Stability indicating spectrophotometric methods for quantitative determination of carbamazepine and its degradation product, iminostilbene, in pure form and pharmaceutical formulations

2019 ◽  
Vol 214 ◽  
pp. 21-31 ◽  
Author(s):  
Ibrahim A. Naguib ◽  
Nesma Abo Elyazeed ◽  
Fadwa A. Elroby ◽  
Mohamed R. El-Ghobashy
Keyword(s):  
Quantitative Determination ◽  
Degradation Product ◽  
Pharmaceutical Formulations ◽  
Pure Form ◽  
Stability Indicating ◽  
Spectrophotometric Methods

Stability indicating spectrophotometric methods for quantitative determination of bromazepam and its degradation product

2020 ◽  
Vol 238 ◽  
pp. 118433
Author(s):  
Hany W. Darwish ◽  
Nesma A. Ali ◽  
Ibrahim A. Naguib ◽  
Mohamed R. El Ghobashy ◽  
Abdullah M. Al-Hossaini ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Degradation Product ◽  
Stability Indicating ◽  
Spectrophotometric Methods

scholarly journals Smart Stability-Indicating Spectrophotometric Methods for Determination of Binary Mixtures Without Prior Separation

2008 ◽  
Vol 91 (2) ◽  
pp. 299-310 ◽  
Author(s):  
Mohammad G El-Bardicy ◽  
Hayam M Lotfy ◽  
Mohammad A El-Sayed ◽  
Mohammad F El-Tarras
Keyword(s):  
Degradation Product ◽  
Total Content ◽  
Standard Addition ◽  
Pharmaceutical Formulations ◽  
Assay Method ◽  
Isosbestic Point ◽  
Subtraction Method ◽  
Stability Indicating ◽  
Spectrophotometric Methods

Abstract Ratio subtraction and isosbestic point methods are 2 innovating spectrophotometric methods used to determine vincamine in the presence of its acid degradation product and a mixture of cinnarizine (CN) and nicergoline (NIC). Linear correlations were obtained in the concentration range from 840 g/mL for vincamine (I), 622 g/mL for CN (II), and 636 g/mL for NIC (III), with mean accuracies 99.72 0.917 for I, 99.91 0.703 for II, and 99.58 0.847 and 99.83 1.039 for III. The ratio subtraction method was utilized for the analysis of laboratory-prepared mixtures containing different ratios of vincamine and its degradation product, and it was valid in the presence of up to 80 degradation product. CN and NIC in synthetic mixtures were analyzed by the 2 proposed methods with the total content of the mixture determined at their respective isosbestic points of 270.2 and 235.8 nm, and the content of CN was determined by the ratio subtraction method. The proposed method was validated and found to be suitable as a stability-indicating assay method for vincamine in pharmaceutical formulations. The standard addition technique was applied to validate the results and to ensure the specificity of the proposed methods.

scholarly journals Stability-Indicating Methods for Determination of Pyritinol Dihydrochloride in the Presence of Its Precursor and Degradation Product by Derivative Spectrophotometry

2005 ◽  
Vol 88 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Mostafa A Shehata ◽  
Mohammad A El-Sayed ◽  
Mohammad G El-Bardicy ◽  
Mohammad F El-Tarras
Keyword(s):  
Hydrochloric Acid ◽  
Degradation Product ◽  
Pharmaceutical Formulations ◽  
Zero Crossing ◽  
Stability Indicating ◽  
First Derivative ◽  
Linear Relationships ◽  
Assay Methods ◽  
Powdered Form

Abstract A first-derivative spectrophotometric (1D) method and a derivative-ratio zero-crossing spectrophotometric (1DD) method were used to determine pyritinol dihydrochloride (I) in the presence of its precursor (II) and its degradation product (III) with 0.1N hydrochloric acid as a solvet. Linear relationships were obtained in the ranges of 6–22 μg/mL for the (1D) method and 6–20 μg/mL for the (1DD) method. By applying the proposed methods, it was possible to determine pyritinol dihydrochloride in its pure powdered form with an accuracy of 100.36 ± 1.497% (n = 9) for the (1D) method and an accuracy of 99.92 ± 1.172% (n = 8) for the (1DD) method. Laboratory-prepared mixtures containing different ratios of (I), (II), and (III) were analyzed, and the proposed methods were valid for concentrations of ≤10% (II) and ≤50% (III). The proposed methods were validated and found to be suitable as stability-indicating assay methods for pyritinol in pharmaceutical formulations.

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