Effects of a 4-week training with voluntary hypoventilation carried out at low pulmonary volumes

2008 ◽  
Vol 160 (2) ◽  
pp. 123-130 ◽  
Author(s):  
Xavier Woorons ◽  
Pascal Mollard ◽  
Aurélien Pichon ◽  
Alain Duvallet ◽  
Jean-Paul Richalet ◽  
...  
2014 ◽  
Vol 18 (suppl 1) ◽  
pp. S48-S48
Author(s):  
M. Rodriguez ◽  
M. T. Gomez-Hernandez ◽  
N. Novoa ◽  
J. L. Aranda ◽  
M. F. Jimenez ◽  
...  

2019 ◽  
Vol 45 (3) ◽  
Author(s):  
Thamine Lessa ◽  
Carlos Alberto de Castro Pereira ◽  
Maria Raquel Soares ◽  
Renato Matos ◽  
Virgínia Pacheco Guimarães ◽  
...  

ABSTRACT Objective: To derive reference values for healthy white Brazilian adults who have never smoked and to compare the obtained values with reference values derived by Crapo and by Neder. Methods: Reference equations by quantile regressions were derived in 122 men and 122 women, non-obese, living in seven cities in Brazil. Age ranged from 21 to 92 years in women and from 25 to 88 years in men. Lung function tests were performed using SensorMedics automated body plethysmographies according ATS/ERS recommendations. Lower and upper limits were derived by specific equations for 5 and 95 percentiles. The results were compared to those suggested by Crapo in 1982, and Neder in 1999. Results: Median values for total lung capacity (TLC) were influenced only by stature in men, and by stature and age in women. Residual volume was influenced by age and stature in both genders. Weight was directly related to inspiratory capacity and inversely with functional residual capacity and expiratory reserve volume in both genders. A comparison of observed TLC data with values predicted by Neder equations showed significant lower values by the present data. Mean values were similar between data from present study and those derived by Crapo. Conclusion: New predicted values for lung volumes were obtained in a sample of white Brazilians. The values differ from those derived by Neder, but are similar to those derived by Crapo.


1999 ◽  
Vol 96 (5) ◽  
pp. 499-506 ◽  
Author(s):  
Giorgio SCANO ◽  
Giuseppe SEGHIERI ◽  
Marco MANCINI ◽  
Mario FILIPPELLI ◽  
Roberto DURANTI ◽  
...  

Dyspnoea and pulmonary dysfunction have recently been associated with Type I (insulin-dependent) diabetes mellitus. The putative role of altered pulmonary mechanics and of performance of inspiratory muscles in inducing dyspnoea has not been yet assessed in Type I diabetes. To better focus on this topic we evaluated nine patients with Type I diabetes mellitus, aged 19 to 48 years with good and stable metabolic control, without a history of smoking and microvascular complications, alongside a group of 14 healthy control subjects. In each subject, pulmonary volumes, static and dynamic compliance, pleural pressure swings (Pplsw), maximal inspiratory pressures (Pplsn), Pplsw(%Pplsn), a measure of respiratory muscle effort, and tension–time index [TTI = TI/TTOT×Pplsw(%Pplsn)] were measured (TI = inspiratory time;TTOT = total time of the respiratory cycle). All subjects were studied at baseline and during hypoxic rebreathing. Patients had normal pulmonary volumes. During hypoxic rebreathing, a normal change in respiratory muscle effort [ΔPplsw(%Pplsn)/ΔSaO2] and ΔTTI/ΔSaO2, and a lower change in tidal volume versus change in oxygen saturation [ΔVT(% vital capacity)/ΔSaO2], resulted in a higher ratio of respiratory effort to tidal volume [Pplsw(%Pplsn)/VT(% vital capacity)], a measure of neuroventilatory dissociation of the respiratory pump. Hypoxic dyspnoea, assessed by a modified Borg scale, showed a greater rate of rise (ΔBorg/ΔSaO2) and a greater increase for a given level of respiratory effort in patients. Moreover, neuroventilatory dissociation related to the expression of peripheral airway involvement, as assessed in terms of low dynamic compliance, and to concurrent change in dyspnoea sensation. Patients with Type I diabetes mellitus under good metabolic control and with normal lung volumes may have abnormal peripheral airway function. The latter is thought to be responsible for the association between dyspnoea sensation and neuroventilatory dissociation.


1985 ◽  
Vol 59 (6) ◽  
pp. 1698-1703 ◽  
Author(s):  
J. R. Catterall ◽  
P. M. Calverley ◽  
W. MacNee ◽  
P. M. Warren ◽  
C. M. Shapiro ◽  
...  

In five patients with hypoxic chronic bronchitis and emphysema we measured ear O2 saturation (SaO2), chest movement, oronasal airflow, arterial and mixed venous gas tensions, and cardiac output during nine hypoxemic episodes (HE; SaO2 falls greater than 10%) in rapid-eye-movement (REM) sleep and during preceding periods of stable oxygenation in non-REM sleep. All nine HE occurred with recurrent short episodes of reduced chest movement, none with sleep apnea. The arterial PO2 (PaO2) fell by 6.0 +/- 1.9 (SD) Torr during the HE (P less than 0.01), but mean arterial PCO2 (PaCO2) rose by only 1.4 +/- 2.4 Torr (P greater than 0.4). The arteriovenous O2 content difference fell by 0.64 +/- 0.43 ml/100 ml of blood during the HE (P less than 0.05), but there was no significant change in cardiac output. Changes observed in PaO2 and PaCO2 during HE were similar to those in four normal subjects during 90 s of voluntary hypoventilation, when PaO2 fell by 12.3 +/- 5.6 Torr (P less than 0.05), but mean PaCO2 rose by only 2.8 +/- 2.1 Torr (P greater than 0.4). We suggest that the transient hypoxemia which occurs during REM sleep in patients with chronic bronchitis and emphysema could be explained by hypoventilation during REM sleep but that the importance of changes in distribution of ventilation-perfusion ratios cannot be assessed by presently available techniques.


2017 ◽  
Vol 43 (6) ◽  
pp. 409-415 ◽  
Author(s):  
Danize Aparecida Rizzetti ◽  
Janayna Rodembuch Borba Quadros ◽  
Bruna Esmerio Ribeiro ◽  
Letícia Callegaro ◽  
Aline Arebalo Veppo ◽  
...  

ABSTRACT Objective: To determine whether different levels of CPAP improve the lung volumes and capacities of healthy subjects immersed in water. Methods: This was a randomized clinical trial, conducted between April and June of 2016, involving healthy female volunteers who were using oral contraceptives. Three 20-min immersion protocols were applied: control (no CPAP); CPAP5 (CPAP at 5 cmH2O); and CPAP10 (CPAP at 10 cmH2O). We evaluated HR, SpO2, FVC, FEV1, the FEV1/FVC ratio, peak expiratory flow rate (PEFR), and FEF25-75%) at three time points: pre-immersion; 10 min after immersion; and 10 min after the end of each protocol. Results: We evaluated 13 healthy volunteers. The CPAP10 protocol reversed the restrictive pattern of lung function induced by immersion in water, maintaining pulmonary volumes and capacities for a longer period than did the CPAP5 protocol. Conclusions: When the hemodynamic change causing a persistent lung disorder, only the application of higher positive pressures is effective in maintaining long-term improvements in the pulmonary profile.


2017 ◽  
Vol 12 (3) ◽  
pp. 329-335 ◽  
Author(s):  
Laurent Trincat ◽  
Xavier Woorons ◽  
Grégoire P. Millet

Purpose:Repeated-sprint training in hypoxia (RSH) has been shown as an efficient method for improving repeated-sprint ability (RSA) in team-sport players but has not been investigated in swimming. We assessed whether RSH with arterial desaturation induced by voluntary hypoventilation at low lung volume (VHL) could improve RSA to a greater extent than the same training performed under normal breathing (NB) conditions.Methods:Sixteen competitive swimmers completed 6 sessions of repeated sprints (2 sets of 16 × 15 m with 30 s send-off) either with VHL (RSH-VHL, n = 8) or with NB (RSN, n = 8). Before and after training, performance was evaluated through an RSA test (25-m all-out sprints with 35 s send-off) until exhaustion.Results:From before to after training, the number of sprints was significantly increased in RSH-VHL (7.1 ± 2.1 vs 9.6 ± 2.5; P < .01) but not in RSN (8.0 ± 3.1 vs 8.7 ± 3.7; P = .38). Maximal blood lactate concentration ([La]max) was higher after than before in RSH-VHL (11.5 ± 3.9 vs 7.9 ± 3.7 mmol/L; P = .04) but was unchanged in RSN (10.2 ± 2.0 vs 9.0 ± 3.5 mmol/L; P = .34). There was a strong correlation between the increases in the number of sprints and in [La]max in RSH-VHL only (R = .93, P < .01).Conclusions:RSH-VHL improved RSA in swimming, probably through enhanced anaerobic glycolysis. This innovative method allows inducing benefits normally associated with hypoxia during swim training in normoxia.


1989 ◽  
Vol 67 (5) ◽  
pp. 2055-2059 ◽  
Author(s):  
A. M. Lorino ◽  
M. Meignan ◽  
P. Bouissou ◽  
G. Atlan

The effects of intensive prolonged exercise on the pulmonary clearance rate of aerosolized 99mTc-labeled diethylenetriaminepentaacetate (99mTc-DTPA) and pulmonary mechanics were studied in seven healthy nonsmoking volunteers. 99mTc-DTPA clearance and pulmonary mechanics (lung volumes and compliance) were assessed before and after 75 min of constant-load exercise performed on a treadmill, corresponding to 75% of maximal O2 uptake. Because both clearance measurements were made in similar conditions of pulmonary blood flow, respiratory rate, and tidal volume, changes in clearance rate can be assumed to represent changes of alveolar epithelial permeability. After exercise, total, apical, and basal clearance were significantly increased (P less than 0.01, 0.05, and 0.05, respectively) and the increases in total clearance and tidal volume observed during exercise were significantly correlated (P less than 0.05). In contrast, no significant change was found in pulmonary mechanics. These results show that prolonged intensive exercise induces an increase in epithelial permeability, which appears to be related to the mechanical effects of sustained increased ventilation. Because no change was evidenced in pulmonary volumes or in lung elasticity, our results suggest that this increase may result from alteration of the intercellular tight junctions rather than from a surfactant deficiency.


2012 ◽  
Vol 148 (4) ◽  
pp. 534-542 ◽  
Author(s):  
Melisa Kiyamu ◽  
Abigail Bigham ◽  
Esteban Parra ◽  
Fabiola León-Velarde ◽  
María Rivera-Chira ◽  
...  

2015 ◽  
Vol 42 (5) ◽  
pp. 657-660 ◽  
Author(s):  
A. Ala ◽  
S. Shams-Vahdati ◽  
A. Taghizadieh ◽  
S. H. Miri ◽  
N. Kazemi ◽  
...  

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