Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia

2012 ◽  
Vol 137 (1-3) ◽  
pp. 124-131 ◽  
Author(s):  
Norichika Iwashiro ◽  
Motomu Suga ◽  
Yosuke Takano ◽  
Hideyuki Inoue ◽  
Tatsunobu Natsubori ◽  
...  
Keyword(s):  
High Risk ◽  
Gray Matter ◽  
Inferior Frontal Gyrus ◽  
Gray Matter Volume ◽  
First Episode ◽  
Clinical High Risk ◽  
Matter Volume ◽  
Pars Triangularis

scholarly journals Increased Gray Matter Volume of Default Model Network in Clinical-High Risk of Psychosis Individuals

2021 ◽  
Vol 168 ◽  
pp. S216-S217
Author(s):  
Gang Yao ◽  
Xiao Guo ◽  
Hui He ◽  
Dezhong Yao ◽  
Cheng Luo ◽  
...  
Keyword(s):  
High Risk ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Clinical High Risk ◽  
Model Network ◽  
Matter Volume ◽  
Default Model

Basic symptoms and gray matter volumes of patients at clinical high risk for psychosis

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Daniela Hubl ◽  
Chantal Michel ◽  
Frauke Schultze-Lutter ◽  
Martinus Hauf ◽  
Benno G. Schimmelmann ◽  
...  
Keyword(s):  
High Risk ◽  
Gray Matter ◽  
First Episode ◽  
Clinical High Risk ◽  
Significant Group ◽  
Basic Symptoms ◽  
Conversion Rates ◽  
Episode Psychosis ◽  
Ultra High Risk ◽  
Gray Matter Volumes

Abstract Background Clinical high-risk (CHR) for psychosis is indicated by ultra-high risk (UHR) and basic symptom (BS) criteria; however, conversion rates are highest when both UHR and BS criteria are fulfilled (UHR&BS). While BSs are considered the most immediate expression of neurobiological aberrations underlying the development of psychosis, research on neurobiological correlates of BS is scarce. Methods We investigated gray matter volumes (GMV) of 20 regions of interest (ROI) previously associated with UHR criteria in 90 patients from the Bern early detection service: clinical controls (CC), first-episode psychosis (FEP), UHR, BS and UHR&BS. We expected lowest GMV in FEP and UHR&BS, and highest volume in CC with UHR and BS in-between. Results Significantly, lower GMV was detected in FEP and UHR&BS patients relative to CC with no other significant between-group differences. When ROIs were analyzed separately, seven showed a significant group effect (FDR corrected), with five (inferior parietal, medial orbitofrontal, lateral occipital, middle temporal, precuneus) showing significantly lower GM volume in the FEP and/or UHR&BS groups than in the CC group (Bonferroni corrected). In the CHR group, only COGDIS scores correlated negatively with cortical volumes. Conclusions This is the first study to demonstrate that patients who fulfill both UHR and BS criteria – a population that has been associated with higher conversion rates – exhibit more severe GMV reductions relative to those who satisfy BS or UHR criteria alone. This result was mediated by the BS in the UHR&BS group, as only the severity of BS was linked to GMV reductions.

scholarly journals Differences and Similarities in Insular and Temporal Pole MRI Gray Matter Volume Abnormalities in First-Episode Schizophrenia and Affective Psychosis

2003 ◽  
Vol 60 (11) ◽  
pp. 1069 ◽  
Author(s):  
Kiyoto Kasai ◽  
Martha E. Shenton ◽  
Dean F. Salisbury ◽  
Toshiaki Onitsuka ◽  
Sarah K. Toner ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
First Episode ◽  
Affective Psychosis ◽  
Matter Volume ◽  
Temporal Pole ◽  
First Episode Schizophrenia

Relationship between body mass index and gray matter volume in first-episode schizophrenia

2015 ◽  
Vol 7 (3) ◽  
pp. 339-340
Author(s):  
Na Li ◽  
Wei Deng ◽  
Qian He ◽  
Tao Li ◽  
Hong Deng
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
First Episode ◽  
Matter Volume ◽  
First Episode Schizophrenia

Relationship between gray matter volume and clinical symtomatology in first-episode psychosis

NeuroImage ◽  
2001 ◽  
Vol 13 (6) ◽  
pp. 1084
Author(s):  
Katrine Pagsberg ◽  
William Baaré ◽  
Torben Mackeprang ◽  
Anne Marie Christensen ◽  
Tove Aarkrog ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
First Episode Psychosis ◽  
First Episode ◽  
Matter Volume ◽  
Episode Psychosis
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