Studies of the binding mode of TXNHCH 2 COOH with calf thymus DNA by spectroscopic methods

2016 ◽  
Vol 169 ◽  
pp. 128-133 ◽  
Author(s):  
Nese Ataci ◽  
Nergis Arsu
Keyword(s):  
Binding Mode ◽  
Calf Thymus Dna ◽  
Spectroscopic Methods ◽  
Calf Thymus

Binding of an anionic fluorescent probe with calf thymus DNA and effect of salt on the probe–DNA binding: a spectroscopic and molecular docking investigation

RSC Advances ◽  
2014 ◽  
Vol 4 (108) ◽  
pp. 63549-63558 ◽  
Author(s):  
Saptarshi Ghosh ◽  
Pronab Kundu ◽  
Bijan Kumar Paul ◽  
Nitin Chattopadhyay
Keyword(s):  
Molecular Docking ◽  
Dna Binding ◽  
Fluorescent Probe ◽  
Binding Mode ◽  
Docking Studies ◽  
Calf Thymus Dna ◽  
Molecular Docking Studies ◽  
Biologically Relevant ◽  
Calf Thymus

Binding mode of biologically relevant anionic probe, ANS, with ctDNA is divulged from spectroscopic and molecular docking studies.

DNA-binding, photocleavage and anti-cancer activity of tin(IV) corrole

2018 ◽  
Vol 22 (09n10) ◽  
pp. 739-750 ◽  
Author(s):  
An-Na Xie ◽  
Zhao Zhang ◽  
Hua-Hua Wang ◽  
Atif Ali ◽  
Dong-Xu Zhang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Calf Thymus Dna ◽  
Free Base ◽  
Docking Analysis ◽  
Calf Thymus ◽  
Anti Cancer ◽  
Active Intermediate ◽  
Dna Scission ◽  
Cancer Activity

A new tin(IV) corrole, 5,10,15-tris(4-methoxycarbonylphenyl) corrole tin(IV) (1-Sn) was synthesized and characterized. The DNA binding, photocleavage and anti-cancer activity were studied and compared with its free-base. The interaction of 1-Sn and its free-base 1 with calf thymus DNA had been investigated by spectroscopic methods, viscosity measurements and molecular docking analysis. The results revealed that 1-Sn and 1 could interact with calf thymus DNA via an outside groove binding mode. Furthermore, although 1 displayed no photonuclease activity, 1-Sn exhibited good photonuclease activity as indicated by agarose gel electrophoresis, and superoxide anion might be the active intermediate for the DNA scission. Finally, 1 was nontoxic but 1-Sn displayed cytotoxicity towards A549 tumor cell lines.

scholarly journals Synthesis of New Five Coordinated Copper(II) and Nickel(II) Complexes of L-Valine and Kinetic Study of Copper(II) with Calf Thymus DNA

2002 ◽  
Vol 9 (1-2) ◽  
pp. 81-90 ◽  
Author(s):  
Aijaz Ahmad Tak ◽  
Farukh Arjmand ◽  
Sartaj Tabassum
Keyword(s):  
Metal Ion ◽  
Binding Mode ◽  
Molar Conductance ◽  
Order Conditions ◽  
Calf Thymus Dna ◽  
First Order ◽  
Reversible Redox ◽  
Calf Thymus ◽  
Vis Spectroscopy ◽  
Kinetics Of

Five coordinated novel complexes of CuII and NiII have been synthesized from benzil and 1,3- diaminopropane-CuII/NiII complex and characterized by elemental analysis, i.r., n.m.r., e.p.r, molar conductance and u.v-vis, spectroscopy. The complexes are ionic in nature and exhibit pentaeoordinated geometry around the metal ion. The reaction kinetics of C25H36N5O2CuCl with calf thymus DNA was studied by u.v-vis, spectroscopy in aqueous medium. The complex after interaction with calf thymus DNA shows shift in the absorption spectrum and hypochromicity indicating an intercalative binding mode. The Kobs values have been calculated under pseudo-first order conditions. The redox behaviour of complex C25H36N5O2CuCl in the presence and in the absence of calf thymus DNA in the aqueous solution has been investigated by cyclic voltammetry. The cyclic voitammogram exhibits one quasi-reversible redox wave corresponding to CuII/CuI redox couple with E1/2 values of -0.377 and -0.237 V respectively at a scan rate of 0.1Vs-1 .On interaction with calf thymus DNA, the complex C25H36N5O2CuCl exhibits shifts in both Ep as well as in E1/2 values, indicating strong binding of the complex to the calf thymus DNA.

New isoxazole(3,5)substituted thiosemicarbazone: Synthesis, crystal structure and spectroscopic studies of the binding mode to protein and calf thymus DNA

2017 ◽  
Vol 1150 ◽  
pp. 44-54 ◽  
Author(s):  
Lucius F.O. Bomfim Filho ◽  
Rafaela S. Barbosa ◽  
Ana E. Burgos C. ◽  
Bernardo L. Rodrigues ◽  
Letícia R. Teixeira
Keyword(s):  
Crystal Structure ◽  
Binding Mode ◽  
Spectroscopic Studies ◽  
Calf Thymus Dna ◽  
Calf Thymus

Binding mode of Co(en)3+3 with calf thymus DNA

1999 ◽  
Vol 11 (4) ◽  
pp. 193-196 ◽  
Author(s):  
Jingwan Kang ◽  
Jing Chen ◽  
Zhihua Wang ◽  
Xiaoquan Lu ◽  
Yumin Song ◽  
...  
Keyword(s):  
Binding Mode ◽  
Calf Thymus Dna ◽  
Calf Thymus

X-ray structure of 5-[2-chlorophenyl]-10-[4-methylphenyl] 1,2,5,8,9,10 hexahydro 4,6[3H,6H] acridinedione and its interaction with calf thymus DNA by spectroscopic methods

1996 ◽  
Vol 385 (2) ◽  
pp. 129-135 ◽  
Author(s):  
J. Sivaraman ◽  
K. Subramanian ◽  
D. Velmurugan ◽  
E. Subramanian ◽  
J. Seetharaman ◽  
...  
Keyword(s):  
Calf Thymus Dna ◽  
Spectroscopic Methods ◽  
X Ray ◽  
Calf Thymus
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