The role of nitric oxide in the neural control of breathing

2008 ◽  
Vol 164 (1-2) ◽  
pp. 143-150 ◽  
Author(s):  
Stephen R. Reeves ◽  
Narong Simakajornboon ◽  
David Gozal
Keyword(s):  
Nitric Oxide ◽  
Neural Control ◽  
Control Of Breathing ◽  
Neural Control Of Breathing

scholarly journals Computational models of the neural control of breathing

2016 ◽  
Vol 9 (2) ◽  
pp. e1371 ◽  
Author(s):  
Yaroslav I. Molkov ◽  
Jonathan E. Rubin ◽  
Ilya A. Rybak ◽  
Jeffrey C. Smith
Keyword(s):  
Neural Control ◽  
Computational Models ◽  
Control Of Breathing ◽  
Neural Control Of Breathing

scholarly journals Chronic Intermittent Hypoxia Elicits Serotonin-Dependent Plasticity in the Central Neural Control of Breathing

2001 ◽  
Vol 21 (14) ◽  
pp. 5381-5388 ◽  
Author(s):  
Liming Ling ◽  
David D. Fuller ◽  
Karen B. Bach ◽  
Richard Kinkead ◽  
E. Burdette Olson ◽  
...  
Keyword(s):  
Intermittent Hypoxia ◽  
Neural Control ◽  
Control Of Breathing ◽  
Chronic Intermittent Hypoxia ◽  
Dependent Plasticity ◽  
Neural Control Of Breathing

Neural Control of Breathing

2005 ◽  
Vol 15 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Weirong Zhang ◽  
Paul W. Davenport
Keyword(s):  
Neural Control ◽  
Control Of Breathing ◽  
Neural Control Of Breathing

The Role of Nitric Oxide in the Neural Control of Nasal Fluid Production

1997 ◽  
Vol 11 (4) ◽  
pp. 303-312 ◽  
Author(s):  
Andrew P. Lane ◽  
Jiri Prazma ◽  
Patrick J. Gibbons ◽  
Austin S. Rose ◽  
Harold C. Pillsbury
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Nasal Cavity ◽  
Neural Control ◽  
Sensory Nerve ◽  
Significant Rise ◽  
Mucin Production ◽  
Glandular Secretion ◽  
Oxide Synthase

The production of nasal fluids serves an important role in the protection of the upper respiratory system, but can also be a troublesome symptom of rhinitis. The chief sources of nasal fluids are serous and mucous glandular secretion, epithelial goblet cell exocytosis, and exudation from submucosal blood vessels. This study was designed to investigate the role of nitric oxide in neurogenically mediated nasal vascular exudation and mucus secretion. A rat model of the naso-nasal reflex was developed in which one nasal cavity was challenged with histamine while albumin and mucin production were measured in the continuously perfused contralateral side. Histamine challenge was associated with a significant rise in contralateral albumin and mucin content. Perfusion with a nitric oxide synthase inhibitor (L-NAME) in the nasal cavity contralateral to nasal challenge was found to block albumin leakage, but not mucin secretion, on that side. The inhibition of vascular exudation was overcome by the addition of L-arginine, the natural substrate of nitric oxide synthase, to the perfusate. Treatment of the ipsilateral nasal cavity with L-NAME did not significantly alter the contralateral response. A high correlation was observed between albumin and mucin concentration in the perfusate. These findings indicate that NO is a mediator of the effector arm of the naso-nasal reflex that increases vascular permeability, but is not involved in the sensory nerve afferent pathway or in reflex mucin release. Further elucidation of the role of NO in nasal physiology may lead to novel pharmacotherapeutic approaches to the treatment of allergic and nonallergic rhinitis.

Respiratory Central Pattern Generator: Microcircuit Generation of the Rhythms and Patterns of Breathing

2017 ◽  
pp. 475-488
Author(s):  
Kaiwen Kam ◽  
Jack L. Feldman
Keyword(s):  
Central Pattern Generator ◽  
Neurodegenerative Disorders ◽  
Neural Control ◽  
Motor Behavior ◽  
Pattern Generator ◽  
Control Of Breathing ◽  
Facial Nucleus ◽  
Metabolic Demand ◽  
Previous Edition ◽  
Neural Control Of Breathing

Breathing is a vital rhythmic motor behavior that mediates gas exchange to support metabolism and regulate pH. All mammals must breathe continuously and reliably from birth and modulate their breathing throughout life in response to changes in metabolic demand and environmental stimuli. A number of congenital and neurodegenerative disorders affect the neural control of breathing in humans and lead to serious adverse health consequences, even death. Since the previous edition of this book, there have been considerable advances in our understanding of the breathing central pattern generator (CPG). This chapter focuses on the neural microcircuit within the preBötzinger Complex (preBötC); a second oscillator near the facial nucleus that appears to generate active expiration; and the microcircuit for sighing.

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