CD8+ T cell immunity to Epstein-Barr virus and Kaposi’s sarcoma-associated herpes virus

2008 ◽  
Vol 18 (6) ◽  
pp. 416-422 ◽  
Author(s):  
Andrew D. Hislop ◽  
Shereen Sabbah
Keyword(s):  
T Cell ◽  
Kaposi's Sarcoma ◽  
Epstein Barr Virus ◽  
Kaposi’S Sarcoma ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Barr Virus ◽  
Cell Immunity ◽  
Epstein Barr ◽  
Herpès Virus

scholarly journals Epstein-Barr Virus Isolates Retain Their Capacity To Evade T Cell Immunity through BNLF2a despite Extensive Sequence Variation

2011 ◽  
Vol 86 (1) ◽  
pp. 572-577 ◽  
Author(s):  
D. Horst ◽  
S. R. Burrows ◽  
D. Gatherer ◽  
B. van Wilgenburg ◽  
M. J. Bell ◽  
...  
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
Sequence Variation ◽  
T Cell Immunity ◽  
Extensive Sequence ◽  
Barr Virus ◽  
Cell Immunity ◽  
Epstein Barr ◽  
Virus Isolates

scholarly journals Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes

2007 ◽  
Vol 81 (9) ◽  
pp. 4904-4908 ◽  
Author(s):  
Florian Bihl ◽  
Murli Narayan ◽  
John V. Chisholm ◽  
Leah M. Henry ◽  
Todd J. Suscovich ◽  
...  
Keyword(s):  
T Cell ◽  
Cellular Immunity ◽  
Kaposi's Sarcoma ◽  
Epstein Barr Virus ◽  
T Cell Responses ◽  
Kaposi’S Sarcoma ◽  
Barr Virus ◽  
Cell Responses ◽  
Epstein Barr ◽  
Kaposi’S Sarcoma Associated Herpesvirus

ABSTRACT The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.

A comparison of epstein-barr virus-specific T-cell immunity in malaria-endemic and -nonendemic regions of Papua New Guinea

1983 ◽  
Vol 31 (6) ◽  
pp. 727-732 ◽  
Author(s):  
D. J. Moss ◽  
S. R. Burrows ◽  
D. J. Castelino ◽  
R. G. Kane ◽  
J. H. Pope ◽  
...  
Keyword(s):  
T Cell ◽  
Papua New Guinea ◽  
Epstein Barr Virus ◽  
New Guinea ◽  
T Cell Immunity ◽  
Barr Virus ◽  
Cell Immunity ◽  
Epstein Barr

scholarly journals Epstein?Barr virus T-cell immunity despite rituximab

2007 ◽  
Vol 136 (4) ◽  
pp. 628-632 ◽  
Author(s):  
Angela K. Nehring ◽  
Ujjwal Dua ◽  
Peter Mollee ◽  
Devinder Gill ◽  
Karen Grimmett ◽  
...  
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
T Cell Immunity ◽  
Barr Virus ◽  
Cell Immunity ◽  
Epstein Barr

scholarly journals Galectin-1 mediated suppression of Epstein-Barr virus–specific T-cell immunity in classic Hodgkin lymphoma

Blood ◽  
2007 ◽  
Vol 110 (4) ◽  
pp. 1326-1329 ◽  
Author(s):  
Maher K. Gandhi ◽  
Guido Moll ◽  
Corey Smith ◽  
Ujjwal Dua ◽  
Eleanore Lambley ◽  
...  
Keyword(s):  
T Cell ◽  
Hodgkin Lymphoma ◽  
Epstein Barr Virus ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Barr Virus ◽  
Cell Responses ◽  
Cell Immunity ◽  
Epstein Barr

AbstractIn Hodgkin lymphoma (HL), the malignant Hodgkin Reed-Sternberg cells interact with the host microenvironment to create an immunosuppressive network that protects the lymphoma from immune attack. These mechanisms are not fully understood. We examined the role of the immunomodulatory protein galectin-1 (Gal-1) on Epstein-Barr virus-specific CD8+ T cell responses in HL. Initial studies indicated Gal-1 expression in all in vitro established Hodgkin Reed-Sternberg cell lines. In situ analysis revealed Gal-1 expression in 26 of 42 classic HL, whereas Gal-1 was uniformly negative in nodular lymphocyte predominant HL. Gal-1hi expression was associated with male gender, older patients, reduced CD8+ T cell infiltration at the tumor site, and most importantly, an impaired latent membrane protein 1 and 2-specific CD8+ T-cell responses. In vitro exposure to recombinant Gal-1 inhibited proliferation and interferon-γ expression by Epstein-Barr virus-specific T cells. These observations provide an important link between the Gal-1-mediated immunomodulatory networks and loss of antigen-specific T-cell function in classic HL.

Epstein-Barr virus evasion of CD8+ and CD4+ T cell immunity via concerted actions of multiple gene products

2008 ◽  
Vol 18 (6) ◽  
pp. 397-408 ◽  
Author(s):  
Maaike E. Ressing ◽  
Daniëlle Horst ◽  
Bryan D. Griffin ◽  
Judy Tellam ◽  
Jianmin Zuo ◽  
...  
Keyword(s):  
T Cell ◽  
Epstein Barr Virus ◽  
T Cell Immunity ◽  
Cd4 T Cell ◽  
Gene Products ◽  
Multiple Gene ◽  
Barr Virus ◽  
Cell Immunity ◽  
Epstein Barr
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