Can the measurement of pulmonary diffusing capacity for nitric oxide replace the measurement of pulmonary diffusing capacity for carbon monoxide?

2017 ◽  
Vol 241 ◽  
pp. 9-16 ◽  
Author(s):  
Gerald S. Zavorsky ◽  
Ivo van der Lee
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity

Simultaneous measurement of pulmonary diffusing capacity for carbon monoxide and nitric oxide

2018 ◽  
Vol 56 (2) ◽  
pp. 100-110 ◽  
Author(s):  
Kazuhiro Yamaguchi ◽  
Takao Tsuji ◽  
Kazutetsu Aoshiba ◽  
Hiroyuki Nakamura
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Simultaneous Measurement ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity

Competitive inhibition of carbon monoxide transport: evidence against a carrier

1981 ◽  
Vol 50 (5) ◽  
pp. 1061-1064 ◽  
Author(s):  
D. Z. Rubin ◽  
D. Fujino ◽  
C. Mittman ◽  
S. M. Lewis
Keyword(s):  
Carbon Monoxide ◽  
Competitive Inhibition ◽  
Normal Adult ◽  
Gas Mixture ◽  
Diffusing Capacity ◽  
Constant Amount ◽  
Pulmonary Diffusing Capacity ◽  
Co Concentration ◽  
Carrier Molecule ◽  
Co Concentrations

The existence of a saturable carbon monoxide (CO) carrier in the lung remains controversial. The carrier hypothesis was invoked to explain data that indicated that pulmonary diffusing capacity for CO (DLCO) decreases with increasing CO concentration. To test this hypothesis, we measured DLCO in 14 normal adult subjects at three alveolar CO concentrations (60, 660, and 2,060 ppm). Each mixture contained a constant amount of labeled C18O (60 ppm) and a balance of unlabeled C16O. If a saturable carrier exists at increasing CO concentrations, the unlabeled CO would compete for most of the sites on the carrier molecule, effectively inhibiting the uptake of the labeled C18O. C18O diffusing capacities (mean +/- SD) for the three levels of CO were 34.9 +/- 5.6, 33.0 +/- 6.0, and 34.7 +/- 7.8. There were no significant differences (P greater than 0.2) among the three levels. In another group of subjects we repeated the study using a gas mixture containing 130 ppm C18O. No significant differences were found. As a result, we find no evidence to support a CO carrier hypothesis.

scholarly journals Impact of atrial septal defect closure on diffusing capacity for nitric oxide and carbon monoxide

2019 ◽  
Vol 5 (2) ◽  
pp. 00260-2018 ◽  
Author(s):  
Martina Nassif ◽  
Reindert P. van Steenwijk ◽  
Ivo van der Lee ◽  
Peter J. Sterk ◽  
Frans H.C. de Jongh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Defect Closure ◽  
Diffusing Capacity ◽  
Atrial Septal Defect Closure

scholarly journals Effect of hyperlipidaemia on pulmonary diffusing capacity for carbon monoxide.

Thorax ◽  
1979 ◽  
Vol 34 (2) ◽  
pp. 265-268 ◽  
Author(s):  
M R Partridge ◽  
J M Hughes ◽  
G R Thompson
Keyword(s):  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Pulmonary Diffusing Capacity

The value of diffusing capacity for nitric oxide and carbon monoxide in sickle cell disease

2015 ◽  
Author(s):  
Arnaud Chambellan ◽  
Stephanie Dirou ◽  
Berangere Ricolleau ◽  
Julie Graveleau ◽  
Agathe Masseau
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Diffusing Capacity ◽  
Cell Disease
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