Infrared spectroscopic analysis of human interstitial fluid in vitro and in vivo using FT-IR spectroscopy and pulsed quantum cascade lasers (QCL): Establishing a new approach to non invasive glucose measurement

2012 ◽  
Vol 85 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Miguel Pleitez ◽  
Hermann von Lilienfeld-Toal ◽  
Werner Mäntele
Keyword(s):  
Quantum Cascade Lasers ◽  
Glucose Measurement ◽  
New Approach ◽  
Quantum Cascade ◽  
Non Invasive ◽  
Human Interstitial Fluid ◽  
Ft Ir ◽  
Cascade Lasers

scholarly journals Non-Invasive Blood Glucose Measurement Using Quantum Cascade Lasers

2018 ◽  
Vol 39 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Kiriko Yoshioka ◽  
Takuya Koyama ◽  
Saiko Kino ◽  
Yuji Matsuura
Keyword(s):  
Blood Glucose ◽  
Quantum Cascade Lasers ◽  
Blood Glucose Measurement ◽  
Glucose Measurement ◽  
Quantum Cascade ◽  
Non Invasive ◽  
Cascade Lasers

GaInAs/AlAsSb Quantum Cascade Lasers: A New Approach towards 3-to-5 μm Semiconductor Lasers

2007 ◽  
pp. 223-237
Author(s):  
Quankui Yang ◽  
Christian Manz ◽  
Wolfgang Bronner ◽  
Christian Mann ◽  
Klaus Köhler ◽  
...  
Keyword(s):  
Semiconductor Lasers ◽  
Quantum Cascade Lasers ◽  
New Approach ◽  
Quantum Cascade ◽  
Cascade Lasers

scholarly journals Infrared Spectroscopy with a Fiber-Coupled Quantum Cascade Laser for Attenuated Total Reflection Measurements Towards Biomedical Applications

Sensors ◽  
2019 ◽  
Vol 19 (23) ◽  
pp. 5130 ◽  
Author(s):  
Ine L. Jernelv ◽  
Karina Strøm ◽  
Dag Roar Hjelme ◽  
Astrid Aksnes
Keyword(s):  
Infrared Spectroscopy ◽  
Quantum Cascade Lasers ◽  
Spectral Power ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Mid Infrared ◽  
Quantum Cascade ◽  
In Vitro Investigation

The development of rapid and accurate biomedical laser spectroscopy systems in the mid-infrared has been enabled by the commercial availability of external-cavity quantum cascade lasers (EC-QCLs). EC-QCLs are a preferable alternative to benchtop instruments such as Fourier transform infrared spectrometers for sensor development as they are small and have high spectral power density. They also allow for the investigation of multiple analytes due to their broad tuneability and through the use of multivariate analysis. This article presents an in vitro investigation with two fiber-coupled measurement setups based on attenuated total reflection spectroscopy and direct transmission spectroscopy for sensing. A pulsed EC-QCL (1200–900 cm − 1 ) was used for measurements of glucose and albumin in aqueous solutions, with lactate and urea as interferents. This analyte composition was chosen as an example of a complex aqueous solution with relevance for biomedical sensors. Glucose concentrations were determined in both setup types with root-mean-square error of cross-validation (RMSECV) of less than 20 mg/dL using partial least-squares (PLS) regression. These results demonstrate accurate analyte measurements, and are promising for further development of fiber-coupled, miniaturised in vivo sensors based on mid-infrared spectroscopy.

scholarly journals Time-resolved spectral characterization of ring cavity surface emitting and ridge-type distributed feedback quantum cascade lasers by step-scan FT-IR spectroscopy

2014 ◽  
Vol 22 (3) ◽  
pp. 2656 ◽  
Author(s):  
Markus Brandstetter ◽  
Andreas Genner ◽  
Clemens Schwarzer ◽  
Elvis Mujagic ◽  
Gottfried Strasser ◽  
...  
Keyword(s):  
Quantum Cascade Lasers ◽  
Ring Cavity ◽  
Distributed Feedback ◽  
Cavity Surface ◽  
Time Resolved ◽  
Quantum Cascade ◽  
Ft Ir ◽  
Cascade Lasers ◽  
Ft Ir Spectroscopy

Coupling a Rapid-Scan FT-IR Spectrometer with Quantum Cascade Lasers within a Single Setup: An Easy Way to Reach Microsecond Time Resolution without Losing Spectral Information

2019 ◽  
Vol 91 (7) ◽  
pp. 4368-4373 ◽  
Author(s):  
Josefine Schnee ◽  
Philippe Bazin ◽  
Benoît Barviau ◽  
Frédéric Grisch ◽  
Bruno J. Beccard ◽  
...  
Keyword(s):  
Time Resolution ◽  
Quantum Cascade Lasers ◽  
Spectral Information ◽  
Quantum Cascade ◽  
Rapid Scan ◽  
Ft Ir ◽  
Cascade Lasers
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