Predictors of health-related quality of life in sufferers with restless legs syndrome: A multi-national study

2007 ◽  
Vol 8 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Louise McCrink ◽  
Richard P. Allen ◽  
Sorrel Wolowacz ◽  
Beth Sherrill ◽  
Mark Connolly ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
National Study ◽  
Health Related Quality ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related

Neurology: Effect of Non-Ergot Dopamine Agonists on Health-Related Quality of Life of Patients with Restless Legs Syndrome

2009 ◽  
Vol 43 (5) ◽  
pp. 813-821 ◽  
Author(s):  
Ripple Talati ◽  
Olivia J Phung ◽  
Jeffrey Mather ◽  
Craig I Coleman
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Dopamine Agonists ◽  
Meta Analysis ◽  
Health Related Quality ◽  
Restless Legs ◽  
Hrqol Data ◽  
Related Quality ◽  
Health Related

Background Non-ergot dopamine agonists (NEDAs) have become the gold-standard agents for the treatment of restless legs syndrome (RLS). While the efficacy and safety of these drugs have been widely studied, their effect on patients' health-related quality of life (HRQoL) has not been fully elucidated. Objective To better define the usefulness of NEDAs by assessing their impact on HRQoL. Methods We performed a meta-analysis of randomized, double-blind, placebo-controlled trials evaluating the use of NEDAs in patients with RLS. A systematic literature search of MEDLINE, EMBASE, and Cochrane CENTRAL was performed from the earliest possible date through July 2008. Trials were included in the analysis if they evaluated NEDAs for the treatment of RLS and reported HRQoL using any RLS disease-specific HRQoL instrument. HRQoL data were pooled and evaluated using an inverse variance weighting approach as standardized mean differences (SMDs) and 95% confidence interval (CI). For trials reporting HRQoL data obtained using the Johns Hopkins RLS-QoL Questionnaire, adjusted mean difference data were pooled to calculate the weighted mean difference (WMD) and 95% CI. Results Seven trials (N = 1483) met all inclusion criteria. Patients with RLS taking NEDAs had significantly improved overall effect on HRQoL compared with those taking placebo (SMD 0.20; 95% CI 0.10 to 0.30; degree of inconsistency across studies [I2] = 0%). When analyzing trials using the Johns Hopkins RLS-QoL questionnaire, the results also showed improvement with NEDAs compared with placebo (WMD 4.72; 95% CI 2.96 to 6.47; I2 = 0%). Study conclusions were unchanged upon sensitivity analysis. The number of trials for each NEDA was small, limiting the usefulness of between-agent comparisons. Conclusions In patients with RLS, use of NEDAs showed improved HRQoL compared with placebo. Since pooled effect sizes observed in this meta-analysis appear to surpass accepted values for minimally important clinical differences, these improvements may be clinically relevant for the average studied patient. However, future studies evaluating long-term treatment of RLS with NEDAs are necessary, as are head-to-head comparative trials and economic assessments.

scholarly journals 0662 Restless Legs Syndrome And Health-related Quality Of Life In Adults With Multiple Sclerosis

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A264-A264
Author(s):  
Katie L Cederberg ◽  
Brenda Jeng ◽  
Jeffer E Sasaki ◽  
Tiffany J Braley ◽  
Arthur S Walters ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Restless Legs Syndrome ◽  
Health Related Quality ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related

Burden of restless legs syndrome on health-related quality of life

2007 ◽  
Vol 16 (4) ◽  
Author(s):  
Clete Kushida ◽  
Marie Martin ◽  
Prashant Nikam ◽  
Bonnie Blaisdell ◽  
Gene Wallenstein ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Health Related Quality ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related

Health-related quality of life and restless legs syndrome among women in Sweden

2010 ◽  
Vol 64 (5) ◽  
pp. 574-579 ◽  
Author(s):  
Jan Wesström ◽  
Staffan Nilsson ◽  
Inger Sundström-Poromaa ◽  
Jan Ulfberg
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Health Related Quality ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related

scholarly journals Restless legs syndrome and health‐related quality of life in adults with multiple sclerosis

2019 ◽  
Vol 29 (3) ◽  
Author(s):  
Katie L. J. Cederberg ◽  
Brenda Jeng ◽  
Jeffer E. Sasaki ◽  
Tiffany J. Braley ◽  
Arthur S. Walters ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Restless Legs Syndrome ◽  
Health Related Quality ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related

scholarly journals PNL20 RESTLESS LEGS SYNDROME PLACES A SUBSTANTIAL BURDEN ON THE HEALTH-RELATED QUALITY OF LIFE OF US AND EUROPEAN PATIENTS

2005 ◽  
Vol 8 (3) ◽  
pp. 320
Author(s):  
MC Martin ◽  
P Nikam ◽  
B Blaisdell ◽  
CA Kushida ◽  
L Ferini Strambi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Health Related Quality ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related

scholarly journals Polysomnographic and Health-related Quality of Life Correlates of Restless Legs Syndrome in the Sleep Heart Health Study

SLEEP ◽  
2009 ◽  
Vol 32 (6) ◽  
pp. 772-778 ◽  
Author(s):  
John W. Winkelman ◽  
Susan Redline ◽  
Carol M. Baldwin ◽  
Helaine E. Resnick ◽  
Anne B. Newman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Restless Legs Syndrome ◽  
Health Study ◽  
Health Related Quality ◽  
Heart Health ◽  
Restless Legs ◽  
Related Quality ◽  
Health Related
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