In situ electrocatalytic reduction of chemical warfare agent sulfur mustard by palladium modified electrode and its sensing application

2011 ◽  
Vol 160 (1) ◽  
pp. 840-849 ◽  
Author(s):  
Virendra V. Singh ◽  
Anil K. Nigam ◽  
M. Boopathi ◽  
P. Pandey ◽  
K. Ganesan ◽  
...  
Keyword(s):  
Modified Electrode ◽  
Sulfur Mustard ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Electrocatalytic Reduction ◽  
Sensing Application

Effect of doxycycline on sulfur mustard-induced respiratory lesions in guinea pigs

2005 ◽  
Vol 289 (1) ◽  
pp. L67-L74 ◽  
Author(s):  
Christophe Guignabert ◽  
Laurent Taysse ◽  
Jean-Henri Calvet ◽  
Emmanuelle Planus ◽  
Séraphin Delamanche ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Inflammatory Cell ◽  
Sulfur Mustard ◽  
Chemical Warfare Agent ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Therapeutic Tool ◽  
Gelatinase Activity ◽  
In Situ Zymography ◽  
Epithelial Lesions

Respiratory tract lesions induced by the chemical warfare agent sulfur mustard (SM) are characterized by epithelial damages associated with inflammatory cell infiltration. Here we evaluated the imbalance between gelatinase and tissue inhibitors of metalloproteinases (TIMPs), and we tested pretreatment with the protease inhibitor doxycycline. Guinea pigs were intoxicated intratracheally with SM and evaluated 24 h after exposure. Matrix metalloproteinase (MMP) gelatinase activity of bronchial lavage (BL) fluid from SM-exposed guinea pigs was high compared with controls, as shown by both zymography and biotinylated substrate degradation, whereas TIMP-1 and -2 levels by immunoblotting were similar. Extensive areas of lysis were evidenced by in situ zymography, indicating imbalance between gelatinases and inhibitors towards net proteolytic activity. Doxycycline pretreatment resulted in 1) decreased gelatinase activity (zymography, free gelatinase activity assay, and in situ zymography); 2) decreased inflammation (BL fluid cellularity and protein level); and 3) dramatic decrease in histological epithelial lesions. Our results suggest inadequate levels of TIMP to counteract increased gelatinase activity and further support a role for MMP gelatinases in SM-induced respiratory lesions. They also suggest that doxycycline may hold promise as a therapeutic tool.

scholarly journals Dynamic cytotoxic profiles of sulfur mustard in human dermal cells determined by multiparametric high-content analysis

2016 ◽  
Vol 5 (2) ◽  
pp. 583-593 ◽  
Author(s):  
Long Long ◽  
Wei Li ◽  
Wei Chen ◽  
Fei-Fei Li ◽  
Hua Li ◽  
...  
Keyword(s):  
Content Analysis ◽  
Military Personnel ◽  
Sulfur Mustard ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Major Threat ◽  
High Content Analysis ◽  
Dermal Cells

Sulfur mustard (SM) is a well known chemical warfare agent that poses a major threat to military personnel and also populace.

Carbon dot mediated trihybrid formation by reduction of GO and in situ gold nanocluster fabrication: photo-switching behaviour and degradation of chemical warfare agent stimulants

2020 ◽  
Vol 8 (44) ◽  
pp. 15735-15741
Author(s):  
Subir Paul ◽  
Niladri Hazra ◽  
Soumyajit Hazra ◽  
Arindam Banerjee
Keyword(s):  
Gold Nanoclusters ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Gold Nanocluster ◽  
Carbon Dot ◽  
Switching Behaviour ◽  
Mediated Reduction

Carbon dot mediated reduction of GO and simultaneous fabrication of gold nanoclusters leading to a trinanohybrid system, photocurrent measurements and degradation of methylparaoxon.

Selective and sensitive chromogenic and fluorogenic detection of sulfur mustard in organic, aqueous and gaseous medium

RSC Advances ◽  
2015 ◽  
Vol 5 (112) ◽  
pp. 91946-91950 ◽  
Author(s):  
Vinod Kumar ◽  
Hemlata Rana
Keyword(s):  
Gaseous Medium ◽  
Sulfur Mustard ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Sensitive Detection ◽  
Squaraine Dye

A chromogenic and fluorogenic system based on a squaraine dye (SQ) was used for the highly selective and sensitive detection of the chemical warfare agent sulfur mustard.

Graphene oxide as carboelectrocatalyst for in situ electrochemical oxidation and sensing of chemical warfare agent simulant

2013 ◽  
Vol 188 ◽  
pp. 1218-1224 ◽  
Author(s):  
Virendra V. Singh ◽  
Anil K. Nigam ◽  
Sardar S. Yadav ◽  
Brajesh K. Tripathi ◽  
Anchal Srivastava ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Electrochemical Oxidation ◽  
Chemical Warfare Agent ◽  
Chemical Warfare
Sign in / Sign up

Export Citation Format

Share Document