-effect...


2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Katarzyna Madej ◽  
Katarzyna Janiga ◽  
Wojciech Piekoszewski

Isolation conditions for five pesticides (metazachlor, tebuconazole, λ-cyhalothrin, chlorpyrifos, and deltamethrin) from rape oil samples were examined using the dispersive solid-phase graphene extraction technique. To determine the optimal extraction conditions, a number of experimental factors (amount of graphene, amount of salt, type and volume of the desorbing solvent, desorption time with and without sonication energy, and temperature during desorption) were studied. The compounds of interest were separated and detected by an HPLC-UV employing a Kinetex XB-C18 column and a mobile phase consisting of acetonitrile and water flowing in a gradient mode. The optimized extraction conditions were: the amount of graphene 15 mg, desorbing solvent (acetonitrile) 5 mL, time desorption 10 min at 40°C, and amount of NaCl 1 g. The detection limit for metazachlor, tebuconazole, λ-cyhalothrin, and chlorpyrifos was 62.5 ng·g−1, and for deltamethrin, it was 500 ng·g−1. The obtained results lead to the conclusion that graphene may be successfully used for the isolation of the five pesticides from rape oil. However, their determination at low concentration levels, as they occur in real oil samples, requires the employment of appropriately highly sensitive analytical methods, as well as a more suitable graphene form (e.g., magnetically modified graphene).


RSC Advances ◽  
2015 ◽  
Vol 5 (108) ◽  
pp. 88996-89002 ◽  
Author(s):  
Shabi Abbas Zaidi ◽  
Jae Ho Shin

A novel, simple fabrication of a 4-nitrophenol (4-NP) electrochemical sensor using MnO2 nanoparticles modified graphene with high sensitivity and selectivity.


2019 ◽  
Vol 146 ◽  
pp. 111751 ◽  
Author(s):  
Yang Zhou ◽  
Mingyu Ma ◽  
Hanping He ◽  
Zhiwei Cai ◽  
Nan Gao ◽  
...  

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