Charge transfer complex studies between some non-steroidal anti-inflammatory drugs and π-electron acceptors

Author(s):  
Hulya Duymus ◽  
Mustafa Arslan ◽  
Mustafa Kucukislamoglu ◽  
Mustafa Zengin
2012 ◽  
Vol 10 (2) ◽  
pp. 313-319 ◽  
Author(s):  
Anca Grigoras ◽  
Virgil Barboiu

AbstractCharge transfer interactions in mixtures of poly(9-vinylcarbazole) with three nitro compounds (4,4′dinitrodibenzyl, ethyl 3,5-dinitrobenzoate and 2,2′,4,4′-tetranitrodibenzyl) were examined. GPC shows an increase of apparent polymer weight average molecular weight (MW) in mixtures compared with pure PVK. Electron acceptors show upfield 1H-NMR shifts for all mixtures. The equilibrium association constants (k) calculated from the Benesi-Hildebrand equation are 0.511, 1.371, and 1.868 L mol−1 for PVK blends with DNDB, DNBE and TNDB, respectively. Shifts of (−NO2) stretch vibrations in mixtures support charge transfer complex formation between PVK chains and electron acceptors The ability to accept electrons decreases: TNDB>DNBE>DNDB.


2015 ◽  
Vol 17 (41) ◽  
pp. 27343-27356 ◽  
Author(s):  
Jun-ichi Fujisawa ◽  
Morio Nagata ◽  
Minoru Hanaya

A novel group of organic–inorganic hybrid materials is created by the combination of titanium dioxide (TiO2) nanoparticles with bis(dicyanomethylene) (TCNX) electron acceptors.


Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.


This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)


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