scholarly journals Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy

2019 ◽  
Vol 11 ◽  
pp. 123-130 ◽  
Author(s):  
Jun-ichiro Jo ◽  
Jian-Qing Gao ◽  
Yasuhiko Tabata
Keyword(s):  
Nucleic Acid ◽  
Delivery Systems ◽  
Regenerative Therapy

Reduction-Responsive Nucleic Acid Delivery Systems To Prevent In-Stent Restenosis in Rabbits

2019 ◽  
Vol 11 (31) ◽  
pp. 28307-28316 ◽  
Author(s):  
Weijie Ye ◽  
Yiming Chen ◽  
Wenxiong Tang ◽  
Na Zhang ◽  
Zhonghao Li ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Delivery Systems ◽  
Nucleic Acid Delivery ◽  
Stent Restenosis ◽  
In Stent Restenosis

Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems

2019 ◽  
Vol 25 (12) ◽  
pp. 1066-1079 ◽  
Author(s):  
Ahad Mokhtarzadeh ◽  
Hassan Vahidnezhad ◽  
Leila Youssefian ◽  
Jafar Mosafer ◽  
Behzad Baradaran ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Delivery Systems ◽  
Spherical Nucleic Acid

scholarly journals The Impact of Alkyl‐Chain Purity on Lipid‐Based Nucleic Acid Delivery Systems – Is the Utilization of Lipid Components with Technical Grade Justified?

ChemPhysChem ◽  
2019 ◽  
Vol 20 (16) ◽  
pp. 2110-2121
Author(s):  
Dorota Pawlowska ◽  
Christopher Janich ◽  
Andreas Langner ◽  
Bodo Dobner ◽  
Christian Wölk ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Alkyl Chain ◽  
Delivery Systems ◽  
Nucleic Acid Delivery ◽  
Technical Grade ◽  
The Impact ◽  
Lipid Components

scholarly journals Oral nucleic acid therapy using multicompartmental delivery systems

2017 ◽  
Vol 10 (2) ◽  
pp. e1478 ◽  
Author(s):  
Husain Attarwala ◽  
Murui Han ◽  
Jonghan Kim ◽  
Mansoor Amiji
Keyword(s):  
Nucleic Acid ◽  
Delivery Systems ◽  
Acid Therapy

scholarly journals Peptide-Assisted Nucleic Acid Delivery Systems on the Rise

2021 ◽  
Vol 22 (16) ◽  
pp. 9092
Author(s):  
Shabnam Tarvirdipour ◽  
Michal Skowicki ◽  
Cora-Ann Schoenenberger ◽  
Cornelia G. Palivan
Keyword(s):  
Nucleic Acid ◽  
Side Effects ◽  
Nucleic Acids ◽  
Delivery Systems ◽  
Inorganic Nanoparticles ◽  
Water Soluble ◽  
Nucleic Acid Delivery ◽  
Subcellular Organelles ◽  
Cell Internalization ◽  
Site Of Action

Concerns associated with nanocarriers’ therapeutic efficacy and side effects have led to the development of strategies to advance them into targeted and responsive delivery systems. Owing to their bioactivity and biocompatibility, peptides play a key role in these strategies and, thus, have been extensively studied in nanomedicine. Peptide-based nanocarriers, in particular, have burgeoned with advances in purely peptidic structures and in combinations of peptides, both native and modified, with polymers, lipids, and inorganic nanoparticles. In this review, we summarize advances on peptides promoting gene delivery systems. The efficacy of nucleic acid therapies largely depends on cell internalization and the delivery to subcellular organelles. Hence, the review focuses on nanocarriers where peptides are pivotal in ferrying nucleic acids to their site of action, with a special emphasis on peptides that assist anionic, water-soluble nucleic acids in crossing the membrane barriers they encounter on their way to efficient function. In a second part, we address how peptides advance nanoassembly delivery tools, such that they navigate delivery barriers and release their nucleic acid cargo at specific sites in a controlled fashion.

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