Protective role of peroxisome proliferator-activated receptor β/δ in acute lung injury induced by prolonged hyperbaric hyperoxia in rats

2014 ◽  
Vol 199 ◽  
pp. 9-18 ◽  
Author(s):  
Xiao-Chen Bao ◽  
Yi-Qun Fang ◽  
Pu You ◽  
Shi Zhang ◽  
Jun Ma
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protective Role ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Hyperbaric Hyperoxia

Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, reduces acute lung injury in endotoxemic rats*

2005 ◽  
Vol 33 (10) ◽  
pp. 2309-2316 ◽  
Author(s):  
Dong Liu ◽  
Bang-Xiong Zeng ◽  
Shi-Hai Zhang ◽  
Yue-Lan Wang ◽  
Lian Zeng ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ?? IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY

Shock ◽  
2005 ◽  
Vol 24 (6) ◽  
pp. 547-555 ◽  
Author(s):  
Tiziana Genovese ◽  
Emanuela Mazzon ◽  
Rosanna Di Paola ◽  
Carmelo Mui?? ◽  
Concetta Crisafulli ◽  
...  
Keyword(s):  
Lung Injury ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Exogenous Ligands

scholarly journals Protective role of caffeine versus N-acetylcysteine in hyperoxic acute lung injury in neonatal rats

2017 ◽  
Vol 34 (02) ◽  
pp. 058-067
Author(s):  
A. Sadek ◽  
R. Khattab ◽  
A. Amer ◽  
A. Youssef
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Immune Reaction ◽  
Interleukin 1 ◽  
Protective Role ◽  
High Oxygen ◽  
Control Group ◽  
Albino Rats ◽  
Neonatal Rats

Abstract Introduction: Prolonged breathing of high oxygen concentration leads to hyperoxic acute lung injury. Neonatal Respiratory diseases usually require increased supplement of high oxygen concentrations, so neonates are more susceptible to hyperoxic acute lung injury. The aim of this work was to investigate the protective role of caffeine versus N-acetylcysteine against hyperoxic acute lung injury in neonatal rats. Materials and Methods: 32 albino rats aged seven days were used in this experiment. The pups were divided into four groups; 1) Control or normoxic group; rats placed in normoxic chamber where fraction of inspired oxygen (FiO2) was 0.21, 2) Hyperoxic group; rats were placed in hyperoxic chamber (FiO2>0.8) using an oxygen flow of 1.5 Litre/min, 3) Hyperoxia-CAF group; rats exposed to hyperoxia and received a single intra-peritoneal injection of 20 mg/kg caffeine just prior to exposure, and 4) Hyperoxia-NAC group; rats exposed to hyperoxia and received a single intra-peritoneal injection of 150 mg/kg N-acetylcysteine just prior to exposure. 48 hours after exposure, lung specimens were processed for histological and immunohistochemical study using caspase-3, cluster of differentiation-68-antibody (CD68) and interleukin-1-beta (IL-1β). Results: Neonatal hyperoxia led to severe impairment in lung architecture, with a highly significant increase in alveolar macrophages. Also, caspase and IL-1β immune-reaction were increased significantly as compared to control group. Caffeine could improve the histolopathological picture of hyperoxic acute lung injury, and also could decrease alveolar macrophage count and IL-1β immune-reaction better than N-acetylcysteine. Conclusion: Caffeine is more effective than N-acetylcysteine in prophylaxis against hyperoxic acute lung injury in neonates.

Respiratory Defense Mechanisms. The Protective Role of Thioredoxin/ADF in Bleomycin-induced, Acute Lung Injury.

1998 ◽  
Vol 49 (2) ◽  
pp. 109-112
Author(s):  
Shu Hashimoto ◽  
Yasuhiro Gon ◽  
Jyunji Yodoi ◽  
Takashi Horie
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Defense Mechanisms ◽  
Protective Role

Legionella-induced acute lung injury in the setting of hyperoxia: protective role of tumour necrosis factor-α

2004 ◽  
Vol 53 (8) ◽  
pp. 727-733 ◽  
Author(s):  
Chiharu Nara ◽  
Kazuhiro Tateda ◽  
Tetsuya Matsumoto ◽  
Akira Ohara ◽  
Shuichi Miyazaki ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Protective Role ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor
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