Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D

2007 ◽  
Vol 89 (1-3) ◽  
pp. 147-153 ◽  
Author(s):  
Elizabeth A. Thomas ◽  
Jeffrey K. Yao
Keyword(s):  
Arachidonic Acid ◽  
Apolipoprotein D ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

Chlorobutanol, a Preservative of Desmopressin, Inhibits Human Platelet Aggregation and Release In Vitro

1990 ◽  
Vol 64 (03) ◽  
pp. 473-477 ◽  
Author(s):  
Shih-Luen Chen ◽  
Wu-Chang Yang ◽  
Tung-Po Huang ◽  
Shiang Wann ◽  
Che-ming Teng
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Atp Release ◽  
Free Calcium ◽  
Dependent Manner ◽  
Antiplatelet Effect ◽  
Human Platelet Aggregation ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

SummaryTherapeutic preparations of desmopressin for parenteral use contain the preservative chlorobutanol (5 mg/ml). We show here that chlorobutanol is a potent inhibitor of platelet aggregation and release. It exhibited a significant inhibitory activity toward several aggregation inducers in a concentration- and time-dependent manner. Thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin respectively were markedly inhibited by chlorobutanol. Chlorobutanol had no effect on elastase- treated platelets and its antiplatelet effect could be reversed. It is concluded that the antiplatelet effect of chlorobutanol is mainly due to its inhibition on the arachidonic acid pathway but it is unlikely to have a nonspecitic toxic effect. This antiplatelet effect of chlorobutanol suggests that desmopressin, when administered for improving hemostasis, should not contain chlorobutanol as a preservative.

Sex-Associated Differences On The Effect Of Asa Or Flurbiprofen On Platelet Function Ex Vivo

1981 ◽  
Author(s):  
E E Nishizawa ◽  
B A Molony ◽  
M M Meinzinger ◽  
D J Williams
Keyword(s):  
Arachidonic Acid ◽  
Platelet Function ◽  
Bleeding Time ◽  
Ex Vivo ◽  
Normal Male ◽  
Normal Response ◽  
Beneficial Effects ◽  
Acid Pathway ◽  
Induced Aggregation ◽  
Arachidonic Acid Pathway

It has been reported that although ASA may have some beneficial effects in males, no differences from placebo was detected in females in clinical trials on venous thrombosis, TIA and stroke. Since ASA inhibits platelet function and because the end-points measured in the above clinical studies may be related to platelet function, we measured bleeding time and platelet aggregation induced by collagen or arachidonic acid following oral administration of ASA (650 mg) or flurbiprofen (100 mg) in normal male and female volunteers (10 per group, total of 40 subjects) between the age of 50 and 70.No sex-associated differences in response with either drug were observed in bleeding time or platelet function. Thus, we were unable to confirm that the observation of beneficial effect of ASA in males was due to its effect on platelets. However, more interestingly there was a statistically shorter bleeding time in males (p = 0.026) before administration of drug. It was also found that despite the normal response to collagen, PRP prepared from pre-drug blood samples from 6 individuals (15%) did not aggregate when stimulated with arachidonic acid at concentrations as high as 1 mM. These results suggest that, at least in some individuals, collagen-induced aggregation may proceed by a pathway independent of the arachidonic acid pathway.

scholarly journals Hydrogen Peroxide Elicits Constriction of Skeletal Muscle Arterioles by Activating the Arachidonic Acid Pathway

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e103858 ◽  
Author(s):  
Viktória Csató ◽  
Attila Pető ◽  
Ákos Koller ◽  
István Édes ◽  
Attila Tóth ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hydrogen Peroxide ◽  
Arachidonic Acid ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway

2004 ◽  
Vol 71 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Dong-Ju Son ◽  
Mi-Ra Cho ◽  
Yong-Ri Jin ◽  
Soo-Yeon Kim ◽  
Young-Hyun Park ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Green Tea ◽  
Tea Catechins ◽  
Antiplatelet Effect ◽  
Green Tea Catechins ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

scholarly journals Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages

2014 ◽  
Vol 1838 (7) ◽  
pp. 1967-1977 ◽  
Author(s):  
Hercules Antônio da Silva-Souza ◽  
Maria Nathalia de Lira ◽  
Helio Miranda Costa-Junior ◽  
Cristiane Monteiro da Cruz ◽  
Jorge Silvio Silva Vasconcellos ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Organic Cation ◽  
Atp Release ◽  
Cation Transport ◽  
Organic Cation Transport ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease

2015 ◽  
Vol 16 (8) ◽  
pp. 825-839 ◽  
Author(s):  
Pedro Ayuso ◽  
María del Carmen Plaza-Serón ◽  
Natalia Blanca-López ◽  
Inmaculada Doña ◽  
Paloma Campo ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Respiratory Disease ◽  
Genetic Variants ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway
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