3,5,4′-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1α

2013 ◽  
Vol 185 (3) ◽  
pp. 608-614 ◽  
Author(s):  
Lijie Ma ◽  
Yilin Zhao ◽  
Beixi Li ◽  
Qingwei Wang ◽  
Xueying Liu ◽  
...  
Keyword(s):  
Lung Injury ◽  
Nuclear Factor Kappa B ◽  
Hypoxia Inducible Factor ◽  
Nuclear Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Nuclear Factor Kappa

Juglone Attenuates Sepsis-Induced Acute Lung Injury via Suppression of the TLR4/Nf-κb Pathway

2020 ◽  
Vol 18 (2) ◽  
pp. 201-206
Author(s):  
Qiu Nan ◽  
Xu Xinmei ◽  
He Yingying ◽  
Fan Chengfen
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Nuclear Factor Kappa B ◽  
Cecal Ligation ◽  
Myeloperoxidase Activity ◽  
Nuclear Factor ◽  
Cecal Ligation And Puncture ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Nuclear Factor Kappa

Sepsis, with high mortality, induces deleterious organ dysfunction and acute lung injury. Natural compounds show protective effect against sepsis-induced acute lung injury. Juglone, a natural naphthoquinone, demonstrates pharmacological actions as a pro-apoptotic substrate in tumor treatment and anti-inflammation substrate in organ injury. In this study, the influence of juglone on sepsis-induced acute lung injury was investigated. First, a septic mice model was established via cecal ligation and puncture, and then verified via histopathological analysis of lung tissues, the wet/dry mass ratio and myeloperoxidase activity was determined. Cecal ligation and puncture could induce acute lung injury in septic mice, as demonstrated by alveolar damage and increase of wet/dry mass ratio and myeloperoxidase activity. However, intragastric administration juglone attenuated cecal ligation and puncture-induced acute lung injury. Secondly, cecal ligation and puncture-induced increase of inflammatory cells in bronchoalveolar lavage fluid was also alleviated by the administration of juglone. Similarly, the protective effect of juglone against cecal ligation and puncture-induced acute lung injury was accompanied by a reduction of pro-inflammatory factor secretion in bronchoalveolar lavage fluid and lung tissues. Cecal ligation and puncture could activate toll-like receptor 4/nuclear factor-kappa B signaling pathway, and administration of juglone suppressed toll-like receptor 4/nuclear factor-kappa B activation. In conclusion, juglone attenuated cecal ligation and puncture-induced lung damage and inflammatory response through inactivation of toll-like receptor 4/nuclear factor-kappa B, suggesting a potential therapeutic strategy in the treatment of sepsis-induced acute lung injury.

Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats

Toxicology ◽  
2012 ◽  
Vol 302 (2-3) ◽  
pp. 106-113 ◽  
Author(s):  
Dalia El-Khouly ◽  
Wesam M. El-Bakly ◽  
Azza S. Awad ◽  
Hala O. El-Mesallamy ◽  
Ebtehal El-Demerdash
Keyword(s):  
Oxidative Stress ◽  
Lung Injury ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa

scholarly journals Neovascularization of stenotic aortic valve is associated with expression of nuclear factor-kappa B and hypoxia inducible factor-2 alpha

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P3911-P3911 ◽  
Author(s):  
M. Sugahara ◽  
T. Tsujino ◽  
H. Akahori ◽  
Y. Naito ◽  
H. Sawada ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Nuclear Factor Kappa B ◽  
Hypoxia Inducible Factor ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa
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