Correlation between rating scales and sleep laboratory measurements in restless legs syndrome

2004 ◽  
Vol 5 (6) ◽  
pp. 561-565 ◽  
Author(s):  
D GARCIABORREGUERO ◽  
O LARROSA ◽  
Y DELALLAVE ◽  
J JOSEGRANIZO ◽  
R ALLEN
Keyword(s):  
Restless Legs Syndrome ◽  
Rating Scales ◽  
Sleep Laboratory ◽  
Laboratory Measurements ◽  
Restless Legs

Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ertan Kucuksayan ◽  
Serkan Ozben ◽  
Selma Topaloglu Tuac ◽  
Mesrure Koseoglu ◽  
Ozcan Erel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Restless Legs Syndrome ◽  
Rating Scales ◽  
Spectrophotometric Analysis ◽  
Healthy Controls ◽  
Restless Legs ◽  
Severity Rating ◽  
Total Thiol ◽  
Disease Rating ◽  
Positive Correlations

Abstract Objectives Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales. Methods A total of 25 RLS patients and 25 healthy controls were included into the study. TDH status was determined using an automated spectrophotometric analysis method and correlations were analyzed between the TDH status and various disease rating scales in the RLS patients. Results Plasma total (401 ± 27 μmol/L) and native thiol (354 ± 30 μmol/L) levels were significantly lower, but disulphide level (24 ± 6 μmol/L) was significantly (<0.0001) higher in the RLS patients compared to the controls (455 ± 36, 424 ± 37, 15 ± 5 μmol/L, respectively). The disulphide/native thiol and disulphide/total thiol ratios increased, in contrast, native thiol/total thiol ratio decreased significantly in the RLS patients compared to the healthy controls (<0.0001). The disulphide levels correlated positively with age and various rating scores of the RLS patients. International Restless Legs Syndrome Study Group (IRLSSG) rating score and age correlated negatively with the total and native thiol levels. Conclusions Our findings indicate increased oxidative stress in the RLS patients reflected by decreased native and total thiol, and increased disulphide levels and positive correlations between the disulphide levels and various rating scores. We suggest dynamic TDH status to be used as a novel biomarker for the diagnosis and follow-up of the RLS patients.

Sleep Laboratory Diagnosis of Restless Legs Syndrome

2002 ◽  
Vol 48 (2) ◽  
pp. 108-113 ◽  
Author(s):  
Martin Michaud ◽  
Jean Paquet ◽  
Gilles Lavigne ◽  
Alex Desautels ◽  
Jacques Montplaisir
Keyword(s):  
Restless Legs Syndrome ◽  
Laboratory Diagnosis ◽  
Sleep Laboratory ◽  
Restless Legs

Sleep Laboratory Studies in Restless Legs Syndrome Patients as Compared with Normals and Acute Effects of Ropinirole

2000 ◽  
Vol 41 (4) ◽  
pp. 181-189 ◽  
Author(s):  
B. Saletu ◽  
G. Gruber ◽  
M. Saletu ◽  
N. Brandstätter ◽  
C. Hauer ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Sleep Laboratory ◽  
Laboratory Studies ◽  
Acute Effects ◽  
Restless Legs

Sleep Laboratory Diagnosis of Restless Legs Syndrome

2009 ◽  
pp. 134-141
Author(s):  
Jacques Montplaisir ◽  
Martin Michaud ◽  
Marie-Hélène Pennestri ◽  
Paola Lanfranchi
Keyword(s):  
Restless Legs Syndrome ◽  
Laboratory Diagnosis ◽  
Sleep Laboratory ◽  
Restless Legs

scholarly journals Review of Severity Rating Scales for Restless Legs Syndrome: Critique and Recommendations

2014 ◽  
Vol 1 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Arthur S. Walters ◽  
Birgit Frauscher ◽  
Richard Allen ◽  
Heike Benes ◽  
K. Ray Chaudhuri ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Rating Scales ◽  
Restless Legs ◽  
Severity Rating

O0047 Sleep laboratory characteristics of patients with restless legs syndrome augmentation

2007 ◽  
Vol 8 ◽  
pp. S59-S60
Author(s):  
D. Garcia-Borreguero ◽  
R. Egatz ◽  
O. Larrosa
Keyword(s):  
Restless Legs Syndrome ◽  
Sleep Laboratory ◽  
Restless Legs

Sleep Laboratory Studies in Restless Legs Syndrome Patients as Compared with Normals and Acute Effects of Ropinirole

2000 ◽  
Vol 41 (4) ◽  
pp. 190-199 ◽  
Author(s):  
M. Saletu ◽  
P. Anderer ◽  
B. Saletu ◽  
C. Hauer ◽  
M. Mandl ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Sleep Laboratory ◽  
Laboratory Studies ◽  
Acute Effects ◽  
Restless Legs
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