P369 Electrical stimulation for the treatment of obstructive sleep apnea (OSA): System design and experimental results

2006 ◽  
Vol 7 ◽  
pp. S74
Author(s):  
Gérard Auclair ◽  
Mohamad Sawan ◽  
Tommy Désilets ◽  
François Bellemare
Keyword(s):  
Obstructive Sleep Apnea ◽  
Electrical Stimulation ◽  
Sleep Apnea ◽  
System Design ◽  
Experimental Results ◽  
Obstructive Sleep

Electrical stimulation as a therapeutic approach in obstructive sleep apnea — a meta-analysis

2020 ◽  
Author(s):  
Deeban Ratneswaran ◽  
Ahmad Guni ◽  
Martino F Pengo ◽  
Miral Al-Sherif ◽  
Baiting He ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Electrical Stimulation ◽  
Sleep Apnea ◽  
Therapeutic Approach ◽  
Meta Analysis ◽  
Obstructive Sleep

scholarly journals Atrial arrhythmias and autonomic dysfunction in rats exposed to chronic intermittent hypoxia

2018 ◽  
Vol 314 (6) ◽  
pp. H1160-H1168 ◽  
Author(s):  
Sara L. Bober ◽  
John Ciriello ◽  
Douglas L. Jones
Keyword(s):  
Obstructive Sleep Apnea ◽  
Electrical Stimulation ◽  
Sleep Apnea ◽  
Intermittent Hypoxia ◽  
Receptor Protein ◽  
Chronic Intermittent Hypoxia ◽  
Programmed Electrical Stimulation ◽  
Protein Levels ◽  
Obstructive Sleep ◽  
Atrial Vulnerability

Obstructive sleep apnea, which involves chronic intermittent hypoxia (CIH), is a major risk factor for developing atrial fibrillation (AF). Whether or not CIH alone alters cardiac mechanisms to support AF is unknown. This study investigated the effects of CIH on atrial electrophysiology and arrhythmia vulnerability and evaluated the role of autonomics in CIH promotion of AF. Adult male Sprague-Dawley rats were exposed to 8 h/day of CIH or normoxia for 7 days. After exposure, rats were anesthetized for intracardiac electrophysiological experiments. Atrial effective refractory periods (AERPs) and AF inducibility were determined using programmed electrical stimulation and burst pacing in the absence and presence of autonomic receptor agonists and antagonists. Western blot analysis measured atrial protein expression of muscarinic M2, M3, and β1-adrenergic receptors. Compared with normoxia-exposed control rats, CIH-exposed rats had enhanced AF vulnerability using both programmed electrical stimulation and burst pacing, accompanied by greater AERP responses to carbachol and propranolol, lesser responses to isoproterenol, and higher atrial M2 receptor protein levels. Enhanced atrial vulnerability was accentuated by carbachol and abolished by atropine, indicating that the AF-promoting effects of CIH depended principally on parasympathetic activation. Enhancement of atrial vulnerability and AERP shortening with cholinergic agonists in CIH-exposed rats is consistent with sensitivity to parasympathetic activation. Higher responses to adrenergic receptor blockade in CIH-exposed rats is consistent with sympathetic potentiation. These findings implicate CIH as an important mediator of enhanced AF susceptibility in obstructive sleep apnea and provide novel insights into the underlying mechanisms. NEW & NOTEWORTHY Our study demonstrates, for the first time, that chronic intermittent hypoxia alone enhances vulnerability to atrial arrhythmia induction, which depends principally on parasympathetic activation. Enhanced atrial vulnerability was accompanied by heightened electrophysiological responses of the atrial myocardium to carbachol and isoproterenol, dampened responses to propranolol, and increased atrial M2 receptor protein levels.

The Effects of Transcutaneous Electrical Stimulation during Wakefulness and Sleep in Patients with Obstructive Sleep Apnea

1992 ◽  
Vol 146 (4) ◽  
pp. 1030-1036 ◽  
Author(s):  
Lee C. Edmonds ◽  
Bruce K. Daniels ◽  
Anthony W. Stanson ◽  
Patrick F. Sheedy ◽  
John W. Shepard
Keyword(s):  
Obstructive Sleep Apnea ◽  
Electrical Stimulation ◽  
Sleep Apnea ◽  
Transcutaneous Electrical Stimulation ◽  
Obstructive Sleep

Percutaneous Biphasic Electrical Stimulation for Treatment of Obstructive Sleep Apnea Syndrome

2008 ◽  
Vol 55 (1) ◽  
pp. 181-187 ◽  
Author(s):  
Lianggang Hu ◽  
Xiaomei Xu ◽  
Yongsheng Gong ◽  
Xiaofang Fan ◽  
Liangxing Wang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Electrical Stimulation ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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