P323 Predictors of insulin resistance in obstructive sleep apnea syndrome

2006 ◽  
Vol 7 ◽  
pp. S52
Author(s):  
Fotis Kapsimalis ◽  
Asimina Manousaki ◽  
George Varouchakis ◽  
Konstantinos Gourgoulianis
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sule Cilekar ◽  
Selvihan Beysel ◽  
Savas Karatas ◽  
Aydin Balci ◽  
Kursad Akaslan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Glucose Metabolism ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Visceral Adiposity ◽  
Apnea Hypopnea Index ◽  
Obstructive Sleep ◽  
Apnea Syndrome

AbstractHypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigated sTWEAK concentrations in patients OSAS and evaluated associations between sTWEAK concentrations and visceral adiposity, metabolic dysfunction, and hypoxia observed in OSAS. Forty age, sex, and body mass index-matched patients with simple habitual snoring (HSS) and 70 patients with OSAS were included. Patients were divided according to OSAS severity: mild-moderate (apnea–hypopnea index, AHI 5–30 events/h) and severe (AHI ≥ 30 events/h). Anthropometric data, glucose metabolism, visceral fat (VF) ratio, and sTWEAK levels were compared. sTWEAK levels were higher in the OSAS group than in the HSS group (931.23 ± 136.48 vs. 735.22 ± 102.84 ng/L, p = 0.001). sTWEAK levels were higher in severe OSAS than in mild-moderate OSAS (1031.83 ± 146.69 vs. 891.01 ± 110.01 ng/L, p = 0.002. When we evaluated the sTWEAK value and AHI, VF ratio, total cholesterol, blood pressure, homeostasis model of assessment-insulin resistance, and high-sensitivity C-reactive protein using multiple regression analysis, a significant correlation was found between sTWEAK levels and AHI (p < 0.001). It was found that sTWEAK levels were not correlated with glucose metabolism and VF ratio. Increased circulating sTWEAK levels were associated with the severity of OSAS. High sTWEAK levels were correlated with increased AHI. sTWEAK concentrations are linked to severe OSAS.

scholarly journals Reduced Serum Vitamin D Levels Are Associated with Insulin Resistance in Patients with Obstructive Sleep Apnea Syndrome

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 174 ◽  
Author(s):  
Kostas Archontogeorgis ◽  
Nikolaos Papanas ◽  
Evangelos C. Rizos ◽  
Evangelia Nena ◽  
Athanasios Zissimopoulos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
The Body ◽  
Model Assessment ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background and objectives: Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular and metabolic risk factors, such as insulin resistance. Furthermore, OSAS has been associated with decreased levels of vitamin D (Vit D). The aim of the study was to assess the association between Vit D levels (expressed as 25(OH)D serum levels) and insulin resistance in patients with OSAS. Materials and Methods: Serum 25(OH)D levels were measured in consecutive subjects who had undergone polysomnography and pulmonary function testing. OSAS patients were divided into those with (homeostatic model assessment [HOMA-IR] ≥ 2) and without insulin resistance (HOMA-IR < 2). Results: Overall, 92 patients (81 males) were included in the study. OSAS patients with insulin resistance significantly differed from those without insulin resistance in terms of the body-mass index (BMI) (36.3 ± 5.8 compared to 32 ± 5.6 kg/m2, respectively, p = 0.001), apnoea-hypopnoea index (AHI) (57.4 ± 28.9 compared to 40.9 ± 27.9 events/h, respectively, p = 0.009) and indices of hypoxia during sleep. Patients with OSAS and insulin resistance had lower levels of serum 25 (OH) D compared with OSAS but without insulin resistance (19.3 ± 11.5 vs 26.7 ± 12.2 ng/mL, respectively, p = 0.005). Regression analysis demonstrated a negative association of 25(OH)D levels (β = −0.048, odds ratio [OR]: 0.953, 95% confidence interval [CI]: 0.913–0.995, p = 0.030) and a positive association of BMI (β = 0.110, OR: 1.116, 95% CI: 1.007–1.237, p = 0.036) with insulin resistance. Conclusions: Vit D insufficiency was significantly more frequent among OSAS patients with insulin resistance. Both low 25(OH)D levels and high BMI were associated with the risk of insulin resistance in this population.

Obstructive sleep apnea syndrome is associated with metabolic syndrome rather than insulin resistance

2006 ◽  
Vol 11 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Altan Onat ◽  
Gülay Hergenç ◽  
Hüseyin Uyarel ◽  
Mehmet Yazıcı ◽  
Mustafa Tuncer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Insulin Resistance and Serum Leptin Levels in Men with Obstructive Sleep Apnea Syndrome

2011 ◽  
Vol 8 (4) ◽  
Author(s):  
Tacettin Örnek ◽  
Erdem Koçak ◽  
Gülay Koçak ◽  
Hatice Bakırtaş ◽  
Hulusi Atmaca ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Serum Leptin ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Insulin resistance and affecting factors in patients with obstructive sleep apnea syndrome

2017 ◽  
Vol 3 (4) ◽  
pp. 986
Author(s):  
Hatice Beyazal Polat ◽  
Metin Çeliker ◽  
Songül Özyurt ◽  
Suat Terzi ◽  
Abdülkadir Özgür
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Apnea Hypopnea Index ◽  
Obese Patients ◽  
Obstructive Sleep ◽  
The Mean ◽  
Apnea Syndrome

<p class="abstract"><strong>Background:</strong> Metabolic syndrome and insulin resistance are common in patients with obstructive sleep apnea syndrome (OSAS) independently of obesity. This study aims to examine and evaluate the insulin resistance and the factors affecting the insulin resistance in patients with OSAS.</p><p class="abstract"><strong>Methods:</strong> Patients admitted to the sleep disorders clinic of our hospital with snoring complaints and diagnosed with OSAS in the last 6 months were included to the study. Insulin resistance was calculated by the Homa-IR formula. &gt;2.7 was considered insulin resistance.  </p><p class="abstract"><strong>Results:</strong> The mean Homa-IR value was 3.86±4.69 and 42 (49.4%) patients were found to have insulin resistance. Mean insulin resistance was 2.68±2.2 in normal weight patients, 2.30±1.41 in overweight patients, 3.96±1.83 in obese patients, and 8.61±12.13 in morbid obese patients. The mean apnea hypopnea index of the patients was 22.95±15.20; 30 (35.2%) were with mild, 26 (30.6%) were with moderate and 29 (34.1%) were with severe OSAS. Insulin resistance was 2.35±1.36 in patients with mild AHI; 3.09±1.30 in<strong> </strong>patients with moderate AHI, and 6.11±7.35 in severe cases. In our study, the most significant relationship was found to be between insulin resistance in OSAS patients with insulin resistance and BMI and AHI.</p><p><strong>Conclusions:</strong> Insulin resistance is common in patients with OSAS independently of obesity. In our study, BMI and AHI were found to be the most important factors associated with insulin resistance in patients with OSAS.</p>

scholarly journals Severity Indices for Obstructive Sleep Apnea Syndrome Reflecting Glycemic Control or Insulin Resistance

2019 ◽  
Vol 58 (22) ◽  
pp. 3227-3234 ◽  
Author(s):  
Yuki Isobe ◽  
Yasuto Nakatsumi ◽  
Yu Sugiyama ◽  
Takuto Hamaoka ◽  
Hisayoshi Murai ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Glycemic Control ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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