How to escape the cancer attractor: Rationale and limitations of multi-target drugs

2013 ◽  
Vol 23 (4) ◽  
pp. 270-278 ◽  
Author(s):  
Sui Huang ◽  
Stuart Kauffman
Keyword(s):  
Cancer Attractor

scholarly journals A single-cell survey of cellular hierarchy in acute myeloid leukemia

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Junqing Wu ◽  
Yanyu Xiao ◽  
Jie Sun ◽  
Huiyu Sun ◽  
Haide Chen ◽  
...  
Keyword(s):  
Single Cell ◽  
Myeloid Leukemia ◽  
Drug Targets ◽  
Progenitor Cell ◽  
Potential Drug ◽  
Smrt Sequencing ◽  
Cellular Hierarchy ◽  
Potential Drug Targets ◽  
Cancer Attractor ◽  
Acute Myeloid

Abstract Background Acute myeloid leukemia (AML) is a fatal hematopoietic malignancy and has a prognosis that varies with its genetic complexity. However, there has been no appropriate integrative analysis on the hierarchy of different AML subtypes. Methods Using Microwell-seq, a high-throughput single-cell mRNA sequencing platform, we analyzed the cellular hierarchy of bone marrow samples from 40 patients and 3 healthy donors. We also used single-cell single-molecule real-time (SMRT) sequencing to investigate the clonal heterogeneity of AML cells. Results From the integrative analysis of 191727 AML cells, we established a single-cell AML landscape and identified an AML progenitor cell cluster with novel AML markers. Patients with ribosomal protein high progenitor cells had a low remission rate. We deduced two types of AML with diverse clinical outcomes. We traced mitochondrial mutations in the AML landscape by combining Microwell-seq with SMRT sequencing. We propose the existence of a phenotypic “cancer attractor” that might help to define a common phenotype for AML progenitor cells. Finally, we explored the potential drug targets by making comparisons between the AML landscape and the Human Cell Landscape. Conclusions We identified a key AML progenitor cell cluster. A high ribosomal protein gene level indicates the poor prognosis. We deduced two types of AML and explored the potential drug targets. Our results suggest the existence of a cancer attractor.

Sign in / Sign up

Export Citation Format

Share Document