scholarly journals IFN-γ-induced apoptosis of human embryonic stem cell derived oligodendrocyte progenitor cells is restricted by CXCR2 signaling

2012 ◽  
Vol 9 (3) ◽  
pp. 208-217 ◽  
Author(s):  
Emanuele Tirotta ◽  
Leslie A. Kirby ◽  
Maya N. Hatch ◽  
Thomas E. Lane
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Progenitor Cells ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Ifn Γ ◽  
Induced Apoptosis

scholarly journals Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cells Express the Serotonin Receptor and Are Susceptible to JC Virus Infection

2008 ◽  
Vol 82 (17) ◽  
pp. 8896-8899 ◽  
Author(s):  
C. Schaumburg ◽  
B. A. O'Hara ◽  
T. E. Lane ◽  
W. J. Atwood
Keyword(s):  
Stem Cell ◽  
Virus Infection ◽  
Embryonic Stem Cell ◽  
Progenitor Cells ◽  
Human Embryonic Stem Cell ◽  
Jc Virus ◽  
Embryonic Stem ◽  
Specific Marker ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor

ABSTRACT We studied the susceptibility of human embryonic stem cell-derived oligodendrocyte progenitor cells to infection with JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML). A human embryonic stem cell line, H7, was used to derive an enriched population of cells expressing the oligodendrocyte progenitor cell-specific marker NG2. These cells expressed the 5HT2a receptor (5HT2aR) for JC virus and were highly susceptible to infection. Infection was reduced by treatment with anti-5HT2aR antibodies and by the 5HT2aR antagonists ritanserin and ketanserin. This is the first demonstration that human embryonic stem cell-derived oligodendrocyte progenitor cells are susceptible to JC virus infection and indicates that cells poised to replenish mature oligodendrocytes in PML lesions may also be a target of viral infection.

Immunological properties of human embryonic stem cell-derived oligodendrocyte progenitor cells

2007 ◽  
Vol 192 (1-2) ◽  
pp. 134-144 ◽  
Author(s):  
Ross M. Okamura ◽  
Jane Lebkowski ◽  
Melinda Au ◽  
Catherine A. Priest ◽  
Jerrod Denham ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Progenitor Cells ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Immunological Properties
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